File Download
  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Article: Lithium ion alters Ins(1,4,5)P3 production and mobilisation of intracellular free calcium in k-agonist stimulated rat ventricular myocytes

TitleLithium ion alters Ins(1,4,5)P3 production and mobilisation of intracellular free calcium in k-agonist stimulated rat ventricular myocytes
Authors
KeywordsLithium
Dynorphin1-13
Inositol 1,4,5-trisphosphate
Calcium
Myocytes
Issue Date1995
PublisherCognizant Communication Corporation. The Journal's web site is located at https://www.cognizantcommunication.com/component/virtuemart/?page=shop.product_details&flypage=flypage.tpl&product_id=7
Citation
Analgesia, 1995, v. 1 n. 4-6, p. 842-845 How to Cite?
AbstractThe effect of lithium ion on the generation of inositol phosphates and the mobilisation of intracellular free calcium in isolated adult rat ventricular myocytes stimulated with k-agonist was studied. Dynorphin1-13 stimulated an increase in the levels of Inositol 1,4,5-trisphosphate (InsP3) and intracellular free calcium ([Ca2+ ]i). Preincubation of the ventricular myocytes with lOmM Li+ for 20 minutes prior to stimulation by dynorphin1-13 reduce the increase of both InsP3 and [Ca2+]i. This effect of Li+ was not seen if 5mM inositol was also present during preincubation. It is concluded that (1) the inhibition of the k-agonist stimulated increase in InsP3 and [Ca2+]i, in Li+-pretreated ventricular myocytes was a result of a depletion of intracellular inositol, due probably to the inhibition by Li+ of inositol monophosphatase which participates in the recycling of intracellular inositol, and (2) the k-agonist induced increase in [Ca2+]i is a consequence of the production of InsP3 since altering the kinetics of production of this compound also altered [Ca2+]i.
Persistent Identifierhttp://hdl.handle.net/10722/68002
ISSN

 

DC FieldValueLanguage
dc.contributor.authorWong, NSen_HK
dc.contributor.authorSheng, ZJen_HK
dc.contributor.authorTai, KKen_HK
dc.contributor.authorBian, CFen_HK
dc.contributor.authorWong, TMen_HK
dc.date.accessioned2010-09-06T06:00:23Z-
dc.date.available2010-09-06T06:00:23Z-
dc.date.issued1995en_HK
dc.identifier.citationAnalgesia, 1995, v. 1 n. 4-6, p. 842-845en_HK
dc.identifier.issn1071-569Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68002-
dc.description.abstractThe effect of lithium ion on the generation of inositol phosphates and the mobilisation of intracellular free calcium in isolated adult rat ventricular myocytes stimulated with k-agonist was studied. Dynorphin1-13 stimulated an increase in the levels of Inositol 1,4,5-trisphosphate (InsP3) and intracellular free calcium ([Ca2+ ]i). Preincubation of the ventricular myocytes with lOmM Li+ for 20 minutes prior to stimulation by dynorphin1-13 reduce the increase of both InsP3 and [Ca2+]i. This effect of Li+ was not seen if 5mM inositol was also present during preincubation. It is concluded that (1) the inhibition of the k-agonist stimulated increase in InsP3 and [Ca2+]i, in Li+-pretreated ventricular myocytes was a result of a depletion of intracellular inositol, due probably to the inhibition by Li+ of inositol monophosphatase which participates in the recycling of intracellular inositol, and (2) the k-agonist induced increase in [Ca2+]i is a consequence of the production of InsP3 since altering the kinetics of production of this compound also altered [Ca2+]i.-
dc.languageengen_HK
dc.publisherCognizant Communication Corporation. The Journal's web site is located at https://www.cognizantcommunication.com/component/virtuemart/?page=shop.product_details&flypage=flypage.tpl&product_id=7en_HK
dc.relation.ispartofAnalgesiaen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_HK
dc.subjectLithium-
dc.subjectDynorphin1-13-
dc.subjectInositol 1,4,5-trisphosphate-
dc.subjectCalcium-
dc.subjectMyocytes-
dc.titleLithium ion alters Ins(1,4,5)P3 production and mobilisation of intracellular free calcium in k-agonist stimulated rat ventricular myocytesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-2409&volume=&spage=&epage=&date=1994&atitle=Lithium+ion+alters+Ins(1,4,5)P3+production+and+mobilisation+of+intracellular+free+calcium+in+k-agonist+stimulated+rat+ventricular+myocytesen_HK
dc.identifier.emailWong, NS: nswong@hkucc.hku.hken_HK
dc.identifier.emailWong, TM: wongtakm@hkucc.hku.hk-
dc.identifier.authorityWong, NS=rp00340en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros6992en_HK
dc.identifier.hkuros15436-
dc.identifier.volume1-
dc.identifier.issue4-6-
dc.identifier.spage842-
dc.identifier.epage845-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats