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- Publisher Website: 10.1196/annals.1299.066
- Scopus: eid_2-s2.0-1342326775
- PMID: 15033752
- WOS: WOS:000189446300066
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Article: The Overexpression of Bcl-2 Antagonizes the Proapoptotic Function of the Kappa-Opioid Receptor
Title | The Overexpression of Bcl-2 Antagonizes the Proapoptotic Function of the Kappa-Opioid Receptor |
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Authors | |
Keywords | Epithelial Opioid Receptor Staurosporine |
Issue Date | 2003 |
Publisher | Wiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1 |
Citation | Annals Of The New York Academy Of Sciences, 2003, v. 1010, p. 358-360 How to Cite? |
Abstract | Opioid receptors are G-protein-coupled cell-surface receptors that are mainly expressed in neuronal cells. Stimulation of the K-opioid receptor expressed by cultured human epithelial cancer cells promotes staurosporine-induced apoptosis. In this study, while Bcl-2 did not inhibit staurosporine-induced apoptosis, it did inhibit the κ-opioid receptor-mediated potentiation of apoptosis. The results suggest that Bcl-2 targets a step that is specific to the signaling pathway of the κ-opioid receptor. |
Persistent Identifier | http://hdl.handle.net/10722/68016 |
ISSN | 2023 Impact Factor: 4.1 2023 SCImago Journal Rankings: 1.416 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, N | en_HK |
dc.contributor.author | Diao, CT | en_HK |
dc.contributor.author | Wong, T | en_HK |
dc.date.accessioned | 2010-09-06T06:00:32Z | - |
dc.date.available | 2010-09-06T06:00:32Z | - |
dc.date.issued | 2003 | en_HK |
dc.identifier.citation | Annals Of The New York Academy Of Sciences, 2003, v. 1010, p. 358-360 | en_HK |
dc.identifier.issn | 0077-8923 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/68016 | - |
dc.description.abstract | Opioid receptors are G-protein-coupled cell-surface receptors that are mainly expressed in neuronal cells. Stimulation of the K-opioid receptor expressed by cultured human epithelial cancer cells promotes staurosporine-induced apoptosis. In this study, while Bcl-2 did not inhibit staurosporine-induced apoptosis, it did inhibit the κ-opioid receptor-mediated potentiation of apoptosis. The results suggest that Bcl-2 targets a step that is specific to the signaling pathway of the κ-opioid receptor. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Wiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1 | en_HK |
dc.relation.ispartof | Annals of the New York Academy of Sciences | en_HK |
dc.subject | Epithelial | - |
dc.subject | Opioid | - |
dc.subject | Receptor | - |
dc.subject | Staurosporine | - |
dc.subject.mesh | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | en_HK |
dc.subject.mesh | Apoptosis - drug effects - physiology | en_HK |
dc.subject.mesh | Cell Line, Tumor | en_HK |
dc.subject.mesh | Genes, bcl-2 | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Proto-Oncogene Proteins c-bcl-2 - genetics | en_HK |
dc.subject.mesh | Receptors, Opioid, kappa - drug effects - physiology | en_HK |
dc.subject.mesh | Staurosporine - pharmacology | en_HK |
dc.title | The Overexpression of Bcl-2 Antagonizes the Proapoptotic Function of the Kappa-Opioid Receptor | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0077-8923&volume=1010&spage=358&epage=260&date=2003&atitle=The+overexpression+of+Bcl-2+antagonizes+the+proapoptotic+function+of+the+kappa-opioid+receptor | en_HK |
dc.identifier.email | Wong, N:nswong@hkucc.hku.hk | en_HK |
dc.identifier.authority | Wong, N=rp00340 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1196/annals.1299.066 | en_HK |
dc.identifier.pmid | 15033752 | - |
dc.identifier.scopus | eid_2-s2.0-1342326775 | en_HK |
dc.identifier.hkuros | 88120 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-1342326775&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 1010 | en_HK |
dc.identifier.spage | 358 | en_HK |
dc.identifier.epage | 360 | en_HK |
dc.identifier.isi | WOS:000189446300066 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Wong, N=7202836641 | en_HK |
dc.identifier.scopusauthorid | Diao, CT=36939301100 | en_HK |
dc.identifier.scopusauthorid | Wong, T=7403531434 | en_HK |
dc.identifier.issnl | 0077-8923 | - |