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Article: crm-1 facilitates BMP signaling to control body size in Caenorhabditis elegans

Titlecrm-1 facilitates BMP signaling to control body size in Caenorhabditis elegans
Authors
Issue Date2007
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
Citation
Developmental Biology, 2007, v. 311, p. 95-105 How to Cite?
AbstractWe have identified in Caenorhabditis elegans a homologue of the vertebrate Crim1, crm-1, which encodes a putative transmembrane protein with multiple cysteine-rich (CR) domains known to have bone morphogenetic proteins (BMPs) binding activity. Using the body morphology of C. elegans as an indicator, we showed that attenuation of crm-1 activity leads to a small body phenotype reminiscent of that of BMP pathway mutants. We showed that the crm-1 loss-of-function phenotype can be rescued by constitutive supply of sma-4 activity. crm-1 can enhance BMP signaling and this activity is dependent on the presence of the DBL-1 ligand and its receptors. crm-1 is expressed in neurons at the ventral nerve cord, where the DBL-1 ligand is produced. However, ectopic expression experiments reveal that crm-1 gene products act outside the DBL-1 producing cells and function non-autonomously to facilitate dbl/sma pathway signaling to control body size.
Persistent Identifierhttp://hdl.handle.net/10722/68036
ISSN
2015 Impact Factor: 3.155
2015 SCImago Journal Rankings: 2.554
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, YFen_HK
dc.contributor.authorKo, FCFen_HK
dc.contributor.authorCheah, KSEen_HK
dc.contributor.authorChow, KLen_HK
dc.date.accessioned2010-09-06T06:00:44Z-
dc.date.available2010-09-06T06:00:44Z-
dc.date.issued2007en_HK
dc.identifier.citationDevelopmental Biology, 2007, v. 311, p. 95-105en_HK
dc.identifier.issn0012-1606en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68036-
dc.description.abstractWe have identified in Caenorhabditis elegans a homologue of the vertebrate Crim1, crm-1, which encodes a putative transmembrane protein with multiple cysteine-rich (CR) domains known to have bone morphogenetic proteins (BMPs) binding activity. Using the body morphology of C. elegans as an indicator, we showed that attenuation of crm-1 activity leads to a small body phenotype reminiscent of that of BMP pathway mutants. We showed that the crm-1 loss-of-function phenotype can be rescued by constitutive supply of sma-4 activity. crm-1 can enhance BMP signaling and this activity is dependent on the presence of the DBL-1 ligand and its receptors. crm-1 is expressed in neurons at the ventral nerve cord, where the DBL-1 ligand is produced. However, ectopic expression experiments reveal that crm-1 gene products act outside the DBL-1 producing cells and function non-autonomously to facilitate dbl/sma pathway signaling to control body size.-
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbioen_HK
dc.relation.ispartofDevelopmental Biologyen_HK
dc.subject.meshBody Size-
dc.subject.meshBone Morphogenetic Proteins - metabolism-
dc.subject.meshCaenorhabditis elegans - embryology - metabolism-
dc.subject.meshCaenorhabditis elegans Proteins - genetics -metabolism-
dc.subject.meshMembrane Proteins - genetics - metabolism-
dc.titlecrm-1 facilitates BMP signaling to control body size in Caenorhabditis elegansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-1606&volume=311&spage=95&epage=105&date=2007&atitle=crm-1+facilitates+BMP+signaling+to+control+body+size+in+Caenorhabditis+elegansen_HK
dc.identifier.emailKo, FCF: bokcf@hkucc.hku.hken_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hkusua.hku.hken_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.ydbio.2007.08.016-
dc.identifier.pmid17869238-
dc.identifier.scopuseid_2-s2.0-35348853686-
dc.identifier.hkuros156760en_HK
dc.identifier.hkuros138292-
dc.identifier.isiWOS:000250703700008-

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