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Article: The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
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TitleThe adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
 
AuthorsTanner, JA1
Zheng, BJ1
Zhou, J1
Watt, RM1
Jiang, JQ1
Wong, KL1
Lin, YP1
Lu, LY1
He, ML2
Kung, HF2
Kesel, AJ
Huang, JD1
 
Issue Date2005
 
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/chembiol
 
CitationChemistry And Biology, 2005, v. 12 n. 3, p. 303-311 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.chembiol.2005.01.006
 
AbstractBananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC 50 values in the range 0.5-3 μM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC 50 of less than 10 μM and a CC 50 of over 300 μM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication. © 2005 Elsevier Ltd All rights reserved.
 
ISSN1074-5521
2012 Impact Factor: 6.157
2012 SCImago Journal Rankings: 2.258
 
DOIhttp://dx.doi.org/10.1016/j.chembiol.2005.01.006
 
ISI Accession Number IDWOS:000228260000009
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTanner, JA
 
dc.contributor.authorZheng, BJ
 
dc.contributor.authorZhou, J
 
dc.contributor.authorWatt, RM
 
dc.contributor.authorJiang, JQ
 
dc.contributor.authorWong, KL
 
dc.contributor.authorLin, YP
 
dc.contributor.authorLu, LY
 
dc.contributor.authorHe, ML
 
dc.contributor.authorKung, HF
 
dc.contributor.authorKesel, AJ
 
dc.contributor.authorHuang, JD
 
dc.date.accessioned2010-09-06T06:00:29Z
 
dc.date.available2010-09-06T06:00:29Z
 
dc.date.issued2005
 
dc.description.abstractBananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC 50 values in the range 0.5-3 μM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC 50 of less than 10 μM and a CC 50 of over 300 μM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication. © 2005 Elsevier Ltd All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationChemistry And Biology, 2005, v. 12 n. 3, p. 303-311 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.chembiol.2005.01.006
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.chembiol.2005.01.006
 
dc.identifier.epage311
 
dc.identifier.hkuros98284
 
dc.identifier.isiWOS:000228260000009
 
dc.identifier.issn1074-5521
2012 Impact Factor: 6.157
2012 SCImago Journal Rankings: 2.258
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid15797214
 
dc.identifier.scopuseid_2-s2.0-20144381480
 
dc.identifier.spage303
 
dc.identifier.urihttp://hdl.handle.net/10722/68011
 
dc.identifier.volume12
 
dc.languageeng
 
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/chembiol
 
dc.publisher.placeUnited States
 
dc.relation.ispartofChemistry and Biology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdamantane - analogs & derivatives - chemistry - pharmacology
 
dc.subject.meshAnimals
 
dc.subject.meshAntiviral Agents - chemistry - pharmacology
 
dc.subject.meshCells, Cultured
 
dc.subject.meshDNA Helicases - antagonists & inhibitors - metabolism
 
dc.subject.meshDose-Response Relationship, Drug
 
dc.subject.meshEnzyme Inhibitors - chemistry - pharmacology
 
dc.subject.meshMacaca mulatta
 
dc.subject.meshPyridines - chemistry - pharmacology
 
dc.subject.meshSARS Virus - drug effects - enzymology - physiology
 
dc.subject.meshVirus Replication - drug effects - physiology
 
dc.titleThe adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Chinese University of Hong Kong