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Article: Id-1 expression and cell survival

TitleId-1 expression and cell survival
Authors
Issue Date2004
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1360-8185
Citation
Apoptosis, 2004, v. 9 n. 3, p. 279-289 How to Cite?
AbstractThe Id (inhibitor of differentiation or DNA binding) helix-loop-helix (HLH) proteins are a group of dominant negative regulators of basic HLH transcriptional factors which promote cell differentiation. Recent evidence has revealed that Id proteins, especially Id-1, are also able to promote cell proliferation and cell cycle progression through inactivation of tumour suppressor and activation of growth promoting pathways in mammalian cells. In addition, upregulation of Id-1 has been found in many types of human cancer and its expression levels are also associated with advanced tumour stage. Furthermore, ectopic expression of Id-1 in human cancer cells is able to induce cell proliferation under sub-optimal conditions and protect the cells against apoptosis. These lines of evidence strongly indicate Id-1 as a positive regulator of cell growth and its expression may be a key factor required for tumour cell proliferation. This review will discuss recent evidence on the role of Id-1 in cell proliferation and survival, and its significance in malignant transformation. In addition, we will highlight the recent development in the understanding of the molecular mechanisms responsible for the action of Id-1 in promoting cell survival and tumourigenesis. Finally, the therapeutic implications through inactivation of Id-1 in the treatment of human cancer will also be addressed.
Persistent Identifierhttp://hdl.handle.net/10722/67930
ISSN
2015 Impact Factor: 3.592
2015 SCImago Journal Rankings: 1.554
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorLing, MTen_HK
dc.date.accessioned2010-09-06T05:59:34Z-
dc.date.available2010-09-06T05:59:34Z-
dc.date.issued2004en_HK
dc.identifier.citationApoptosis, 2004, v. 9 n. 3, p. 279-289en_HK
dc.identifier.issn1360-8185en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67930-
dc.description.abstractThe Id (inhibitor of differentiation or DNA binding) helix-loop-helix (HLH) proteins are a group of dominant negative regulators of basic HLH transcriptional factors which promote cell differentiation. Recent evidence has revealed that Id proteins, especially Id-1, are also able to promote cell proliferation and cell cycle progression through inactivation of tumour suppressor and activation of growth promoting pathways in mammalian cells. In addition, upregulation of Id-1 has been found in many types of human cancer and its expression levels are also associated with advanced tumour stage. Furthermore, ectopic expression of Id-1 in human cancer cells is able to induce cell proliferation under sub-optimal conditions and protect the cells against apoptosis. These lines of evidence strongly indicate Id-1 as a positive regulator of cell growth and its expression may be a key factor required for tumour cell proliferation. This review will discuss recent evidence on the role of Id-1 in cell proliferation and survival, and its significance in malignant transformation. In addition, we will highlight the recent development in the understanding of the molecular mechanisms responsible for the action of Id-1 in promoting cell survival and tumourigenesis. Finally, the therapeutic implications through inactivation of Id-1 in the treatment of human cancer will also be addressed.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1360-8185en_HK
dc.relation.ispartofApoptosisen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshCell Cycleen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshCell Physiological Phenomenaen_HK
dc.subject.meshCell Survivalen_HK
dc.subject.meshCell Transformation, Neoplasticen_HK
dc.subject.meshDNA-Binding Proteins - genetics - metabolismen_HK
dc.subject.meshHelix-Loop-Helix Motifsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInhibitor of Differentiation Protein 1en_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshRepressor Proteins - chemistry - metabolismen_HK
dc.subject.meshTranscription Factors - chemistry - genetics - metabolismen_HK
dc.subject.meshUp-Regulationen_HK
dc.titleId-1 expression and cell survivalen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1360-8185&volume=9 No 3&spage=279&epage=289&date=2004&atitle=Id-1+expression+and+cell+survivalen_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.emailLing, MT:patling@hkucc.hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.identifier.authorityLing, MT=rp00449en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/B:APPT.0000025804.25396.79en_HK
dc.identifier.pmid15258459-
dc.identifier.scopuseid_2-s2.0-3242768383en_HK
dc.identifier.hkuros95175en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3242768383&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue3en_HK
dc.identifier.spage279en_HK
dc.identifier.epage289en_HK
dc.identifier.isiWOS:000221102700003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridWang, X=23053054900en_HK
dc.identifier.scopusauthoridLing, MT=7102229780en_HK

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