Article: The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus

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TitleThe adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
AuthorsTanner, JA1
Zheng, BJ1
Zhou, J1
Watt, RM1
Jiang, JQ1
Wong, KL1
Lin, YP1
Lu, LY1
He, ML2
Kung, HF2
Kesel, AJ
Huang, JD1
Issue Date2005
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/chembiol
CitationChemistry And Biology, 2005, v. 12 n. 3, p. 303-311 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.chembiol.2005.01.006
AbstractBananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC 50 values in the range 0.5-3 μM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC 50 of less than 10 μM and a CC 50 of over 300 μM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication. © 2005 Elsevier Ltd All rights reserved.
ISSN1074-5521
2011 Impact Factor: 5.829
2011 SCImago Journal Rankings: 0.840
DOIhttp://dx.doi.org/10.1016/j.chembiol.2005.01.006
ISI Accession Number IDWOS:000228260000009
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTanner, JA
dc.contributor.authorZheng, BJ
dc.contributor.authorZhou, J
dc.contributor.authorWatt, RM
dc.contributor.authorJiang, JQ
dc.contributor.authorWong, KL
dc.contributor.authorLin, YP
dc.contributor.authorLu, LY
dc.contributor.authorHe, ML
dc.contributor.authorKung, HF
dc.contributor.authorKesel, AJ
dc.contributor.authorHuang, JD
dc.date.accessioned2010-09-06T06:00:29Z
dc.date.available2010-09-06T06:00:29Z
dc.date.issued2005
dc.description.abstractBananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC 50 values in the range 0.5-3 μM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC 50 of less than 10 μM and a CC 50 of over 300 μM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication. © 2005 Elsevier Ltd All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationChemistry And Biology, 2005, v. 12 n. 3, p. 303-311 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.chembiol.2005.01.006
dc.identifier.doihttp://dx.doi.org/10.1016/j.chembiol.2005.01.006
dc.identifier.epage311
dc.identifier.hkuros98284
dc.identifier.isiWOS:000228260000009
dc.identifier.issn1074-5521
2011 Impact Factor: 5.829
2011 SCImago Journal Rankings: 0.840
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid15797214
dc.identifier.scopuseid_2-s2.0-20144381480
dc.identifier.spage303
dc.identifier.urihttp://hdl.handle.net/10722/68011
dc.identifier.volume12
dc.languageeng
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/chembiol
dc.publisher.placeUnited States
dc.relation.ispartofChemistry and Biology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdamantane - analogs & derivatives - chemistry - pharmacology
dc.subject.meshAnimals
dc.subject.meshAntiviral Agents - chemistry - pharmacology
dc.subject.meshCells, Cultured
dc.subject.meshDNA Helicases - antagonists & inhibitors - metabolism
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshEnzyme Inhibitors - chemistry - pharmacology
dc.subject.meshMacaca mulatta
dc.subject.meshPyridines - chemistry - pharmacology
dc.subject.meshSARS Virus - drug effects - enzymology - physiology
dc.subject.meshVirus Replication - drug effects - physiology
dc.titleThe adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Chinese University of Hong Kong