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Conference Paper: Protein kinases as technological platforms to screen neuroprotective agents from chinese medicine

TitleProtein kinases as technological platforms to screen neuroprotective agents from chinese medicine
Authors
Issue Date2006
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
The 24th Annual Scientific Meeting of the Hong Kong Society of Neuroscience, Hong Kong, 13-14 January, 2005. In Neurosignals, 2006, v. 15 n. 3, p. 133, abstract no. P-36/24 How to Cite?
AbstractAlzheimer’s disease (AD) is an age-associated neurodegenerative disorder affecting quite a lot of elderly in different countries. Current treatment for AD depends on cholinesterase inhibitor. However, its effectiveness is quite disappointing. Therefore, there is an urgent need to search for alternate treatment and neuroprotection is a possible strategy. One of the critical pathological factors in AD is the accumulation of beta-amyloid (A ) peptides found in the cortex of AD brain. A peptides have been shown to induce cell death in cultured neurons and are often used as a model toxin to study the pathogenesis of AD. Previous studies have shown that stress kinases (such as PKR, JNK, p38 MAPK and GSK3 ) mediate A -triggered neuronal apoptosis. On the other hand, both kinases PDK-1 and Akt in survival signaling pathway can inhibit apoptosis. It is hypothesized that neuroprotection can be achieved by inhibition on pro-apoptotic pathways or activation of survival pathways. By western blot analysis, we found that polysaccharides from Nerium indicum (Oleander) activate the PDK-1- Akt survival signaling pathway while the extract from Lycium barbarum (Gou-Qi-Zi) inhibits A -triggered PKR and JNK phosphorylation. All these extracts can protect neurons against A toxicity by inhibition on caspase-3 activity. In conclusion, it is possible to make use of protein kinases to screen potential neuroprotective agents from Chinese medicine. Acknowledgement: This work is supported by Area of Excellence (AoE/P-10/01).
Persistent Identifierhttp://hdl.handle.net/10722/67901
ISSN
2015 Impact Factor: 1.593
2015 SCImago Journal Rankings: 0.763

 

DC FieldValueLanguage
dc.contributor.authorYu, MSen_HK
dc.contributor.authorLai, SWen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-06T05:59:18Z-
dc.date.available2010-09-06T05:59:18Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 24th Annual Scientific Meeting of the Hong Kong Society of Neuroscience, Hong Kong, 13-14 January, 2005. In Neurosignals, 2006, v. 15 n. 3, p. 133, abstract no. P-36/24en_HK
dc.identifier.issn1424-862Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67901-
dc.description.abstractAlzheimer’s disease (AD) is an age-associated neurodegenerative disorder affecting quite a lot of elderly in different countries. Current treatment for AD depends on cholinesterase inhibitor. However, its effectiveness is quite disappointing. Therefore, there is an urgent need to search for alternate treatment and neuroprotection is a possible strategy. One of the critical pathological factors in AD is the accumulation of beta-amyloid (A ) peptides found in the cortex of AD brain. A peptides have been shown to induce cell death in cultured neurons and are often used as a model toxin to study the pathogenesis of AD. Previous studies have shown that stress kinases (such as PKR, JNK, p38 MAPK and GSK3 ) mediate A -triggered neuronal apoptosis. On the other hand, both kinases PDK-1 and Akt in survival signaling pathway can inhibit apoptosis. It is hypothesized that neuroprotection can be achieved by inhibition on pro-apoptotic pathways or activation of survival pathways. By western blot analysis, we found that polysaccharides from Nerium indicum (Oleander) activate the PDK-1- Akt survival signaling pathway while the extract from Lycium barbarum (Gou-Qi-Zi) inhibits A -triggered PKR and JNK phosphorylation. All these extracts can protect neurons against A toxicity by inhibition on caspase-3 activity. In conclusion, it is possible to make use of protein kinases to screen potential neuroprotective agents from Chinese medicine. Acknowledgement: This work is supported by Area of Excellence (AoE/P-10/01).-
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofNeurosignals-
dc.rightsNeurosignals. Copyright © S Karger AG.en_HK
dc.titleProtein kinases as technological platforms to screen neuroprotective agents from chinese medicineen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailYuen, WH: yuenwh@HKUCC.hku.hken_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000095356-
dc.identifier.hkuros124885en_HK
dc.identifier.hkuros148397-
dc.identifier.hkuros107928-
dc.identifier.volume15-
dc.identifier.issue3-
dc.identifier.spage133, abstract no. P-36/24-
dc.identifier.epage133, abstract no. P-36/24-
dc.publisher.placeSwitzerland-

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