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Article: Detailed deletion mapping on the short arm of chromosome 3 in nasopharyngeal carcinomas

TitleDetailed deletion mapping on the short arm of chromosome 3 in nasopharyngeal carcinomas
Authors
Keywordsallelic loss
chromosome 3p
microsatellite polymorphic markers
nasopharyngeal carcinoma
Issue Date1994
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/
Citation
International Journal Of Oncology, 1994, v. 4 n. 6, p. 1359-1364 How to Cite?
AbstractAllelic loss on the short arm of chromosome 3 is one of the most consistent molecular genetic alterations observed in primary nasopharyngeal carcinoma (NPC). Detailed mapping of the region of common deletion on chromosome 3p will help to locate the site of candidate tumor suppressor gene(s) involved in the pathogenesis of NPC. We have examined allelic deletion in 27 primary undifferentiated NPC at 11 chromosomal loci (spanning from 3p13-3p25) using microsatellite polymorphic markers. Allelic loss was observed in 18 of 27 primary tumors (67%) when comparing tumor DNA with normal constitutional DNA of the same patient. Among these 18 cases, 10 showed allelic loss in all informative loci of chromosome 3p and 8 showed partial or interstitial deletion. The highest frequency of allelic loss was found in three loci, D3S1038 (52%), D3S1228 (50%) and D3S659 (50%). In 5 of the 8 cases with partial deletion of chromosome 3p, a common deletion region within 3p13 to 3p14.3, flanked by two loci, D3S1079 (3p13) proximally and D3S1228 (3p14.1-14.3) distally, was identified. These results suggest strongly the presence of tumor suppressor gene(s) within the 3p13 to 3p14.3 region, the deletion of which represent a critical event in the development of NPC. In the remaining 3 cases with partial chromosomal deletion, the pattern of allelic loss suggests the presence of two other regions of deletion distal to the commonly deleted region (3p13-14.3) identified. The presence of multiple deleted regions on chromosome 3p in NPC suggests that more than one tumor suppressor gene on 3p may be involved in the development of NPC.
Persistent Identifierhttp://hdl.handle.net/10722/67981
ISSN
2015 Impact Factor: 3.018
2015 SCImago Journal Rankings: 1.270
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLo, KWen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorLeung, SFen_HK
dc.contributor.authorChoi, PHKen_HK
dc.contributor.authorLee, JCKen_HK
dc.contributor.authorHuang, DPen_HK
dc.date.accessioned2010-09-06T06:00:02Z-
dc.date.available2010-09-06T06:00:02Z-
dc.date.issued1994en_HK
dc.identifier.citationInternational Journal Of Oncology, 1994, v. 4 n. 6, p. 1359-1364en_HK
dc.identifier.issn1019-6439en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67981-
dc.description.abstractAllelic loss on the short arm of chromosome 3 is one of the most consistent molecular genetic alterations observed in primary nasopharyngeal carcinoma (NPC). Detailed mapping of the region of common deletion on chromosome 3p will help to locate the site of candidate tumor suppressor gene(s) involved in the pathogenesis of NPC. We have examined allelic deletion in 27 primary undifferentiated NPC at 11 chromosomal loci (spanning from 3p13-3p25) using microsatellite polymorphic markers. Allelic loss was observed in 18 of 27 primary tumors (67%) when comparing tumor DNA with normal constitutional DNA of the same patient. Among these 18 cases, 10 showed allelic loss in all informative loci of chromosome 3p and 8 showed partial or interstitial deletion. The highest frequency of allelic loss was found in three loci, D3S1038 (52%), D3S1228 (50%) and D3S659 (50%). In 5 of the 8 cases with partial deletion of chromosome 3p, a common deletion region within 3p13 to 3p14.3, flanked by two loci, D3S1079 (3p13) proximally and D3S1228 (3p14.1-14.3) distally, was identified. These results suggest strongly the presence of tumor suppressor gene(s) within the 3p13 to 3p14.3 region, the deletion of which represent a critical event in the development of NPC. In the remaining 3 cases with partial chromosomal deletion, the pattern of allelic loss suggests the presence of two other regions of deletion distal to the commonly deleted region (3p13-14.3) identified. The presence of multiple deleted regions on chromosome 3p in NPC suggests that more than one tumor suppressor gene on 3p may be involved in the development of NPC.en_HK
dc.languageengen_HK
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/en_HK
dc.relation.ispartofInternational Journal of Oncologyen_HK
dc.subjectallelic lossen_HK
dc.subjectchromosome 3pen_HK
dc.subjectmicrosatellite polymorphic markersen_HK
dc.subjectnasopharyngeal carcinomaen_HK
dc.titleDetailed deletion mapping on the short arm of chromosome 3 in nasopharyngeal carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1019-6439&volume=4&issue=6&spage=1359&epage=1364&date=1994&atitle=Detailed+deletion+mapping+on+the+short+arm+of+chromosome+3+in+nasopharyngeal+carcinomasen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid21567062-
dc.identifier.scopuseid_2-s2.0-0028239769en_HK
dc.identifier.hkuros4708en_HK
dc.identifier.volume4en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1359en_HK
dc.identifier.epage1364en_HK
dc.identifier.isiWOS:A1994NN51500032-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridLo, KW=7402101603en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridLeung, SF=7202044876en_HK
dc.identifier.scopusauthoridChoi, PHK=7102909162en_HK
dc.identifier.scopusauthoridLee, JCK=7601456915en_HK
dc.identifier.scopusauthoridHuang, DP=7403891486en_HK

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