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Article: The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus

TitleThe adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
Authors
Issue Date2005
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/chembiol
Citation
Chemistry And Biology, 2005, v. 12 n. 3, p. 303-311 How to Cite?
AbstractBananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC 50 values in the range 0.5-3 μM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC 50 of less than 10 μM and a CC 50 of over 300 μM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication. © 2005 Elsevier Ltd All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68011
ISSN
2014 Impact Factor: 6.645
2014 SCImago Journal Rankings: 2.534
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTanner, JAen_HK
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorZhou, Jen_HK
dc.contributor.authorWatt, RMen_HK
dc.contributor.authorJiang, JQen_HK
dc.contributor.authorWong, KLen_HK
dc.contributor.authorLin, YPen_HK
dc.contributor.authorLu, LYen_HK
dc.contributor.authorHe, MLen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorKesel, AJen_HK
dc.contributor.authorHuang, JDen_HK
dc.date.accessioned2010-09-06T06:00:29Z-
dc.date.available2010-09-06T06:00:29Z-
dc.date.issued2005en_HK
dc.identifier.citationChemistry And Biology, 2005, v. 12 n. 3, p. 303-311en_HK
dc.identifier.issn1074-5521en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68011-
dc.description.abstractBananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC 50 values in the range 0.5-3 μM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC 50 of less than 10 μM and a CC 50 of over 300 μM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication. © 2005 Elsevier Ltd All rights reserved.en_HK
dc.languageengen_HK
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/chembiolen_HK
dc.relation.ispartofChemistry and Biologyen_HK
dc.subject.meshAdamantane - analogs & derivatives - chemistry - pharmacologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntiviral Agents - chemistry - pharmacologyen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshDNA Helicases - antagonists & inhibitors - metabolismen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshEnzyme Inhibitors - chemistry - pharmacologyen_HK
dc.subject.meshMacaca mulattaen_HK
dc.subject.meshPyridines - chemistry - pharmacologyen_HK
dc.subject.meshSARS Virus - drug effects - enzymology - physiologyen_HK
dc.subject.meshVirus Replication - drug effects - physiologyen_HK
dc.titleThe adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1074-5521&volume=12&spage=303&epage=311&date=2005&atitle=The+adamantane-derived+bananins+are+potent+inhibitors+of+the+helicase+activities+and+replication+of+SARS+coronavirusen_HK
dc.identifier.emailTanner, JA:jatanner@hku.hken_HK
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.emailWatt, RM:rmwatt@hku.hken_HK
dc.identifier.emailHuang, JD:jdhuang@hkucc.hku.hken_HK
dc.identifier.authorityTanner, JA=rp00495en_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.identifier.authorityWatt, RM=rp00043en_HK
dc.identifier.authorityHuang, JD=rp00451en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.chembiol.2005.01.006en_HK
dc.identifier.pmid15797214en_HK
dc.identifier.scopuseid_2-s2.0-20144381480en_HK
dc.identifier.hkuros98284en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20144381480&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue3en_HK
dc.identifier.spage303en_HK
dc.identifier.epage311en_HK
dc.identifier.isiWOS:000228260000009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTanner, JA=35513993000en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridZhou, J=7405550773en_HK
dc.identifier.scopusauthoridWatt, RM=7102907536en_HK
dc.identifier.scopusauthoridJiang, JQ=8591934900en_HK
dc.identifier.scopusauthoridWong, KL=7404758889en_HK
dc.identifier.scopusauthoridLin, YP=8591935100en_HK
dc.identifier.scopusauthoridLu, LY=8686996700en_HK
dc.identifier.scopusauthoridHe, ML=35080389700en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridKesel, AJ=6603578473en_HK
dc.identifier.scopusauthoridHuang, JD=8108660600en_HK

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