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Article: Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice

TitleAltered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice
Authors
Issue Date2004
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2004, v. 15 n. 3, p. 569-574 How to Cite?
AbstractMembrane-type-1 matrix metalloproteinase (MTI-MMP) knock-out (KO) mice fail to gain weight and die 3-4 weeks after birth. To understand the wasting phenotype in MTI-MMP-KO mice we studied the expression of some hypothalamic neuropeptides involved in control of appetite and body weight. In MTI-MMP-KO mice, neuronal perikarya in the arcuate nucleus displayed accumulations of NPY and agouti-related protein (AgRP) immunoreactivity (-ir). In contrast, NPY-ir and AgRP-ir were reduced in the projection areas of the arcuate neurons. NPYand AgRP are known to relay metabolic signals from the periphery into the brain to stimulate body weight gain. Their altered subcellular distribution suggests that MTI-MMP is involved in postnatal development of the arcuate NPY/ AgRP-system which may contribute to the generation of the wasting phenotype. © 2004 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/68064
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorByrne, LCen_HK
dc.contributor.authorZhou, Zen_HK
dc.contributor.authorTryggvason, Ken_HK
dc.contributor.authorHökfelt, Ten_HK
dc.contributor.authorFetissov, SOen_HK
dc.date.accessioned2010-09-06T06:01:00Z-
dc.date.available2010-09-06T06:01:00Z-
dc.date.issued2004en_HK
dc.identifier.citationNeuroreport, 2004, v. 15 n. 3, p. 569-574en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68064-
dc.description.abstractMembrane-type-1 matrix metalloproteinase (MTI-MMP) knock-out (KO) mice fail to gain weight and die 3-4 weeks after birth. To understand the wasting phenotype in MTI-MMP-KO mice we studied the expression of some hypothalamic neuropeptides involved in control of appetite and body weight. In MTI-MMP-KO mice, neuronal perikarya in the arcuate nucleus displayed accumulations of NPY and agouti-related protein (AgRP) immunoreactivity (-ir). In contrast, NPY-ir and AgRP-ir were reduced in the projection areas of the arcuate neurons. NPYand AgRP are known to relay metabolic signals from the periphery into the brain to stimulate body weight gain. Their altered subcellular distribution suggests that MTI-MMP is involved in postnatal development of the arcuate NPY/ AgRP-system which may contribute to the generation of the wasting phenotype. © 2004 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsNeuroreport. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAgouti-Related Proteinen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAppetite - genetics - physiologyen_HK
dc.subject.meshArcuate Nucleus - metabolismen_HK
dc.subject.meshBody Weight - genetics - physiologyen_HK
dc.subject.meshDNA Probesen_HK
dc.subject.meshHypothalamus - metabolismen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshIntercellular Signaling Peptides and Proteinsen_HK
dc.subject.meshMatrix Metalloproteinase 1 - geneticsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Knockouten_HK
dc.subject.meshNeural Pathways - metabolismen_HK
dc.subject.meshNeuropeptide Y - genetics - metabolismen_HK
dc.subject.meshPhenotypeen_HK
dc.subject.meshProteins - genetics - metabolismen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.titleAltered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4965&volume=15&issue=3&spage=569&epage=574&date=2004&atitle=Altered+NPY+and+AgRP+in+membrane+type-1+matrix+metalloproteinase-deficient+miceen_HK
dc.identifier.emailZhou, Z:zhongjun@hkucc.hku.hken_HK
dc.identifier.authorityZhou, Z=rp00503en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00001756-200403010-00037en_HK
dc.identifier.pmid15094525en_HK
dc.identifier.scopuseid_2-s2.0-1542267697en_HK
dc.identifier.hkuros88336en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1542267697&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue3en_HK
dc.identifier.spage569en_HK
dc.identifier.epage574en_HK
dc.identifier.isiWOS:000225140000037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridByrne, LC=8788855600en_HK
dc.identifier.scopusauthoridZhou, Z=8631856300en_HK
dc.identifier.scopusauthoridTryggvason, K=7102025185en_HK
dc.identifier.scopusauthoridHökfelt, T=7202608621en_HK
dc.identifier.scopusauthoridFetissov, SO=6701679259en_HK

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