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Conference Paper: Genetics of disc degeneration

TitleGenetics of disc degeneration
Authors
KeywordsDegenerative disc disease
Genes
Genetics
Genomics
Intervertebral disc degeneration
Mutations
Issue Date2006
PublisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586
Citation
European Spine Journal, 2006, v. 15 SUPPL. 3, p. S317-S325 How to Cite?
AbstractLow back pain from degenerative disc disease (DDD) is one of the most common disorders seen in general and orthopaedic practices. DDD has been attributed to the accumulation of environmental factors, primarily mechanical insults and injuries, imposed on the "normal" aging changes. However, recent studies have shown an association between genetic influences and disc degeneration, with risk of developing DDD quoted to be increased up to six times that of the general population. It is likely that DDD is a complex, multifactorial disease determined by the interplay between gene(s) and the environment. This review focuses on the evidence for genetic disposition, the genes or biological processes that are implicated, and the need to consolidate resources and clarify phenotype definition to take advantage of the new technologies in genetic analysis to enhance our understanding of this condition. © Springer-Verlag 2006.
Persistent Identifierhttp://hdl.handle.net/10722/68073
ISSN
2015 Impact Factor: 2.132
2015 SCImago Journal Rankings: 0.972
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, Den_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorCheung, KMCen_HK
dc.date.accessioned2010-09-06T06:01:05Z-
dc.date.available2010-09-06T06:01:05Z-
dc.date.issued2006en_HK
dc.identifier.citationEuropean Spine Journal, 2006, v. 15 SUPPL. 3, p. S317-S325en_HK
dc.identifier.issn0940-6719en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68073-
dc.description.abstractLow back pain from degenerative disc disease (DDD) is one of the most common disorders seen in general and orthopaedic practices. DDD has been attributed to the accumulation of environmental factors, primarily mechanical insults and injuries, imposed on the "normal" aging changes. However, recent studies have shown an association between genetic influences and disc degeneration, with risk of developing DDD quoted to be increased up to six times that of the general population. It is likely that DDD is a complex, multifactorial disease determined by the interplay between gene(s) and the environment. This review focuses on the evidence for genetic disposition, the genes or biological processes that are implicated, and the need to consolidate resources and clarify phenotype definition to take advantage of the new technologies in genetic analysis to enhance our understanding of this condition. © Springer-Verlag 2006.en_HK
dc.languageengen_HK
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586en_HK
dc.relation.ispartofEuropean Spine Journalen_HK
dc.subjectDegenerative disc diseaseen_HK
dc.subjectGenesen_HK
dc.subjectGeneticsen_HK
dc.subjectGenomicsen_HK
dc.subjectIntervertebral disc degenerationen_HK
dc.subjectMutationsen_HK
dc.subject.meshExtracellular Matrix Proteins - genetics-
dc.subject.meshGenetic Linkage - genetics-
dc.subject.meshGenetic Predisposition to Disease - genetics-
dc.subject.meshIntervertebral Disk - metabolism - pathology - physiopathology-
dc.subject.meshIntervertebral Disk Displacement - genetics - metabolism - physiopathology-
dc.titleGenetics of disc degenerationen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0940-6719&volume=15 Suppl 3&spage=S317&epage=S325&date=2006&atitle=Genetics+of+disc+degenerationen_HK
dc.identifier.emailChan, D: chand@hku.hken_HK
dc.identifier.emailSong, Y: songy@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authoritySong, Y=rp00488en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1007/s00586-006-0171-3en_HK
dc.identifier.pmid16819621-
dc.identifier.pmcidPMC2335375-
dc.identifier.scopuseid_2-s2.0-33748564011en_HK
dc.identifier.hkuros123820en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748564011&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issueSUPPL. 3en_HK
dc.identifier.spageS317en_HK
dc.identifier.epageS325en_HK
dc.identifier.isiWOS:000241321100004-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridSong, Y=7404921212en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK

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