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Article: Co-transplantation of Schwann cells promotes the survival and differentiation of neural stem cells transplanted into the injured spinal cord

TitleCo-transplantation of Schwann cells promotes the survival and differentiation of neural stem cells transplanted into the injured spinal cord
Authors
Issue Date2005
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DNE
Citation
Developmental Neuroscience, 2005, v. 27 n. 1, p. 20-26 How to Cite?
AbstractThe present study investigates whether Schwann cells (SCs) could promote the survival and differentiation of neural stem cells in the injured spinal cord. Neural stem cells were dissociated and cloned from the hippocampal tissue of newborn rats. SCs were also dissociated and purified simultaneously from the sciatic nerves of 4-day-old rats. The results showed that the number of surviving neural stem cells and differentiated neuron-like cells was significantly increased in the co-grafted (SCs and neural stem cells) group compared with the control group (neural stem cells only). Neuron-like cells that developed axon-like processes were observed more commonly in the co-grafted group. These results demonstrate that SCs can promote the survival and differentiation of transplanted neural stem cells in the injured spinal cord. Copyright © 2005 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/67976
ISSN
2015 Impact Factor: 2.898
2015 SCImago Journal Rankings: 1.484
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZeng, YSen_HK
dc.contributor.authorDing, Yen_HK
dc.contributor.authorWu, LZen_HK
dc.contributor.authorGuo, JSen_HK
dc.contributor.authorLi, HBen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorWu, WTen_HK
dc.date.accessioned2010-09-06T05:59:59Z-
dc.date.available2010-09-06T05:59:59Z-
dc.date.issued2005en_HK
dc.identifier.citationDevelopmental Neuroscience, 2005, v. 27 n. 1, p. 20-26en_HK
dc.identifier.issn0378-5866en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67976-
dc.description.abstractThe present study investigates whether Schwann cells (SCs) could promote the survival and differentiation of neural stem cells in the injured spinal cord. Neural stem cells were dissociated and cloned from the hippocampal tissue of newborn rats. SCs were also dissociated and purified simultaneously from the sciatic nerves of 4-day-old rats. The results showed that the number of surviving neural stem cells and differentiated neuron-like cells was significantly increased in the co-grafted (SCs and neural stem cells) group compared with the control group (neural stem cells only). Neuron-like cells that developed axon-like processes were observed more commonly in the co-grafted group. These results demonstrate that SCs can promote the survival and differentiation of transplanted neural stem cells in the injured spinal cord. Copyright © 2005 S. Karger AG.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DNEen_HK
dc.relation.ispartofDevelopmental Neuroscienceen_HK
dc.rightsDevelopmental Neuroscience. Copyright © S Karger AG.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshBiological Markers - metabolismen_HK
dc.subject.meshBrain Tissue Transplantation - methodsen_HK
dc.subject.meshCell Communication - physiologyen_HK
dc.subject.meshCell Differentiation - physiologyen_HK
dc.subject.meshCell Survival - physiologyen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshGraft Survival - physiologyen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshNerve Growth Factors - metabolism - secretionen_HK
dc.subject.meshNerve Tissue Proteins - metabolismen_HK
dc.subject.meshNeurons - physiologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSchwann Cells - metabolism - secretion - transplantationen_HK
dc.subject.meshSpinal Cord Injuries - therapyen_HK
dc.subject.meshStem Cell Transplantation - methodsen_HK
dc.titleCo-transplantation of Schwann cells promotes the survival and differentiation of neural stem cells transplanted into the injured spinal corden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-5866&volume=27&spage=20&epage=26&date=2005&atitle=Co-transplantation+of+Schwann+cells+promotes+the+survival+and+differentiation+of+neural+stem+cells+transplanted+into+the+injured+spinal+corden_HK
dc.identifier.emailWu, WT:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityWu, WT=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000084529en_HK
dc.identifier.pmid15886481-
dc.identifier.scopuseid_2-s2.0-18644367314en_HK
dc.identifier.hkuros104974en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18644367314&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue1en_HK
dc.identifier.spage20en_HK
dc.identifier.epage26en_HK
dc.identifier.isiWOS:000229034800003-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridZeng, YS=8236229300en_HK
dc.identifier.scopusauthoridDing, Y=26535640000en_HK
dc.identifier.scopusauthoridWu, LZ=7404903301en_HK
dc.identifier.scopusauthoridGuo, JS=7404488603en_HK
dc.identifier.scopusauthoridLi, HB=13008179800en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridWu, WT=7407081122en_HK

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