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Article: Crystallization of urinary calcium oxalate at standardized osmolality and pH in the frozen state

TitleCrystallization of urinary calcium oxalate at standardized osmolality and pH in the frozen state
Authors
Issue Date1994
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cca
Citation
Clinica Chimica Acta, 1994, v. 231 n. 1, p. 11-22 How to Cite?
AbstractThe potential of whole urine of stone-formers and normal controls to precipitate crystals of calcium oxalate dihydrate from ions endogenous in urine was investigated by the method of rapid evaporation to 1250 mOsm/kg and subsequent freezing. Over 90% incidence in crystallization was achieved in the two groups. When the population density and size of these crystals were compared, it was found that 50% of urine samples from stone formers (30-50 years of age) were rich in crystal-nucleating and growth-inhibiting factors and the other 50% were not different from normal controls. These effects were observed when polyanionic macromolecules recovered from pooled urine samples of stone-formers or normal controls were dissolved in urine ultrafiltrate and similarly tested. That the urinary polyanions were the active modifiers in the test system was further corroborated by the reversal of crystallization activity of urine samples and the urinary polyanions after they had been through an acidification-reneutralization procedure. The urinary polyanionic macromolecules were found, after enzymatic and/or chemical treatment, to contain chondroitin sulphates, dermatan sulphates, heparan sulphates and glycoproteins.
Persistent Identifierhttp://hdl.handle.net/10722/68007
ISSN
2015 Impact Factor: 2.799
2015 SCImago Journal Rankings: 1.040
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGohel, MDIen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorLi, MKen_HK
dc.date.accessioned2010-09-06T06:00:26Z-
dc.date.available2010-09-06T06:00:26Z-
dc.date.issued1994en_HK
dc.identifier.citationClinica Chimica Acta, 1994, v. 231 n. 1, p. 11-22en_HK
dc.identifier.issn0009-8981en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68007-
dc.description.abstractThe potential of whole urine of stone-formers and normal controls to precipitate crystals of calcium oxalate dihydrate from ions endogenous in urine was investigated by the method of rapid evaporation to 1250 mOsm/kg and subsequent freezing. Over 90% incidence in crystallization was achieved in the two groups. When the population density and size of these crystals were compared, it was found that 50% of urine samples from stone formers (30-50 years of age) were rich in crystal-nucleating and growth-inhibiting factors and the other 50% were not different from normal controls. These effects were observed when polyanionic macromolecules recovered from pooled urine samples of stone-formers or normal controls were dissolved in urine ultrafiltrate and similarly tested. That the urinary polyanions were the active modifiers in the test system was further corroborated by the reversal of crystallization activity of urine samples and the urinary polyanions after they had been through an acidification-reneutralization procedure. The urinary polyanionic macromolecules were found, after enzymatic and/or chemical treatment, to contain chondroitin sulphates, dermatan sulphates, heparan sulphates and glycoproteins.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ccaen_HK
dc.relation.ispartofClinica Chimica Actaen_HK
dc.rightsClinica Chimica Acta. Copyright © Elsevier BV.en_HK
dc.subject.meshAcids - chemistryen_HK
dc.subject.meshAdulten_HK
dc.subject.meshCalcium Oxalate - chemistry - urineen_HK
dc.subject.meshCrystallizationen_HK
dc.subject.meshFreezingen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydrogen-Ion Concentrationen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOsmolar Concentrationen_HK
dc.subject.meshTemperatureen_HK
dc.subject.meshUrinary Calculi - chemistryen_HK
dc.titleCrystallization of urinary calcium oxalate at standardized osmolality and pH in the frozen stateen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-8981&volume=231&spage=11&epage=22&date=1994&atitle=Crystallization+of+urinary+calcium+oxalate+at+standardized+osmolality+and+pH+in+the+frozen+stateen_HK
dc.identifier.emailShum, DKY:shumdkhk@hkucc.hku.hken_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0009-8981(94)90249-6en_HK
dc.identifier.pmid7704943-
dc.identifier.scopuseid_2-s2.0-0028138296en_HK
dc.identifier.hkuros1904en_HK
dc.identifier.volume231en_HK
dc.identifier.issue1en_HK
dc.identifier.spage11en_HK
dc.identifier.epage22en_HK
dc.identifier.isiWOS:A1994QA83200002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridGohel, MDI=7004532182en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridLi, MK=26021958200en_HK

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