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Article: Expression of c-jun in the lateral vestibular nucleus following spinal cord injury and peripheral nerve graft transplantation in adult rats

TitleExpression of c-jun in the lateral vestibular nucleus following spinal cord injury and peripheral nerve graft transplantation in adult rats
Authors
Issue Date2000
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-4864
Citation
Journal Of Neurocytology, 2000, v. 29 n. 2, p. 91-97 How to Cite?
AbstractThe time course of c-jun expression and the effect of a peripheral nerve (PN) graft on axonal regeneration and c-jun expression in the lateral vestibular nucleus (LVN) were investigated in this study. c-Jun was found in LVN neurons 1 day after hemisection of the spinal cord at C3, with weak immunoreactivity. Strong c-Jun positive immunoreactivity was found 3 days post-injury. The expression of c-jun reached its maximum level (45% ± 2.5, mean ± SD) 1 week post-injury and gradually decreased to about a third of its peak value 6 weeks after the inflicted lesion. The PN graft implanted at the lesion site significantly enhanced the number of neurons expressing c-jun 4 weeks after PN transplantation (from 20% of LVN neurons in axotomy alone to 30% in PN graft transplantation, P < 0.05). The PN graft induced injured neurons to regrow into the PN graft. About 91 FG-labeled neurons were found in the LVN and approximately 87% of these neurons showed c-Jun positive immunoreactivity. The high percentage of regenerating neurons expressing c-jun suggested that c-Jun might be involved in the regenerative process. The result of double staining for c-Jun and NOS showed that approximately 93% NOS positive neurons co-expressed c-Jun. Comparing the time course of the appearance of c-Jun with that of NOS, the expression of c-jun preceded that of NOS. Although a high percentage of NOS reactive neurons expressed c-jun, the expression of NOS in damaged LVN neurons needs to be further investigated.
Persistent Identifierhttp://hdl.handle.net/10722/67938
ISSN
2007 Impact Factor: 1.935
2009 SCImago Journal Rankings: 0.911
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, Yen_HK
dc.contributor.authorTay, Den_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-09-06T05:59:38Z-
dc.date.available2010-09-06T05:59:38Z-
dc.date.issued2000en_HK
dc.identifier.citationJournal Of Neurocytology, 2000, v. 29 n. 2, p. 91-97en_HK
dc.identifier.issn0300-4864en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67938-
dc.description.abstractThe time course of c-jun expression and the effect of a peripheral nerve (PN) graft on axonal regeneration and c-jun expression in the lateral vestibular nucleus (LVN) were investigated in this study. c-Jun was found in LVN neurons 1 day after hemisection of the spinal cord at C3, with weak immunoreactivity. Strong c-Jun positive immunoreactivity was found 3 days post-injury. The expression of c-jun reached its maximum level (45% ± 2.5, mean ± SD) 1 week post-injury and gradually decreased to about a third of its peak value 6 weeks after the inflicted lesion. The PN graft implanted at the lesion site significantly enhanced the number of neurons expressing c-jun 4 weeks after PN transplantation (from 20% of LVN neurons in axotomy alone to 30% in PN graft transplantation, P < 0.05). The PN graft induced injured neurons to regrow into the PN graft. About 91 FG-labeled neurons were found in the LVN and approximately 87% of these neurons showed c-Jun positive immunoreactivity. The high percentage of regenerating neurons expressing c-jun suggested that c-Jun might be involved in the regenerative process. The result of double staining for c-Jun and NOS showed that approximately 93% NOS positive neurons co-expressed c-Jun. Comparing the time course of the appearance of c-Jun with that of NOS, the expression of c-jun preceded that of NOS. Although a high percentage of NOS reactive neurons expressed c-jun, the expression of NOS in damaged LVN neurons needs to be further investigated.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-4864en_HK
dc.relation.ispartofJournal of Neurocytologyen_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshNerve Regeneration - physiologyen_HK
dc.subject.meshNeurons - chemistry - enzymologyen_HK
dc.subject.meshNitric Oxide Synthase - analysis - biosynthesisen_HK
dc.subject.meshProto-Oncogene Proteins c-jun - analysis - biosynthesisen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSpinal Cord Injuries - metabolism - surgeryen_HK
dc.subject.meshTibial Nerve - transplantationen_HK
dc.subject.meshVestibular Nucleus, Lateral - chemistry - cytology - metabolismen_HK
dc.titleExpression of c-jun in the lateral vestibular nucleus following spinal cord injury and peripheral nerve graft transplantation in adult ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-4864&volume=29&issue=2&spage=91&epage=97&date=2000&atitle=Expression+of+c-jun+in+the+lateral+vestibular+nucleus+following+spinal+cord+injury+and+peripheral+nerve+graft+transplantation+in+adult+ratsen_HK
dc.identifier.emailTay, D:dkctay@hkucc.hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityTay, D=rp00336en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/A:1007100411643en_HK
dc.identifier.pmid11068337-
dc.identifier.scopuseid_2-s2.0-0033669065en_HK
dc.identifier.hkuros51529en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033669065&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue2en_HK
dc.identifier.spage91en_HK
dc.identifier.epage97en_HK
dc.identifier.isiWOS:000165156200002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJin, Y=37109806000en_HK
dc.identifier.scopusauthoridTay, D=7006796825en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK

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