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Article: Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma
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TitleCo-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma
 
AuthorsTai, ALS
Sham, JST
Xie, D3
Fang, Y3
Wu, YL1
Hu, L
Deng, W2
Tsao, GSW2
Qiao, GB1
Cheung, ALM2
Guan, KY2
 
KeywordsEpidermal growth factor receptor
Fibroblast growth factor 3
Nonsmall cell lung carcinoma
Tissue microarray
 
Issue Date2006
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
 
CitationCancer, 2006, v. 106 n. 1, p. 146-155 [How to Cite?]
DOI: http://dx.doi.org/10.1002/cncr.21581
 
AbstractBACKGROUND. Lung cancer is a prevalent cancer with a poor prognosis. To develop a useful in vitro cell model, a cell line of lung squamous cell carcinoma (SCC-35) was established. METHODS. The SCC-35 cell was characterized by comparative genomic hybridization (CGH) and spectral karyotyping (SKY). Chromosome microdissection, fluorescence in situ hybridization (FISH), and Southern and Northern blots analyses were used to study target genes. RESULTS. Two amplicons were found at chromosomes 7pl2 and 11q13. Amplification and overexpression of epidermal growth factor receptor (EGFR) at 7pl2 and fibroblast growth factor 3 (FGF3) at 11q13 were found. To understand the correlation between these two genes in nonsmall cell lung carcinoma (NSCLC) more comprehensively, overexpression of FGF3 and EGFR was investigated by immunohistochemistry with a tissue microarray containing 406 NSCLC samples. Cytoplasmic overexpression of FGF3 and EGFR was detected in 61% and 69% NSCLC cases, respectively. More interestingly, a significant correlation between overexpression of FGF3 and EGFR was found in NSCLC. CONCLUSION These results suggest that co-overexpression of FGF3 and EGFR may play an important role in the pathogenesis of lung carcinoma. © 2005 American Cancer Society.
 
ISSN0008-543X
2013 Impact Factor: 4.901
 
DOIhttp://dx.doi.org/10.1002/cncr.21581
 
ISI Accession Number IDWOS:000234358200019
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTai, ALS
 
dc.contributor.authorSham, JST
 
dc.contributor.authorXie, D
 
dc.contributor.authorFang, Y
 
dc.contributor.authorWu, YL
 
dc.contributor.authorHu, L
 
dc.contributor.authorDeng, W
 
dc.contributor.authorTsao, GSW
 
dc.contributor.authorQiao, GB
 
dc.contributor.authorCheung, ALM
 
dc.contributor.authorGuan, KY
 
dc.date.accessioned2010-09-06T05:59:54Z
 
dc.date.available2010-09-06T05:59:54Z
 
dc.date.issued2006
 
dc.description.abstractBACKGROUND. Lung cancer is a prevalent cancer with a poor prognosis. To develop a useful in vitro cell model, a cell line of lung squamous cell carcinoma (SCC-35) was established. METHODS. The SCC-35 cell was characterized by comparative genomic hybridization (CGH) and spectral karyotyping (SKY). Chromosome microdissection, fluorescence in situ hybridization (FISH), and Southern and Northern blots analyses were used to study target genes. RESULTS. Two amplicons were found at chromosomes 7pl2 and 11q13. Amplification and overexpression of epidermal growth factor receptor (EGFR) at 7pl2 and fibroblast growth factor 3 (FGF3) at 11q13 were found. To understand the correlation between these two genes in nonsmall cell lung carcinoma (NSCLC) more comprehensively, overexpression of FGF3 and EGFR was investigated by immunohistochemistry with a tissue microarray containing 406 NSCLC samples. Cytoplasmic overexpression of FGF3 and EGFR was detected in 61% and 69% NSCLC cases, respectively. More interestingly, a significant correlation between overexpression of FGF3 and EGFR was found in NSCLC. CONCLUSION These results suggest that co-overexpression of FGF3 and EGFR may play an important role in the pathogenesis of lung carcinoma. © 2005 American Cancer Society.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationCancer, 2006, v. 106 n. 1, p. 146-155 [How to Cite?]
DOI: http://dx.doi.org/10.1002/cncr.21581
 
dc.identifier.citeulike493779
 
dc.identifier.doihttp://dx.doi.org/10.1002/cncr.21581
 
dc.identifier.epage155
 
dc.identifier.hkuros113129
 
dc.identifier.isiWOS:000234358200019
 
dc.identifier.issn0008-543X
2013 Impact Factor: 4.901
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid16329133
 
dc.identifier.scopuseid_2-s2.0-29744456389
 
dc.identifier.spage146
 
dc.identifier.urihttp://hdl.handle.net/10722/67967
 
dc.identifier.volume106
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCancer
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.
 
dc.subject.meshCarcinoma, Non-Small-Cell Lung - genetics - metabolism
 
dc.subject.meshCarcinoma, Squamous Cell - genetics - metabolism
 
dc.subject.meshCell Line, Tumor
 
dc.subject.meshChromosomes, Human, Pair 11 - genetics
 
dc.subject.meshChromosomes, Human, Pair 7 - genetics
 
dc.subject.meshFibroblast Growth Factor 3 - genetics - metabolism
 
dc.subject.meshHumans
 
dc.subject.meshLung Neoplasms - genetics - metabolism
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshReceptor, Epidermal Growth Factor - genetics - metabolism
 
dc.subject.meshSpectral Karyotyping
 
dc.subject.meshTelomerase - genetics - metabolism
 
dc.subject.meshTissue Array Analysis
 
dc.subjectEpidermal growth factor receptor
 
dc.subjectFibroblast growth factor 3
 
dc.subjectNonsmall cell lung carcinoma
 
dc.subjectTissue microarray
 
dc.titleCo-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma
 
dc.typeArticle
 
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Author Affiliations
  1. Guangdong Provincial People's Hospital
  2. The University of Hong Kong
  3. Sun Yat-Sen University