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Article: Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice

TitleDelayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice
Authors
Issue Date2003
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03008207.asp
Citation
Connective Tissue Research, 2003, v. 44 SUPPL. 1, p. 300-304 How to Cite?
AbstractMembrane-type 1 matrix metalloproteinase (MT1-MMP) is expressed highly in mineralizing tissues including bones and teeth. Mice deficient in MT1-MMP (-/-) display severe defects in skeletal development including dwarfism, osteopenia, and craniofacial abnormalities. Death occurs in these mice by about 3 weeks of age. Since MT1-MMP is expressed by the ameloblasts of the enamel organ and by the odontoblasts of the dental papilla, we asked if the developing teeth were adversely affected in the knockout animals. Molars from MT1-MMP -/- mice and controls were examined by histological, X-ray, and SEM analysis at 4, 18-20, and 25 days of postnatal development. At 4 days of development the molars from the -/- mice appeared histologically normal. At 18-20 days of development, the first molars of the -/- mice had apparently normal tooth crowns with normal dentin and enamel; however, the roots were truncated and the teeth had not yet erupted. In contrast to the -/- mice, the first molars of the 18-20-day control animals had erupted. SEM analysis of a -/- first molar and incisor revealed a normal enamel prism pattern. However, X-ray analysis demonstrated that tooth eruption was delayed by approximately 5 days and that the tooth roots were abnormally short in the knockout animals. Since MT1-MMP-deficient mice have been demonstrated to display a generalized increase in bone resorption, these data suggest that inefficient growth of bone surrounding the tooth root complex causes a delay in tooth eruption.
Persistent Identifierhttp://hdl.handle.net/10722/68000
ISSN
2015 Impact Factor: 1.411
2015 SCImago Journal Rankings: 0.622
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBartlett, JDen_HK
dc.contributor.authorZhou, Zen_HK
dc.contributor.authorSkobe, Zen_HK
dc.contributor.authorDobeck, JMen_HK
dc.contributor.authorTryggvason, Ken_HK
dc.date.accessioned2010-09-06T06:00:22Z-
dc.date.available2010-09-06T06:00:22Z-
dc.date.issued2003en_HK
dc.identifier.citationConnective Tissue Research, 2003, v. 44 SUPPL. 1, p. 300-304en_HK
dc.identifier.issn0300-8207en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68000-
dc.description.abstractMembrane-type 1 matrix metalloproteinase (MT1-MMP) is expressed highly in mineralizing tissues including bones and teeth. Mice deficient in MT1-MMP (-/-) display severe defects in skeletal development including dwarfism, osteopenia, and craniofacial abnormalities. Death occurs in these mice by about 3 weeks of age. Since MT1-MMP is expressed by the ameloblasts of the enamel organ and by the odontoblasts of the dental papilla, we asked if the developing teeth were adversely affected in the knockout animals. Molars from MT1-MMP -/- mice and controls were examined by histological, X-ray, and SEM analysis at 4, 18-20, and 25 days of postnatal development. At 4 days of development the molars from the -/- mice appeared histologically normal. At 18-20 days of development, the first molars of the -/- mice had apparently normal tooth crowns with normal dentin and enamel; however, the roots were truncated and the teeth had not yet erupted. In contrast to the -/- mice, the first molars of the 18-20-day control animals had erupted. SEM analysis of a -/- first molar and incisor revealed a normal enamel prism pattern. However, X-ray analysis demonstrated that tooth eruption was delayed by approximately 5 days and that the tooth roots were abnormally short in the knockout animals. Since MT1-MMP-deficient mice have been demonstrated to display a generalized increase in bone resorption, these data suggest that inefficient growth of bone surrounding the tooth root complex causes a delay in tooth eruption.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03008207.aspen_HK
dc.relation.ispartofConnective Tissue Researchen_HK
dc.rightsConnective Tissue Research. Copyright © Informa Healthcare.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshCalcification, Physiologic - physiologyen_HK
dc.subject.meshDental Enamel - enzymology - ultrastructureen_HK
dc.subject.meshMatrix Metalloproteinase 14en_HK
dc.subject.meshMatrix Metalloproteinases, Membrane-Associateden_HK
dc.subject.meshMetalloendopeptidases - deficiency - genetics - metabolismen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Knockouten_HK
dc.subject.meshMicroscopy, Electron, Scanningen_HK
dc.subject.meshMolar - enzymology - growth & development - pathologyen_HK
dc.subject.meshTooth Eruption - physiologyen_HK
dc.subject.meshTooth Root - growth & development - pathologyen_HK
dc.titleDelayed tooth eruption in membrane type-1 matrix metalloproteinase deficient miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-8207&volume=44&issue=Suppl 1&spage=1&epage=5&date=2003&atitle=Delayed+Tooth+Eruption+in+Membrane+Type-1+Matrix+Metalloproteinase+Deficient+Mice++++en_HK
dc.identifier.emailZhou, Z:zhongjun@hkucc.hku.hken_HK
dc.identifier.authorityZhou, Z=rp00503en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12952213-
dc.identifier.scopuseid_2-s2.0-0037240958en_HK
dc.identifier.hkuros84066en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037240958&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issueSUPPL. 1en_HK
dc.identifier.spage300en_HK
dc.identifier.epage304en_HK
dc.identifier.isiWOS:000181811000050-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBartlett, JD=26323989100en_HK
dc.identifier.scopusauthoridZhou, Z=8631856300en_HK
dc.identifier.scopusauthoridSkobe, Z=7004153003en_HK
dc.identifier.scopusauthoridDobeck, JM=6602959469en_HK
dc.identifier.scopusauthoridTryggvason, K=7102025185en_HK

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