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Article: The growth arrest specific gene (gas6) protein is expressed in abnormal embryos sired by male golden hamsters with accessory sex glands removed

TitleThe growth arrest specific gene (gas6) protein is expressed in abnormal embryos sired by male golden hamsters with accessory sex glands removed
Authors
Issue Date2001
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00429/index.htm
Citation
Anatomy and Embryology, 2001, v. 203, p. 343-355 How to Cite?
AbstractExpression of growth arrest specific gene (gas6) and its receptors in embryonic and uterine tissues in normal pregnancy and pregnancy that produces abnormal embryos sired by hamsters with partial or total deletion of male accessory sex glands was studied by in situ hybridization, immunohistochemistry, reverse-transcription polymerization reaction and enzyme-linked immunoabsorbant assay. At oestrus, very strong gas6 mRNA and Gas6 expression were seen only in the uterine epithelium and endometrial glands. Upon implantation, both of them could be demonstrated in the decidualizing stroma. From day 4 to day 7 p.c, gas6 mRNA was present in the embryo, but Gas6 immunoreactivity was only found in those showing features of degeneration. The gas6:β-actin mRNA ratio was low in oestrus and at day 4 of pregnancy but rose as the embryo grew. As for the receptors, Rse was detected in embryonic cells during days 5–7 p.c., and decidual cell from days 4 to 7 p.c., but Mer could be found in decidual cells and trophoblasts. It was concluded that gas6 had a role in endometrial transformation during decidualization and trophoblastic invasion. In the embryo, gas6 was transcribed, but the protein was only produced in response to need, such as when normal progression of development was threatened.
Persistent Identifierhttp://hdl.handle.net/10722/67932
ISSN
2008 Impact Factor: 1.39
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJiang, HYen_HK
dc.contributor.authorLee, KHen_HK
dc.contributor.authorSchneider, Cen_HK
dc.contributor.authorO, WSen_HK
dc.contributor.authorTang, PLen_HK
dc.contributor.authorChow, PHen_HK
dc.date.accessioned2010-09-06T05:59:35Z-
dc.date.available2010-09-06T05:59:35Z-
dc.date.issued2001en_HK
dc.identifier.citationAnatomy and Embryology, 2001, v. 203, p. 343-355en_HK
dc.identifier.issn0340-2061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67932-
dc.description.abstractExpression of growth arrest specific gene (gas6) and its receptors in embryonic and uterine tissues in normal pregnancy and pregnancy that produces abnormal embryos sired by hamsters with partial or total deletion of male accessory sex glands was studied by in situ hybridization, immunohistochemistry, reverse-transcription polymerization reaction and enzyme-linked immunoabsorbant assay. At oestrus, very strong gas6 mRNA and Gas6 expression were seen only in the uterine epithelium and endometrial glands. Upon implantation, both of them could be demonstrated in the decidualizing stroma. From day 4 to day 7 p.c, gas6 mRNA was present in the embryo, but Gas6 immunoreactivity was only found in those showing features of degeneration. The gas6:β-actin mRNA ratio was low in oestrus and at day 4 of pregnancy but rose as the embryo grew. As for the receptors, Rse was detected in embryonic cells during days 5–7 p.c., and decidual cell from days 4 to 7 p.c., but Mer could be found in decidual cells and trophoblasts. It was concluded that gas6 had a role in endometrial transformation during decidualization and trophoblastic invasion. In the embryo, gas6 was transcribed, but the protein was only produced in response to need, such as when normal progression of development was threatened.-
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00429/index.htmen_HK
dc.relation.ispartofAnatomy and Embryologyen_HK
dc.titleThe growth arrest specific gene (gas6) protein is expressed in abnormal embryos sired by male golden hamsters with accessory sex glands removeden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0340-2061&volume=203&spage=343&epage=355&date=2001&atitle=The+growth+arrest+specific+gene+(gas6)+protein+is+expressed+in+abnormal+embryos+sired+by+male+golden+hamsters+with+accessory+sex+glands+removeden_HK
dc.identifier.emailO, WS: owaisum@hkucc.hku.hken_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s004290100159-
dc.identifier.pmid11411309-
dc.identifier.scopuseid_2-s2.0-0035017855-
dc.identifier.hkuros59548en_HK
dc.identifier.isiWOS:000169033300003-

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