File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1007/s00586-006-0171-3
- Scopus: eid_2-s2.0-33748564011
- PMID: 16819621
- WOS: WOS:000241321100004
- Find via
Supplementary
- Citations:
- Appears in Collections:
Conference Paper: Genetics of disc degeneration
Title | Genetics of disc degeneration |
---|---|
Authors | |
Keywords | Degenerative disc disease Genes Genetics Genomics Intervertebral disc degeneration Mutations |
Issue Date | 2006 |
Publisher | Springer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586 |
Citation | European Spine Journal, 2006, v. 15 suppl. 3, p. S317-S325 How to Cite? |
Abstract | Low back pain from degenerative disc disease (DDD) is one of the most common disorders seen in general and orthopaedic practices. DDD has been attributed to the accumulation of environmental factors, primarily mechanical insults and injuries, imposed on the "normal" aging changes. However, recent studies have shown an association between genetic influences and disc degeneration, with risk of developing DDD quoted to be increased up to six times that of the general population. It is likely that DDD is a complex, multifactorial disease determined by the interplay between gene(s) and the environment. This review focuses on the evidence for genetic disposition, the genes or biological processes that are implicated, and the need to consolidate resources and clarify phenotype definition to take advantage of the new technologies in genetic analysis to enhance our understanding of this condition. © Springer-Verlag 2006. |
Persistent Identifier | http://hdl.handle.net/10722/68073 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 1.042 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, D | en_HK |
dc.contributor.author | Song, Y | en_HK |
dc.contributor.author | Sham, P | en_HK |
dc.contributor.author | Cheung, KMC | en_HK |
dc.date.accessioned | 2010-09-06T06:01:05Z | - |
dc.date.available | 2010-09-06T06:01:05Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | European Spine Journal, 2006, v. 15 suppl. 3, p. S317-S325 | en_HK |
dc.identifier.issn | 0940-6719 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/68073 | - |
dc.description.abstract | Low back pain from degenerative disc disease (DDD) is one of the most common disorders seen in general and orthopaedic practices. DDD has been attributed to the accumulation of environmental factors, primarily mechanical insults and injuries, imposed on the "normal" aging changes. However, recent studies have shown an association between genetic influences and disc degeneration, with risk of developing DDD quoted to be increased up to six times that of the general population. It is likely that DDD is a complex, multifactorial disease determined by the interplay between gene(s) and the environment. This review focuses on the evidence for genetic disposition, the genes or biological processes that are implicated, and the need to consolidate resources and clarify phenotype definition to take advantage of the new technologies in genetic analysis to enhance our understanding of this condition. © Springer-Verlag 2006. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Springer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586 | en_HK |
dc.relation.ispartof | European Spine Journal | en_HK |
dc.subject | Degenerative disc disease | en_HK |
dc.subject | Genes | en_HK |
dc.subject | Genetics | en_HK |
dc.subject | Genomics | en_HK |
dc.subject | Intervertebral disc degeneration | en_HK |
dc.subject | Mutations | en_HK |
dc.subject.mesh | Extracellular Matrix Proteins - genetics | - |
dc.subject.mesh | Genetic Linkage - genetics | - |
dc.subject.mesh | Genetic Predisposition to Disease - genetics | - |
dc.subject.mesh | Intervertebral Disk - metabolism - pathology - physiopathology | - |
dc.subject.mesh | Intervertebral Disk Displacement - genetics - metabolism - physiopathology | - |
dc.title | Genetics of disc degeneration | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0940-6719&volume=15 Suppl 3&spage=S317&epage=S325&date=2006&atitle=Genetics+of+disc+degeneration | en_HK |
dc.identifier.email | Chan, D: chand@hku.hk | en_HK |
dc.identifier.email | Song, Y: songy@hku.hk | en_HK |
dc.identifier.email | Sham, P: pcsham@hku.hk | en_HK |
dc.identifier.email | Cheung, KMC: cheungmc@hku.hk | en_HK |
dc.identifier.authority | Chan, D=rp00540 | en_HK |
dc.identifier.authority | Song, Y=rp00488 | en_HK |
dc.identifier.authority | Sham, P=rp00459 | en_HK |
dc.identifier.authority | Cheung, KMC=rp00387 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1007/s00586-006-0171-3 | en_HK |
dc.identifier.pmid | 16819621 | - |
dc.identifier.pmcid | PMC2335375 | - |
dc.identifier.scopus | eid_2-s2.0-33748564011 | en_HK |
dc.identifier.hkuros | 123820 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33748564011&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 15 | en_HK |
dc.identifier.issue | suppl. 3 | en_HK |
dc.identifier.spage | S317 | en_HK |
dc.identifier.epage | S325 | en_HK |
dc.identifier.isi | WOS:000241321100004 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Chan, D=7402216545 | en_HK |
dc.identifier.scopusauthorid | Song, Y=7404921212 | en_HK |
dc.identifier.scopusauthorid | Sham, P=34573429300 | en_HK |
dc.identifier.scopusauthorid | Cheung, KMC=7402406754 | en_HK |
dc.customcontrol.immutable | sml 170615 amended | - |
dc.identifier.issnl | 0940-6719 | - |