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Article: Survival of injured spinal motoneurons in adult rat upon treatment with glial cell line-derived neurotrophic factor at 2 weeks but not at 4 weeks after root avulsion

TitleSurvival of injured spinal motoneurons in adult rat upon treatment with glial cell line-derived neurotrophic factor at 2 weeks but not at 4 weeks after root avulsion
Authors
Issue Date2006
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neu
Citation
Journal Of Neurotrauma, 2006, v. 23 n. 6, p. 920-927 How to Cite?
AbstractWe conducted a study of whether treatment with glial cell line-derived neurotrophic factor (GDNF) initiated at 2 or 4 weeks after spinal-root avulsion could promote survival and regulate neuronal nitric oxide synthase (nNOS) expression in adult rat spinal motoneurons. By 6 weeks after root avulsion, the treatment given at 2 weeks not only increased motoneuron survival (86.1% vs. 27.9%), but also reversed the atrophy of injured motoneurons and increased their somatic size (101.3% vs. 52.9%) in comparison to the untreated control group of animals. All surviving motoneurons in the GDNF-treated group showed immunoreactivity for choline acetyltransferase. In contrast, GDNF treatment at 4 weeks post-injury failed to promote motoneuron survival (33.1% vs. 27.9%) at 6 weeks compared to the control group. Both the 2- and 4-week post-injury treatments downregulated nNOS expression. This finding suggests that injured adult motoneurons die shortly (a few weeks in the rat) after root avulsion injury, but can be saved from degeneration by treatment within the proper time frame after injury, which in the case of GDNF treatment in rats, appears to be within 2 weeks of the avulsion injury of the spinal root. These findings provide useful information for choosing the best time frame for the potential clinical treatment of brachial plexus avulsion. © Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/67937
ISSN
2015 Impact Factor: 4.377
2015 SCImago Journal Rankings: 1.945
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, LHen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-09-06T05:59:37Z-
dc.date.available2010-09-06T05:59:37Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Neurotrauma, 2006, v. 23 n. 6, p. 920-927en_HK
dc.identifier.issn0897-7151en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67937-
dc.description.abstractWe conducted a study of whether treatment with glial cell line-derived neurotrophic factor (GDNF) initiated at 2 or 4 weeks after spinal-root avulsion could promote survival and regulate neuronal nitric oxide synthase (nNOS) expression in adult rat spinal motoneurons. By 6 weeks after root avulsion, the treatment given at 2 weeks not only increased motoneuron survival (86.1% vs. 27.9%), but also reversed the atrophy of injured motoneurons and increased their somatic size (101.3% vs. 52.9%) in comparison to the untreated control group of animals. All surviving motoneurons in the GDNF-treated group showed immunoreactivity for choline acetyltransferase. In contrast, GDNF treatment at 4 weeks post-injury failed to promote motoneuron survival (33.1% vs. 27.9%) at 6 weeks compared to the control group. Both the 2- and 4-week post-injury treatments downregulated nNOS expression. This finding suggests that injured adult motoneurons die shortly (a few weeks in the rat) after root avulsion injury, but can be saved from degeneration by treatment within the proper time frame after injury, which in the case of GDNF treatment in rats, appears to be within 2 weeks of the avulsion injury of the spinal root. These findings provide useful information for choosing the best time frame for the potential clinical treatment of brachial plexus avulsion. © Mary Ann Liebert, Inc.en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neuen_HK
dc.relation.ispartofJournal of Neurotraumaen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Survival - physiologyen_HK
dc.subject.meshCholine O-Acetyltransferase - metabolismen_HK
dc.subject.meshDown-Regulation - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlial Cell Line-Derived Neurotrophic Factor - pharmacologyen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMotor Neurons - enzymology - pathologyen_HK
dc.subject.meshNerve Degeneration - prevention & controlen_HK
dc.subject.meshNitric Oxide Synthase Type I - metabolismen_HK
dc.subject.meshRadiculopathy - enzymology - pathologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSpinal Cord Injuries - drug therapy - enzymology - pathologyen_HK
dc.subject.meshSpinal Nerve Roots - enzymology - pathologyen_HK
dc.titleSurvival of injured spinal motoneurons in adult rat upon treatment with glial cell line-derived neurotrophic factor at 2 weeks but not at 4 weeks after root avulsionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0897-7151&volume=23&spage=920&epage=927&date=2006&atitle=Survival+of+injured+spinal+motoneurons+in+adult+rat+upon+treatment+with+glial+cell+line-derived+neurotrophic+factor+at+2+weeks+but+not+at+4+weeks+after+root+avulsionen_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1089/neu.2006.23.920en_HK
dc.identifier.pmid16774476-
dc.identifier.scopuseid_2-s2.0-33745493777en_HK
dc.identifier.hkuros121324en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745493777&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue6en_HK
dc.identifier.spage920en_HK
dc.identifier.epage927en_HK
dc.identifier.isiWOS:000238549000008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhou, LH=7404125592en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK

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