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Article: Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells

TitleProkineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells
Authors
KeywordsGDNF
Neural crest cell
Prok-1
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbamcr
Citation
Biochimica Et Biophysica Acta - Molecular Cell Research, 2008, v. 1783 n. 3, p. 467-478 How to Cite?
AbstractEnteric neural crest cells (NCC) are multipotent progenitors which give rise to neurons and glia of the enteric nervous system (ENS) during fetal development. Glial cell line-derived neurotrophic factor (GDNF)/RET receptor tyrosine kinase (Ret) signaling is indispensable for their survival, migration and differentiation. Using microarray analysis and isolated NCCs, we found that 45 genes were differentially expressed after GDNF treatment (16 h), 29 of them were up-regulated including 8 previously undescribed genes. Prokineticin receptor 1 (PK-R1), a receptor for Prokineticins (Prok), was identified in our screen and shown to be consistently up-regulated by GDNF in enteric NCCs. Further, PK-R1 was persistently expressed at a lower level in the enteric ganglions of the c-Ret deficient mice when compared to that of the wild-type littermates. Subsequent functional analysis showed that GDNF potentiated the proliferative and differentiation effects of Prok-1 by up-regulating PK-R1 expression in enteric NCCs. In addition, expression analysis and gene knock-down experiments indicated that Prok-1 and GDNF signalings shared some common downstream targets. More importantly, Prok-1 could induce both proliferation and expression of differentiation markers of c-Ret deficient NCCs, suggesting that Prok-1 may also provide a complementary pathway to GDNF signaling. Taken together, these findings provide evidence that Prok-1 crosstalks with GDNF/Ret signaling and probably provides an additional layer of signaling refinement to maintain proliferation and differentiation of enteric NCCs. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68066
ISSN
2015 Impact Factor: 5.128
2015 SCImago Journal Rankings: 3.043
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNgan, ESWen_HK
dc.contributor.authorShum, CKYen_HK
dc.contributor.authorPoon, HCen_HK
dc.contributor.authorSham, MHen_HK
dc.contributor.authorGarciaBarcelo, MMen_HK
dc.contributor.authorLui, VCHen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T06:01:01Z-
dc.date.available2010-09-06T06:01:01Z-
dc.date.issued2008en_HK
dc.identifier.citationBiochimica Et Biophysica Acta - Molecular Cell Research, 2008, v. 1783 n. 3, p. 467-478en_HK
dc.identifier.issn0167-4889en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68066-
dc.description.abstractEnteric neural crest cells (NCC) are multipotent progenitors which give rise to neurons and glia of the enteric nervous system (ENS) during fetal development. Glial cell line-derived neurotrophic factor (GDNF)/RET receptor tyrosine kinase (Ret) signaling is indispensable for their survival, migration and differentiation. Using microarray analysis and isolated NCCs, we found that 45 genes were differentially expressed after GDNF treatment (16 h), 29 of them were up-regulated including 8 previously undescribed genes. Prokineticin receptor 1 (PK-R1), a receptor for Prokineticins (Prok), was identified in our screen and shown to be consistently up-regulated by GDNF in enteric NCCs. Further, PK-R1 was persistently expressed at a lower level in the enteric ganglions of the c-Ret deficient mice when compared to that of the wild-type littermates. Subsequent functional analysis showed that GDNF potentiated the proliferative and differentiation effects of Prok-1 by up-regulating PK-R1 expression in enteric NCCs. In addition, expression analysis and gene knock-down experiments indicated that Prok-1 and GDNF signalings shared some common downstream targets. More importantly, Prok-1 could induce both proliferation and expression of differentiation markers of c-Ret deficient NCCs, suggesting that Prok-1 may also provide a complementary pathway to GDNF signaling. Taken together, these findings provide evidence that Prok-1 crosstalks with GDNF/Ret signaling and probably provides an additional layer of signaling refinement to maintain proliferation and differentiation of enteric NCCs. © 2007 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbamcren_HK
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular Cell Researchen_HK
dc.rightsBiochimica et Biophysica Acta. Copyright © Elsevier BV.en_HK
dc.subjectGDNFen_HK
dc.subjectNeural crest cellen_HK
dc.subjectProk-1en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Differentiation - geneticsen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshEmbryo, Mammalianen_HK
dc.subject.meshEnteric Nervous System - embryologyen_HK
dc.subject.meshExtracellular Matrix Proteins - geneticsen_HK
dc.subject.meshGene Expression Profilingen_HK
dc.subject.meshGene Expression Regulation, Developmentalen_HK
dc.subject.meshGlial Cell Line-Derived Neurotrophic Factor - genetics - metabolism - physiologyen_HK
dc.subject.meshGlycoproteins - geneticsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Transgenicen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshNeural Crest - metabolism - physiologyen_HK
dc.subject.meshOligonucleotide Array Sequence Analysisen_HK
dc.subject.meshProto-Oncogene Proteins c-ret - geneticsen_HK
dc.subject.meshReceptors, G-Protein-Coupled - genetics - metabolismen_HK
dc.subject.meshVascular Endothelial Growth Factor, Endocrine-Gland-Derived - genetics - metabolism - physiologyen_HK
dc.subject.meshVasoactive Intestinal Peptide - geneticsen_HK
dc.titleProkineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3002&volume=1783&spage=467&epage=478&date=2008&atitle=Prokineticin-1+(Prok-1)+works+coordinately+with+glial+cell+line-derived+neurotrophic+factor+(GDNF)+to+mediate+proliferation+and+differentiation+of+enteric+neural+crest+cellsen_HK
dc.identifier.emailNgan, ESW: engan@hkucc.hku.hken_HK
dc.identifier.emailSham, MH: mhsham@hkucc.hku.hken_HK
dc.identifier.emailGarciaBarcelo, MM: mmgarcia@hkucc.hku.hken_HK
dc.identifier.emailLui, VCH: vchlui@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityNgan, ESW=rp00422en_HK
dc.identifier.authoritySham, MH=rp00380en_HK
dc.identifier.authorityGarciaBarcelo, MM=rp00445en_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbamcr.2007.09.005en_HK
dc.identifier.pmid18006159en_HK
dc.identifier.scopuseid_2-s2.0-38949084150en_HK
dc.identifier.hkuros140954en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38949084150&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1783en_HK
dc.identifier.issue3en_HK
dc.identifier.spage467en_HK
dc.identifier.epage478en_HK
dc.identifier.isiWOS:000254185100012-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridNgan, ESW=22234827500en_HK
dc.identifier.scopusauthoridShum, CKY=35286215500en_HK
dc.identifier.scopusauthoridPoon, HC=35084222000en_HK
dc.identifier.scopusauthoridSham, MH=7003729109en_HK
dc.identifier.scopusauthoridGarciaBarcelo, MM=6701767303en_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK

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