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Article: Exhaled and sputum nitric oxide in bronchiectasis: Correlation with clinical parameters

TitleExhaled and sputum nitric oxide in bronchiectasis: Correlation with clinical parameters
Authors
Issue Date2002
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 2002, v. 121 n. 1, p. 88-94 How to Cite?
AbstractStudy objectives: Although there has been tremendous attention on endogenous nitric oxide (NO) production in many respiratory and systemic diseases, little is known on NO production in bronchiectasis. Design and setting: We determined exhaled and sputum NO levels in 109 patients with stable bronchiectasis (71 women; mean ± SD age, 58.2 ± 14.1 years) and 78 control subjects (39 women; mean age, 56.7 ± 12.1 years) by using an automatic chemiluminescence analyzer. Measurements and results: There was no significant difference in exhaled NO between patients with bronchiectasis and control subjects (p = 0.11). Bronchiectasis patients with Pseudomonas aeruginosa infection had a significantly lower exhaled, but not sputum, NO levels than their counterparts and control subjects (p = 0.04 and p = 0.009, respectively). Exhaled NO correlated with 24-h sputum volume in P aeruginosa-infected patients (r = - 0.36; p = 0.002). After adjustment for sputum volume and number of bronchiectatic lung lobes, P aeruginosa-infected patients still had lower exhaled NO levels than their counterparts (p = 0.01). There was no correlation between exhaled NO with FEV1, FVC, and the number of bronchiectatic lung lobes (p > 0.05). Sputum NO levels were not different between patients and control subjects (p = 0.64), and had no correlation with clinical parameters. Conclusion: Exhaled NO appears to be reduced among bronchiectasis patients with P aeruginosa infection independent of other clinical parameters, and further studies on the potential mechanisms and pathogenetic implications of this reduction should be pursued.
Persistent Identifierhttp://hdl.handle.net/10722/67902
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, KWen_HK
dc.contributor.authorLeung, Ren_HK
dc.contributor.authorFung, PCWen_HK
dc.contributor.authorChan, SLen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorLam, WKen_HK
dc.date.accessioned2010-09-06T05:59:18Z-
dc.date.available2010-09-06T05:59:18Z-
dc.date.issued2002en_HK
dc.identifier.citationChest, 2002, v. 121 n. 1, p. 88-94en_HK
dc.identifier.issn0012-3692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67902-
dc.description.abstractStudy objectives: Although there has been tremendous attention on endogenous nitric oxide (NO) production in many respiratory and systemic diseases, little is known on NO production in bronchiectasis. Design and setting: We determined exhaled and sputum NO levels in 109 patients with stable bronchiectasis (71 women; mean ± SD age, 58.2 ± 14.1 years) and 78 control subjects (39 women; mean age, 56.7 ± 12.1 years) by using an automatic chemiluminescence analyzer. Measurements and results: There was no significant difference in exhaled NO between patients with bronchiectasis and control subjects (p = 0.11). Bronchiectasis patients with Pseudomonas aeruginosa infection had a significantly lower exhaled, but not sputum, NO levels than their counterparts and control subjects (p = 0.04 and p = 0.009, respectively). Exhaled NO correlated with 24-h sputum volume in P aeruginosa-infected patients (r = - 0.36; p = 0.002). After adjustment for sputum volume and number of bronchiectatic lung lobes, P aeruginosa-infected patients still had lower exhaled NO levels than their counterparts (p = 0.01). There was no correlation between exhaled NO with FEV1, FVC, and the number of bronchiectatic lung lobes (p > 0.05). Sputum NO levels were not different between patients and control subjects (p = 0.64), and had no correlation with clinical parameters. Conclusion: Exhaled NO appears to be reduced among bronchiectasis patients with P aeruginosa infection independent of other clinical parameters, and further studies on the potential mechanisms and pathogenetic implications of this reduction should be pursued.en_HK
dc.languageengen_HK
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_HK
dc.relation.ispartofChesten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBreath Testsen_HK
dc.subject.meshBronchiectasis - diagnosisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshForced Expiratory Volume - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNitric Oxide - analysisen_HK
dc.subject.meshPneumonia, Bacterial - diagnosisen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshPseudomonas Infections - diagnosisen_HK
dc.subject.meshPseudomonas aeruginosaen_HK
dc.subject.meshSputum - chemistryen_HK
dc.subject.meshVital Capacity - physiologyen_HK
dc.titleExhaled and sputum nitric oxide in bronchiectasis: Correlation with clinical parametersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-3692&volume=121&issue=1&spage=88&epage=94&date=2002&atitle=Exhaled+and+sputum+nitric+oxide+in+bronchiectasis:+correlation+with+clinical+parametersen_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1378/chest.121.1.88en_HK
dc.identifier.pmid11796436-
dc.identifier.scopuseid_2-s2.0-0036155518en_HK
dc.identifier.hkuros67775en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036155518&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume121en_HK
dc.identifier.issue1en_HK
dc.identifier.spage88en_HK
dc.identifier.epage94en_HK
dc.identifier.isiWOS:000173431400018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsang, KW=7201555024en_HK
dc.identifier.scopusauthoridLeung, R=7101876102en_HK
dc.identifier.scopusauthoridFung, PCW=7101613315en_HK
dc.identifier.scopusauthoridChan, SL=14055434000en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK

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