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Article: Id proteins expression in prostate cancer: High-level expression of Id-4 in primary prostate cancer is associated with development of metastases

TitleId proteins expression in prostate cancer: High-level expression of Id-4 in primary prostate cancer is associated with development of metastases
Authors
KeywordsId
Metastasis
Prostate cancer
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
Citation
Modern Pathology, 2006, v. 19 n. 7, p. 931-941 How to Cite?
AbstractA major cause of treatment failure for prostate cancer is the development of androgen-independent metastatic disease. Id protein family, a group of basic helix-loop-helix transcription factors, has been shown to be involved in carcinogenesis and a prognostic marker in several types of human cancers. In this study, we examined the expressions of four Id proteins, Id-1, -2, -3 and -4, in 125 clinical prostate cancer specimens as well as 40 nodular hyperplasia specimens by immunohistochemistry. The expressions of Id proteins were correlated with Gleason grading and metastatic progress of the tumors. We found that Id proteins were dysregulated in prostate cancer. Id-1 and -2 expressions were elevated while Id-3 and -4 expressions were reduced in prostate cancers compared to nodular hyperplasia. Cytoplasmic staining of Id-1 (P=0.013) and nuclear staining of Id-2 (P=0.001) and Id-4 (P<0.001) were positively correlated with Gleason score. The results indicate that these Id proteins may play a positive role in the development of prostate cancer. In contrast, Id-3 might have an inverse relationship with prostate neoplastic transformation (P=0.002) and cancer progression (P=0.022). We found that Id-4 nuclear overexpression in the primary prostate cancers significantly increased the risks to the development of metastasis in the patients (odds ratio=3.215, 95% confidence interval=1.150-8.987, P=0.026). Our results suggest that in prostate cancer patients, differential Id proteins expressions may be a useful marker for poor prognosis, and Id-4 may be a potential prognostic marker for distant metastasis. © 2006 USCAP, Inc All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67900
ISSN
2015 Impact Factor: 5.485
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, HFen_HK
dc.contributor.authorChua, CWen_HK
dc.contributor.authorChan, YPen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorChan, KWen_HK
dc.date.accessioned2010-09-06T05:59:17Z-
dc.date.available2010-09-06T05:59:17Z-
dc.date.issued2006en_HK
dc.identifier.citationModern Pathology, 2006, v. 19 n. 7, p. 931-941en_HK
dc.identifier.issn0893-3952en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67900-
dc.description.abstractA major cause of treatment failure for prostate cancer is the development of androgen-independent metastatic disease. Id protein family, a group of basic helix-loop-helix transcription factors, has been shown to be involved in carcinogenesis and a prognostic marker in several types of human cancers. In this study, we examined the expressions of four Id proteins, Id-1, -2, -3 and -4, in 125 clinical prostate cancer specimens as well as 40 nodular hyperplasia specimens by immunohistochemistry. The expressions of Id proteins were correlated with Gleason grading and metastatic progress of the tumors. We found that Id proteins were dysregulated in prostate cancer. Id-1 and -2 expressions were elevated while Id-3 and -4 expressions were reduced in prostate cancers compared to nodular hyperplasia. Cytoplasmic staining of Id-1 (P=0.013) and nuclear staining of Id-2 (P=0.001) and Id-4 (P<0.001) were positively correlated with Gleason score. The results indicate that these Id proteins may play a positive role in the development of prostate cancer. In contrast, Id-3 might have an inverse relationship with prostate neoplastic transformation (P=0.002) and cancer progression (P=0.022). We found that Id-4 nuclear overexpression in the primary prostate cancers significantly increased the risks to the development of metastasis in the patients (odds ratio=3.215, 95% confidence interval=1.150-8.987, P=0.026). Our results suggest that in prostate cancer patients, differential Id proteins expressions may be a useful marker for poor prognosis, and Id-4 may be a potential prognostic marker for distant metastasis. © 2006 USCAP, Inc All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/en_HK
dc.relation.ispartofModern Pathologyen_HK
dc.subjectIden_HK
dc.subjectMetastasisen_HK
dc.subjectProstate canceren_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCell Nucleus - metabolismen_HK
dc.subject.meshCell Transformation, Neoplastic - metabolism - pathologyen_HK
dc.subject.meshCytoplasm - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshInhibitor of Differentiation Protein 1 - metabolismen_HK
dc.subject.meshInhibitor of Differentiation Protein 2 - metabolismen_HK
dc.subject.meshInhibitor of Differentiation Proteins - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Metastasisen_HK
dc.subject.meshNeoplasm Proteins - metabolismen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProstatic Hyperplasia - metabolism - pathologyen_HK
dc.subject.meshProstatic Neoplasms - metabolism - pathologyen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshTissue Array Analysisen_HK
dc.subject.meshTumor Markers, Biological - metabolismen_HK
dc.titleId proteins expression in prostate cancer: High-level expression of Id-4 in primary prostate cancer is associated with development of metastasesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0893-3952&volume=19&issue=7&spage=931&epage=41&date=2006&atitle=Id+proteins+expression+in+prostate+cancer:+high-level+expression+of+Id-4+in+primary+prostate+cancer+is+associated+with+development+of+metastasesen_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/modpathol.3800602en_HK
dc.identifier.pmid16575399-
dc.identifier.scopuseid_2-s2.0-33745218275en_HK
dc.identifier.hkuros118295en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745218275&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue7en_HK
dc.identifier.spage931en_HK
dc.identifier.epage941en_HK
dc.identifier.isiWOS:000238311800006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, HF=14018633400en_HK
dc.identifier.scopusauthoridChua, CW=9437494600en_HK
dc.identifier.scopusauthoridChan, YP=14009821700en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.citeulike571891-

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