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Article: Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma

TitleCo-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma
Authors
KeywordsEpidermal growth factor receptor
Fibroblast growth factor 3
Nonsmall cell lung carcinoma
Tissue microarray
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2006, v. 106 n. 1, p. 146-155 How to Cite?
Abstract
BACKGROUND. Lung cancer is a prevalent cancer with a poor prognosis. To develop a useful in vitro cell model, a cell line of lung squamous cell carcinoma (SCC-35) was established. METHODS. The SCC-35 cell was characterized by comparative genomic hybridization (CGH) and spectral karyotyping (SKY). Chromosome microdissection, fluorescence in situ hybridization (FISH), and Southern and Northern blots analyses were used to study target genes. RESULTS. Two amplicons were found at chromosomes 7pl2 and 11q13. Amplification and overexpression of epidermal growth factor receptor (EGFR) at 7pl2 and fibroblast growth factor 3 (FGF3) at 11q13 were found. To understand the correlation between these two genes in nonsmall cell lung carcinoma (NSCLC) more comprehensively, overexpression of FGF3 and EGFR was investigated by immunohistochemistry with a tissue microarray containing 406 NSCLC samples. Cytoplasmic overexpression of FGF3 and EGFR was detected in 61% and 69% NSCLC cases, respectively. More interestingly, a significant correlation between overexpression of FGF3 and EGFR was found in NSCLC. CONCLUSION These results suggest that co-overexpression of FGF3 and EGFR may play an important role in the pathogenesis of lung carcinoma. © 2005 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/67967
ISSN
2013 Impact Factor: 4.901
ISI Accession Number ID
References

 

Author Affiliations
  1. Guangdong Provincial People's Hospital
  2. The University of Hong Kong
  3. Sun Yat-Sen University
DC FieldValueLanguage
dc.contributor.authorTai, ALSen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorFang, Yen_HK
dc.contributor.authorWu, YLen_HK
dc.contributor.authorHu, Len_HK
dc.contributor.authorDeng, Wen_HK
dc.contributor.authorTsao, GSWen_HK
dc.contributor.authorQiao, GBen_HK
dc.contributor.authorCheung, ALMen_HK
dc.contributor.authorGuan, KYen_HK
dc.date.accessioned2010-09-06T05:59:54Z-
dc.date.available2010-09-06T05:59:54Z-
dc.date.issued2006en_HK
dc.identifier.citationCancer, 2006, v. 106 n. 1, p. 146-155en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67967-
dc.description.abstractBACKGROUND. Lung cancer is a prevalent cancer with a poor prognosis. To develop a useful in vitro cell model, a cell line of lung squamous cell carcinoma (SCC-35) was established. METHODS. The SCC-35 cell was characterized by comparative genomic hybridization (CGH) and spectral karyotyping (SKY). Chromosome microdissection, fluorescence in situ hybridization (FISH), and Southern and Northern blots analyses were used to study target genes. RESULTS. Two amplicons were found at chromosomes 7pl2 and 11q13. Amplification and overexpression of epidermal growth factor receptor (EGFR) at 7pl2 and fibroblast growth factor 3 (FGF3) at 11q13 were found. To understand the correlation between these two genes in nonsmall cell lung carcinoma (NSCLC) more comprehensively, overexpression of FGF3 and EGFR was investigated by immunohistochemistry with a tissue microarray containing 406 NSCLC samples. Cytoplasmic overexpression of FGF3 and EGFR was detected in 61% and 69% NSCLC cases, respectively. More interestingly, a significant correlation between overexpression of FGF3 and EGFR was found in NSCLC. CONCLUSION These results suggest that co-overexpression of FGF3 and EGFR may play an important role in the pathogenesis of lung carcinoma. © 2005 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectEpidermal growth factor receptoren_HK
dc.subjectFibroblast growth factor 3en_HK
dc.subjectNonsmall cell lung carcinomaen_HK
dc.subjectTissue microarrayen_HK
dc.subject.meshCarcinoma, Non-Small-Cell Lung - genetics - metabolismen_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - metabolismen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshChromosomes, Human, Pair 11 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 7 - geneticsen_HK
dc.subject.meshFibroblast Growth Factor 3 - genetics - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLung Neoplasms - genetics - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshReceptor, Epidermal Growth Factor - genetics - metabolismen_HK
dc.subject.meshSpectral Karyotypingen_HK
dc.subject.meshTelomerase - genetics - metabolismen_HK
dc.subject.meshTissue Array Analysisen_HK
dc.titleCo-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=106&spage=146&epage=155&date=2006&atitle=Co-overexpression+of+fibroblast+growth+factor+3+and+epidermal+growth+factor+receptor+is+correlated+with+the+development+of+nonsmall+cell+lung+carcinomaen_HK
dc.identifier.emailDeng, W: wdeng@hkucc.hku.hken_HK
dc.identifier.emailTsao, GSW: gswtsao@hku.hken_HK
dc.identifier.emailCheung, ALM: lmcheung@hku.hken_HK
dc.identifier.authorityDeng, W=rp01640en_HK
dc.identifier.authorityTsao, GSW=rp00399en_HK
dc.identifier.authorityCheung, ALM=rp00332en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/cncr.21581en_HK
dc.identifier.pmid16329133en_HK
dc.identifier.scopuseid_2-s2.0-29744456389en_HK
dc.identifier.hkuros113129en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29744456389&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume106en_HK
dc.identifier.issue1en_HK
dc.identifier.spage146en_HK
dc.identifier.epage155en_HK
dc.identifier.isiWOS:000234358200019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTai, ALS=8234187900en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridFang, Y=7403457405en_HK
dc.identifier.scopusauthoridWu, YL=8974511600en_HK
dc.identifier.scopusauthoridHu, L=25958137600en_HK
dc.identifier.scopusauthoridDeng, W=7202223673en_HK
dc.identifier.scopusauthoridTsao, GSW=7102813116en_HK
dc.identifier.scopusauthoridQiao, GB=8318743700en_HK
dc.identifier.scopusauthoridCheung, ALM=7401806497en_HK
dc.identifier.scopusauthoridGuan, KY=10640471200en_HK
dc.identifier.citeulike493779-

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