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Article: Differential activation of c-fos immunoreactivity after hypophysectomy in developing and adult rats
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TitleDifferential activation of c-fos immunoreactivity after hypophysectomy in developing and adult rats
 
AuthorsYuan, Q1
Scott, DE2
So, KF1
Wu, W1 1
 
Issue Date2007
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/113463905
 
CitationAnatomical Record, 2007, v. 290 n. 9, p. 1050-1056 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ar.20570
 
AbstractThe aim of the present study is to compare c-fos expression in identified hypothalamic vasopressin (AVP) and oxytocin (OT) neurons in developing (PN7 and PN14) and adult rats following hypophysectomy using dual-labeled immunostaining. Our results showed that hypophysectomy induced c-fos expression in supraoptic (SON) and paraventricular (PVN) nuclei in both the developing and adult rats. Few or no positive cells were observed in the same nuclei in sham-operated animals. Quantitative analysis for c-fos and either of the above named neuropeptides revealed that almost all AVP and OT neurons in the adult and PN14 groups expressed c-fos in response to hypophysectomy. In PN7, hypophysectomy also induced all AVP neurons to express c-fos in SON and PVN. However, few OT neurons in the SON and PVN produced c-fos after hypophysectomy. In addition, the time course of c-fos expression was different in the developing and adult rats after hypophysectomy. The c-fos expression in the developing rats exhibited a more prolonged induction in which staining for c-fos persisted for at least 3 days after hypophysectomy compared with that in the adult in which c-fos immunoreactivity disappeared within 24 hr post-lesion. This study demonstrates that c-fos expression after hypophysectomy is regulated differently during development. © 2007 Wiley-Liss, Inc.
 
ISSN1932-8486
2012 Impact Factor: 1.343
2012 SCImago Journal Rankings: 0.540
 
DOIhttp://dx.doi.org/10.1002/ar.20570
 
ISI Accession Number IDWOS:000249025800003
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYuan, Q
 
dc.contributor.authorScott, DE
 
dc.contributor.authorSo, KF
 
dc.contributor.authorWu, W
 
dc.date.accessioned2010-09-06T05:59:23Z
 
dc.date.available2010-09-06T05:59:23Z
 
dc.date.issued2007
 
dc.description.abstractThe aim of the present study is to compare c-fos expression in identified hypothalamic vasopressin (AVP) and oxytocin (OT) neurons in developing (PN7 and PN14) and adult rats following hypophysectomy using dual-labeled immunostaining. Our results showed that hypophysectomy induced c-fos expression in supraoptic (SON) and paraventricular (PVN) nuclei in both the developing and adult rats. Few or no positive cells were observed in the same nuclei in sham-operated animals. Quantitative analysis for c-fos and either of the above named neuropeptides revealed that almost all AVP and OT neurons in the adult and PN14 groups expressed c-fos in response to hypophysectomy. In PN7, hypophysectomy also induced all AVP neurons to express c-fos in SON and PVN. However, few OT neurons in the SON and PVN produced c-fos after hypophysectomy. In addition, the time course of c-fos expression was different in the developing and adult rats after hypophysectomy. The c-fos expression in the developing rats exhibited a more prolonged induction in which staining for c-fos persisted for at least 3 days after hypophysectomy compared with that in the adult in which c-fos immunoreactivity disappeared within 24 hr post-lesion. This study demonstrates that c-fos expression after hypophysectomy is regulated differently during development. © 2007 Wiley-Liss, Inc.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationAnatomical Record, 2007, v. 290 n. 9, p. 1050-1056 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ar.20570
 
dc.identifier.doihttp://dx.doi.org/10.1002/ar.20570
 
dc.identifier.epage1056
 
dc.identifier.hkuros137852
 
dc.identifier.isiWOS:000249025800003
 
dc.identifier.issn1932-8486
2012 Impact Factor: 1.343
2012 SCImago Journal Rankings: 0.540
 
dc.identifier.issue9
 
dc.identifier.openurl
 
dc.identifier.pmid17661378
 
dc.identifier.scopuseid_2-s2.0-34748821811
 
dc.identifier.spage1050
 
dc.identifier.urihttp://hdl.handle.net/10722/67911
 
dc.identifier.volume290
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/113463905
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAnatomical Record
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe Anatomical Record. Copyright © John Wiley & Sons, Inc.
 
dc.subject.meshAging - metabolism
 
dc.subject.meshAnimals
 
dc.subject.meshHypophysectomy
 
dc.subject.meshImmunohistochemistry
 
dc.subject.meshMale
 
dc.subject.meshMicroscopy, Confocal
 
dc.subject.meshNeurons - metabolism
 
dc.subject.meshOxytocin - metabolism
 
dc.subject.meshParaventricular Hypothalamic Nucleus - cytology - metabolism
 
dc.subject.meshProto-Oncogene Proteins c-fos - metabolism
 
dc.subject.meshRats
 
dc.subject.meshRats, Sprague-Dawley
 
dc.subject.meshSupraoptic Nucleus - cytology - metabolism
 
dc.subject.meshTime Factors
 
dc.subject.meshUp-Regulation
 
dc.subject.meshVasopressins - metabolism
 
dc.titleDifferential activation of c-fos immunoreactivity after hypophysectomy in developing and adult rats
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Eastern Virginia Medical School