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Article: Regenerative capacity of retinal ganglion cells in mammals

TitleRegenerative capacity of retinal ganglion cells in mammals
Authors
Issue Date1998
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/visres
Citation
Vision Research, 1998, v. 38 n. 10, p. 1525-1535 How to Cite?
AbstractRetinal ganglion cells (RGCs) and their projections in the optic nerve offer a convenient model to study survival and regeneration of mammalian central nervous system (CNS) nerve cells following injury. Possible factors affecting the death of RGCs following axotomy and various approaches to rescue the axotomized RGCs are discussed. In addition, two main strategies currently used to enhance axonal regeneration of damaged RGCs are described. The first focuses on overcoming the unfavorable extrinsic CNS environment and the second concentrates on upregulating the intrinsic growth potential of RGCs. Thus, the failure or success of RGC axonal regrowth after injury depends on the complicated interplay between the extrinsic and intrinsic factors.
Persistent Identifierhttp://hdl.handle.net/10722/67980
ISSN
2015 Impact Factor: 1.776
2015 SCImago Journal Rankings: 0.957
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSo, KFen_HK
dc.contributor.authorYip, HKen_HK
dc.date.accessioned2010-09-06T06:00:01Z-
dc.date.available2010-09-06T06:00:01Z-
dc.date.issued1998en_HK
dc.identifier.citationVision Research, 1998, v. 38 n. 10, p. 1525-1535en_HK
dc.identifier.issn0042-6989en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67980-
dc.description.abstractRetinal ganglion cells (RGCs) and their projections in the optic nerve offer a convenient model to study survival and regeneration of mammalian central nervous system (CNS) nerve cells following injury. Possible factors affecting the death of RGCs following axotomy and various approaches to rescue the axotomized RGCs are discussed. In addition, two main strategies currently used to enhance axonal regeneration of damaged RGCs are described. The first focuses on overcoming the unfavorable extrinsic CNS environment and the second concentrates on upregulating the intrinsic growth potential of RGCs. Thus, the failure or success of RGC axonal regrowth after injury depends on the complicated interplay between the extrinsic and intrinsic factors.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/visresen_HK
dc.relation.ispartofVision Researchen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAxons - physiologyen_HK
dc.subject.meshAxotomyen_HK
dc.subject.meshCell Survivalen_HK
dc.subject.meshNerve Growth Factors - pharmacologyen_HK
dc.subject.meshNerve Regenerationen_HK
dc.subject.meshRegenerationen_HK
dc.subject.meshRetinal Ganglion Cells - physiologyen_HK
dc.titleRegenerative capacity of retinal ganglion cells in mammalsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0042-6989&volume=38&spage=1525&epage=1535&date=1998&atitle=Regenerative+capacity+of+retinal+ganglion+cells+in+mammalsen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S0042-6989(97)00226-5en_HK
dc.identifier.pmid9667017-
dc.identifier.scopuseid_2-s2.0-0032077469en_HK
dc.identifier.hkuros36973en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032077469&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1525en_HK
dc.identifier.epage1535en_HK
dc.identifier.isiWOS:000073787400020-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK

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