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Article: Maturation of otolith-related brainstem neurons in the detection of vertical linear acceleration in rats

TitleMaturation of otolith-related brainstem neurons in the detection of vertical linear acceleration in rats
Authors
Keywordsc-fos
Gravity
Postnatal
Vestibular nuclei
Issue Date2006
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN
Citation
European Journal Of Neuroscience, 2006, v. 23 n. 9, p. 2431-2446 How to Cite?
AbstractTo investigate the critical maturation time of otolith-related neurons in processing vertical orientations, rats (postnatal day 4 to adults) were studied for functional activation of c-fos expression in brainstem neurons by immuno-/hybridization histochemistry. Conscious rats were subjected to sinusoidal linear acceleration along the vertical plane. Labyrinthectomized and/or stationary controls showed only sporadically scattered Fos-labeled neurons in the vestibular nuclei, confirming an otolithic origin of c-fos expression. Functionally activated Fos expression in neurons of the medial and spinal vestibular nuclei and group x were identifiable by P7 and those in group y by P9. A small number of Fos-labeled neurons characterized by small soma size were found in the ventral part of lateral vestibular nucleus by P9. Other vestibular-related areas such as prepostitus hypoglossal nucleus, gigantocellular reticular nucleus and locus coeruleus of normal experimental rats showed functionally activated c-fos expression at P7. Neurons in dorsal medial cell column and beta subnucleus of the inferior olive only showed functionally activated c-fos expression by the second postnatal week. These findings revealed a unique critical maturation time for each of the vestibular-related brainstem areas in the recognition of gravity-related vertical head orientations. By mapping the three-dimensional distribution of Fos-immunoreactive neurons, we found an even distribution of otolith-related neurons within the spinal vestibular nucleus in groups x and y but a clustered distribution in the middle-lateral-ventral part of the medial vestibular nucleus. Taken together, our findings reveal the developmental profile of neuronal subpopulations within the vertical otolith system, thereby providing an anatomical basis for postnatal coding of gravity-related vertical head movements. © The Authors (2006).
Persistent Identifierhttp://hdl.handle.net/10722/68086
ISSN
2015 Impact Factor: 2.975
2015 SCImago Journal Rankings: 2.130
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, SKen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorYung, KKLen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-06T06:01:12Z-
dc.date.available2010-09-06T06:01:12Z-
dc.date.issued2006en_HK
dc.identifier.citationEuropean Journal Of Neuroscience, 2006, v. 23 n. 9, p. 2431-2446en_HK
dc.identifier.issn0953-816Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68086-
dc.description.abstractTo investigate the critical maturation time of otolith-related neurons in processing vertical orientations, rats (postnatal day 4 to adults) were studied for functional activation of c-fos expression in brainstem neurons by immuno-/hybridization histochemistry. Conscious rats were subjected to sinusoidal linear acceleration along the vertical plane. Labyrinthectomized and/or stationary controls showed only sporadically scattered Fos-labeled neurons in the vestibular nuclei, confirming an otolithic origin of c-fos expression. Functionally activated Fos expression in neurons of the medial and spinal vestibular nuclei and group x were identifiable by P7 and those in group y by P9. A small number of Fos-labeled neurons characterized by small soma size were found in the ventral part of lateral vestibular nucleus by P9. Other vestibular-related areas such as prepostitus hypoglossal nucleus, gigantocellular reticular nucleus and locus coeruleus of normal experimental rats showed functionally activated c-fos expression at P7. Neurons in dorsal medial cell column and beta subnucleus of the inferior olive only showed functionally activated c-fos expression by the second postnatal week. These findings revealed a unique critical maturation time for each of the vestibular-related brainstem areas in the recognition of gravity-related vertical head orientations. By mapping the three-dimensional distribution of Fos-immunoreactive neurons, we found an even distribution of otolith-related neurons within the spinal vestibular nucleus in groups x and y but a clustered distribution in the middle-lateral-ventral part of the medial vestibular nucleus. Taken together, our findings reveal the developmental profile of neuronal subpopulations within the vertical otolith system, thereby providing an anatomical basis for postnatal coding of gravity-related vertical head movements. © The Authors (2006).en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJNen_HK
dc.relation.ispartofEuropean Journal of Neuroscienceen_HK
dc.rightsEuropean Journal of Neuroscience. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectc-fosen_HK
dc.subjectGravityen_HK
dc.subjectPostnatalen_HK
dc.subjectVestibular nucleien_HK
dc.subject.meshAccelerationen_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBehavior, Animalen_HK
dc.subject.meshBrain Mappingen_HK
dc.subject.meshBrain Stem - cytology - growth & developmenten_HK
dc.subject.meshCell Count - methodsen_HK
dc.subject.meshEar, Inner - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Developmentalen_HK
dc.subject.meshImmunohistochemistry - methodsen_HK
dc.subject.meshIn Situ Hybridization - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNeurons - physiologyen_HK
dc.subject.meshOncogene Proteins v-fos - metabolismen_HK
dc.subject.meshOtolithic Membrane - innervation - physiologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshRotationen_HK
dc.subject.meshTime Factorsen_HK
dc.titleMaturation of otolith-related brainstem neurons in the detection of vertical linear acceleration in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0953-816X&volume=23&issue=9&spage=2431&epage=46 &date=2006&atitle=Maturation+of+otolith-related+brainstem+neurons+in+the+detection+of+vertical+linear+acceleration+in+ratsen_HK
dc.identifier.emailLai, CH: chlaib@hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1460-9568.2006.04762.xen_HK
dc.identifier.pmid16706850-
dc.identifier.scopuseid_2-s2.0-33646698169en_HK
dc.identifier.hkuros121179en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646698169&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2431en_HK
dc.identifier.epage2446en_HK
dc.identifier.isiWOS:000237603500018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLai, SK=7402937165en_HK
dc.identifier.scopusauthoridLai, CH=7403086597en_HK
dc.identifier.scopusauthoridYung, KKL=13605496000en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.citeulike637938-

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