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Article: Inhibition of β-ionone on SGC-7901 cell proliferation and upregulation of metalloproteinases-1 and -2 expression

TitleInhibition of β-ionone on SGC-7901 cell proliferation and upregulation of metalloproteinases-1 and -2 expression
Authors
Issue Date2004
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2004, v. 10 n. 2, p. 167-171 How to Cite?
AbstractAim: To observe the effect of β-ionone on the proliferation of human gastric adenocarcinoma cell line SGC-7901 and the inhibition of metalloproteinase. Methods: Using growth inhibition, Zymograms assays and reverse transcription-polymerase-chain reaction (RT-PCR), we examined cell growth rates, activities of matrix metalloproteinases-2 (MMP-2) and -9 (MMP-9), and expression of metalloproteinases-1 (TIMP-1) and -2 (TIMP-2) in SGC-7901 cells after the treatment with β-ionone for 24 h and 48 h, respectively. Results: β-Ionone had an inhibitory effect on the growth of SGC-7901 cells. Eight days after the treatment with β-ionone at concentrations of 25, 50, 100 and 200 μmol/L, the inhibition rates were 25.9%, 28.2%, 74.4% and 90.1%, respectively. The IC50 value of β-ionone for SGC-7901 cells was estimated to be 89 μmol/L. The effects of β-ionone on MMP-2 and MMP-9 activities in SGC-7901 cells were not observed. However, the levels of TIMP-1 and TIMP-2 transcripts were elevated in cells treated with β-ionone in a dose-dependent manner. Conclusion: β-Ionone can inhibit the proliferation of SGC-7901 cells, upregulate the expression of TIMP-1 and TIMP-2 expression, and may influence metastasis of cancer.
Persistent Identifierhttp://hdl.handle.net/10722/68009
ISSN
2015 Impact Factor: 2.787
2015 SCImago Journal Rankings: 1.076
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, JRen_HK
dc.contributor.authorYang, BFen_HK
dc.contributor.authorChen, BQen_HK
dc.contributor.authorYang, YMen_HK
dc.contributor.authorDong, HWen_HK
dc.contributor.authorSong, YQen_HK
dc.date.accessioned2010-09-06T06:00:27Z-
dc.date.available2010-09-06T06:00:27Z-
dc.date.issued2004en_HK
dc.identifier.citationWorld Journal Of Gastroenterology, 2004, v. 10 n. 2, p. 167-171en_HK
dc.identifier.issn1007-9327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68009-
dc.description.abstractAim: To observe the effect of β-ionone on the proliferation of human gastric adenocarcinoma cell line SGC-7901 and the inhibition of metalloproteinase. Methods: Using growth inhibition, Zymograms assays and reverse transcription-polymerase-chain reaction (RT-PCR), we examined cell growth rates, activities of matrix metalloproteinases-2 (MMP-2) and -9 (MMP-9), and expression of metalloproteinases-1 (TIMP-1) and -2 (TIMP-2) in SGC-7901 cells after the treatment with β-ionone for 24 h and 48 h, respectively. Results: β-Ionone had an inhibitory effect on the growth of SGC-7901 cells. Eight days after the treatment with β-ionone at concentrations of 25, 50, 100 and 200 μmol/L, the inhibition rates were 25.9%, 28.2%, 74.4% and 90.1%, respectively. The IC50 value of β-ionone for SGC-7901 cells was estimated to be 89 μmol/L. The effects of β-ionone on MMP-2 and MMP-9 activities in SGC-7901 cells were not observed. However, the levels of TIMP-1 and TIMP-2 transcripts were elevated in cells treated with β-ionone in a dose-dependent manner. Conclusion: β-Ionone can inhibit the proliferation of SGC-7901 cells, upregulate the expression of TIMP-1 and TIMP-2 expression, and may influence metastasis of cancer.en_HK
dc.languageengen_HK
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_HK
dc.relation.ispartofWorld Journal of Gastroenterologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdenocarcinomaen_HK
dc.subject.meshCell Division - drug effectsen_HK
dc.subject.meshCell Line, Tumor - cytology - drug effects - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMatrix Metalloproteinase 1 - antagonists & inhibitors - metabolismen_HK
dc.subject.meshMatrix Metalloproteinase 2 - antagonists & inhibitors - metabolismen_HK
dc.subject.meshNorisoprenoids - pharmacologyen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshStomach Neoplasmsen_HK
dc.subject.meshTissue Inhibitor of Metalloproteinase-1 - geneticsen_HK
dc.subject.meshTissue Inhibitor of Metalloproteinase-2 - geneticsen_HK
dc.subject.meshUp-Regulation - drug effectsen_HK
dc.titleInhibition of β-ionone on SGC-7901 cell proliferation and upregulation of metalloproteinases-1 and -2 expressionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1007-9327&volume=10&issue=2&spage=167&epage=171&date=2004&atitle=Inhibition+of+β-ionone+on+SGC-7901+cell+proliferation+and+upregulation+of+metalloproteinases-1+and+-2+expression.+en_HK
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3748/wjg.v10.i2.167-
dc.identifier.pmid14716815-
dc.identifier.scopuseid_2-s2.0-1042304327en_HK
dc.identifier.hkuros88161en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1042304327&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue2en_HK
dc.identifier.spage167en_HK
dc.identifier.epage171en_HK
dc.identifier.isiWOS:000188459300003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, JR=26637082300en_HK
dc.identifier.scopusauthoridYang, BF=7404472748en_HK
dc.identifier.scopusauthoridChen, BQ=25647470000en_HK
dc.identifier.scopusauthoridYang, YM=7409385456en_HK
dc.identifier.scopusauthoridDong, HW=35749869200en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK

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