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Article: Differential activation of c-fos immunoreactivity after hypophysectomy in developing and adult rats

TitleDifferential activation of c-fos immunoreactivity after hypophysectomy in developing and adult rats
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/113463905
Citation
Anatomical Record, 2007, v. 290 n. 9, p. 1050-1056 How to Cite?
AbstractThe aim of the present study is to compare c-fos expression in identified hypothalamic vasopressin (AVP) and oxytocin (OT) neurons in developing (PN7 and PN14) and adult rats following hypophysectomy using dual-labeled immunostaining. Our results showed that hypophysectomy induced c-fos expression in supraoptic (SON) and paraventricular (PVN) nuclei in both the developing and adult rats. Few or no positive cells were observed in the same nuclei in sham-operated animals. Quantitative analysis for c-fos and either of the above named neuropeptides revealed that almost all AVP and OT neurons in the adult and PN14 groups expressed c-fos in response to hypophysectomy. In PN7, hypophysectomy also induced all AVP neurons to express c-fos in SON and PVN. However, few OT neurons in the SON and PVN produced c-fos after hypophysectomy. In addition, the time course of c-fos expression was different in the developing and adult rats after hypophysectomy. The c-fos expression in the developing rats exhibited a more prolonged induction in which staining for c-fos persisted for at least 3 days after hypophysectomy compared with that in the adult in which c-fos immunoreactivity disappeared within 24 hr post-lesion. This study demonstrates that c-fos expression after hypophysectomy is regulated differently during development. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/67911
ISSN
2014 Impact Factor: 1.542
2014 SCImago Journal Rankings: 0.636
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Qen_HK
dc.contributor.authorScott, DEen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-09-06T05:59:23Z-
dc.date.available2010-09-06T05:59:23Z-
dc.date.issued2007en_HK
dc.identifier.citationAnatomical Record, 2007, v. 290 n. 9, p. 1050-1056en_HK
dc.identifier.issn1932-8486en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67911-
dc.description.abstractThe aim of the present study is to compare c-fos expression in identified hypothalamic vasopressin (AVP) and oxytocin (OT) neurons in developing (PN7 and PN14) and adult rats following hypophysectomy using dual-labeled immunostaining. Our results showed that hypophysectomy induced c-fos expression in supraoptic (SON) and paraventricular (PVN) nuclei in both the developing and adult rats. Few or no positive cells were observed in the same nuclei in sham-operated animals. Quantitative analysis for c-fos and either of the above named neuropeptides revealed that almost all AVP and OT neurons in the adult and PN14 groups expressed c-fos in response to hypophysectomy. In PN7, hypophysectomy also induced all AVP neurons to express c-fos in SON and PVN. However, few OT neurons in the SON and PVN produced c-fos after hypophysectomy. In addition, the time course of c-fos expression was different in the developing and adult rats after hypophysectomy. The c-fos expression in the developing rats exhibited a more prolonged induction in which staining for c-fos persisted for at least 3 days after hypophysectomy compared with that in the adult in which c-fos immunoreactivity disappeared within 24 hr post-lesion. This study demonstrates that c-fos expression after hypophysectomy is regulated differently during development. © 2007 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/113463905en_HK
dc.relation.ispartofAnatomical Recorden_HK
dc.rightsThe Anatomical Record. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAging - metabolismen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshHypophysectomyen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicroscopy, Confocalen_HK
dc.subject.meshNeurons - metabolismen_HK
dc.subject.meshOxytocin - metabolismen_HK
dc.subject.meshParaventricular Hypothalamic Nucleus - cytology - metabolismen_HK
dc.subject.meshProto-Oncogene Proteins c-fos - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSupraoptic Nucleus - cytology - metabolismen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshUp-Regulationen_HK
dc.subject.meshVasopressins - metabolismen_HK
dc.titleDifferential activation of c-fos immunoreactivity after hypophysectomy in developing and adult ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1932-8486&volume=290&spage=1050&epage=1056&date=2007&atitle=Differential+activation+of+c-fos+immunoreactivity+after+hypophysectomy+in+developing+and+adult+ratsen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/ar.20570en_HK
dc.identifier.pmid17661378en_HK
dc.identifier.scopuseid_2-s2.0-34748821811en_HK
dc.identifier.hkuros137852en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34748821811&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume290en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1050en_HK
dc.identifier.epage1056en_HK
dc.identifier.isiWOS:000249025800003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuan, Q=7202814773en_HK
dc.identifier.scopusauthoridScott, DE=7404951677en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK

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