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Article: The Overexpression of Bcl-2 Antagonizes the Proapoptotic Function of the Kappa-Opioid Receptor

TitleThe Overexpression of Bcl-2 Antagonizes the Proapoptotic Function of the Kappa-Opioid Receptor
Authors
Wong, NDiao, CTWong, T
KeywordsEpithelial
Opioid
Receptor
Staurosporine
Issue Date2003
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1
Citation
Annals Of The New York Academy Of Sciences, 2003, v. 1010, p. 358-360 How to Cite?
DOI: http://dx.doi.org/10.1196/annals.1299.066
AbstractOpioid receptors are G-protein-coupled cell-surface receptors that are mainly expressed in neuronal cells. Stimulation of the K-opioid receptor expressed by cultured human epithelial cancer cells promotes staurosporine-induced apoptosis. In this study, while Bcl-2 did not inhibit staurosporine-induced apoptosis, it did inhibit the κ-opioid receptor-mediated potentiation of apoptosis. The results suggest that Bcl-2 targets a step that is specific to the signaling pathway of the κ-opioid receptor.
Persistent Identifierhttp://hdl.handle.net/10722/68016
ISSN
0077-8923
2021 Impact Factor: 6.499
2020 SCImago Journal Rankings: 1.712
ISI Accession Number ID
WOS:000189446300066
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWong, Nen_HK
dc.contributor.authorDiao, CTen_HK
dc.contributor.authorWong, Ten_HK
dc.date.accessioned2010-09-06T06:00:32Z-
dc.date.available2010-09-06T06:00:32Z-
dc.date.issued2003en_HK
dc.identifier.citationAnnals Of The New York Academy Of Sciences, 2003, v. 1010, p. 358-360en_HK
dc.identifier.issn0077-8923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68016-
dc.description.abstractOpioid receptors are G-protein-coupled cell-surface receptors that are mainly expressed in neuronal cells. Stimulation of the K-opioid receptor expressed by cultured human epithelial cancer cells promotes staurosporine-induced apoptosis. In this study, while Bcl-2 did not inhibit staurosporine-induced apoptosis, it did inhibit the κ-opioid receptor-mediated potentiation of apoptosis. The results suggest that Bcl-2 targets a step that is specific to the signaling pathway of the κ-opioid receptor.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1en_HK
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_HK
dc.subjectEpithelial-
dc.subjectOpioid-
dc.subjectReceptor-
dc.subjectStaurosporine-
dc.subject.mesh3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacologyen_HK
dc.subject.meshApoptosis - drug effects - physiologyen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshGenes, bcl-2en_HK
dc.subject.meshHumansen_HK
dc.subject.meshProto-Oncogene Proteins c-bcl-2 - geneticsen_HK
dc.subject.meshReceptors, Opioid, kappa - drug effects - physiologyen_HK
dc.subject.meshStaurosporine - pharmacologyen_HK
dc.titleThe Overexpression of Bcl-2 Antagonizes the Proapoptotic Function of the Kappa-Opioid Receptoren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0077-8923&volume=1010&spage=358&epage=260&date=2003&atitle=The+overexpression+of+Bcl-2+antagonizes+the+proapoptotic+function+of+the+kappa-opioid+receptoren_HK
dc.identifier.emailWong, N:nswong@hkucc.hku.hken_HK
dc.identifier.authorityWong, N=rp00340en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1196/annals.1299.066en_HK
dc.identifier.pmid15033752-
dc.identifier.scopuseid_2-s2.0-1342326775en_HK
dc.identifier.hkuros88120en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1342326775&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1010en_HK
dc.identifier.spage358en_HK
dc.identifier.epage360en_HK
dc.identifier.isiWOS:000189446300066-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, N=7202836641en_HK
dc.identifier.scopusauthoridDiao, CT=36939301100en_HK
dc.identifier.scopusauthoridWong, T=7403531434en_HK
dc.identifier.issnl0077-8923-

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