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Article: Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels

TitlePresence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels
Authors
Issue Date2005
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
Citation
Blood, 2005, v. 106 n. 13, p. 4184-4190 How to Cite?
AbstractBone marrow (BM)-derived circulating endothelial precursor cells (CEPCs) have been reported to incorporate into newly formed blood vessels under physiologic and pathologic conditions. However, it is unknown if CEPCs contribute to lymphangiogenesis. Here we show that in a corneal lymphangiogenesis model of irradiated mice reconstituted with enhanced green fluorescent protein (EGFP)-positive donor bone marrow cells, CEPCs are present in the newly formed lymphatic vessels. Depletion of bone marrow cells by irradiation remarkably suppressed lymphangiogenesis in corneas implanted with fibroblast growth factor-2 (FGF-2). Further, transplantation of isolated EGFP-positive/vascular endothelial growth factor receptor-3-positive (EGFP +/VEGFR-3+) or EGFP+/VEGFR-2+ cell populations resulted in incorporation of EGFP+ cells into the newly formed lymphatic vessels. EGFP+/CEPCs were also present in peritumoral lymphatic vessels of a fibrosarcoma. These data suggest that BM-derived CEPCs may play a role in lymphvasculogenesis. © 2005 by The American Society of Hematology.
Persistent Identifierhttp://hdl.handle.net/10722/68039
ISSN
2015 Impact Factor: 11.841
2015 SCImago Journal Rankings: 6.395
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorReliga, Pen_HK
dc.contributor.authorCao, Ren_HK
dc.contributor.authorBjorndahl, Men_HK
dc.contributor.authorZhou, Zen_HK
dc.contributor.authorZhu, Zen_HK
dc.contributor.authorCao, Yen_HK
dc.date.accessioned2010-09-06T06:00:45Z-
dc.date.available2010-09-06T06:00:45Z-
dc.date.issued2005en_HK
dc.identifier.citationBlood, 2005, v. 106 n. 13, p. 4184-4190en_HK
dc.identifier.issn0006-4971en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68039-
dc.description.abstractBone marrow (BM)-derived circulating endothelial precursor cells (CEPCs) have been reported to incorporate into newly formed blood vessels under physiologic and pathologic conditions. However, it is unknown if CEPCs contribute to lymphangiogenesis. Here we show that in a corneal lymphangiogenesis model of irradiated mice reconstituted with enhanced green fluorescent protein (EGFP)-positive donor bone marrow cells, CEPCs are present in the newly formed lymphatic vessels. Depletion of bone marrow cells by irradiation remarkably suppressed lymphangiogenesis in corneas implanted with fibroblast growth factor-2 (FGF-2). Further, transplantation of isolated EGFP-positive/vascular endothelial growth factor receptor-3-positive (EGFP +/VEGFR-3+) or EGFP+/VEGFR-2+ cell populations resulted in incorporation of EGFP+ cells into the newly formed lymphatic vessels. EGFP+/CEPCs were also present in peritumoral lymphatic vessels of a fibrosarcoma. These data suggest that BM-derived CEPCs may play a role in lymphvasculogenesis. © 2005 by The American Society of Hematology.en_HK
dc.languageengen_HK
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/en_HK
dc.relation.ispartofBlooden_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBiological Markersen_HK
dc.subject.meshBone Marrow Cells - cytology - metabolismen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshEndothelial Cells - cytology - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlycoproteins - metabolismen_HK
dc.subject.meshGreen Fluorescent Proteins - metabolismen_HK
dc.subject.meshLeukemia, Lymphoid - metabolism - pathologyen_HK
dc.subject.meshLymphatic Vessels - cytology - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshReceptors, Vascular Endothelial Growth Factor - genetics - metabolismen_HK
dc.subject.meshStem Cells - cytology - metabolismen_HK
dc.titlePresence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vesselsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-4971&volume=106&issue=13&spage=4184&epage=90&date=2005&atitle=Presence+Of+Bone+Marrow-derived+Circulating+Progenitor+Endothelial+Cells+In+The+Newly+Formed+Lymphatic+Vesselsen_HK
dc.identifier.emailZhou, Z:zhongjun@hkucc.hku.hken_HK
dc.identifier.authorityZhou, Z=rp00503en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1182/blood-2005-01-0226en_HK
dc.identifier.pmid16141354-
dc.identifier.scopuseid_2-s2.0-28844505689en_HK
dc.identifier.hkuros100105en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-28844505689&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume106en_HK
dc.identifier.issue13en_HK
dc.identifier.spage4184en_HK
dc.identifier.epage4190en_HK
dc.identifier.isiWOS:000233925900032-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f100010191-
dc.identifier.scopusauthoridReliga, P=6603614167en_HK
dc.identifier.scopusauthoridCao, R=7103341338en_HK
dc.identifier.scopusauthoridBjorndahl, M=6506759393en_HK
dc.identifier.scopusauthoridZhou, Z=8631856300en_HK
dc.identifier.scopusauthoridZhu, Z=7404803288en_HK
dc.identifier.scopusauthoridCao, Y=7404524342en_HK

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