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Article: Immune modulatory effects of neural cell adhesion molecules on lipopolysaccharide-induced nitric oxide production by cultured glia

TitleImmune modulatory effects of neural cell adhesion molecules on lipopolysaccharide-induced nitric oxide production by cultured glia
Authors
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/molbrainres
Citation
Molecular Brain Research, 2000, v. 81 n. 1-2, p. 197-201 How to Cite?
AbstractActivation of glial cells often occurs at sites of neuronal injury or death and where there is disruption of communication between glia and neurons. We have previously reported that neurons exert an inhibitory influence on LPS-stimulated nitric oxide (NO) production in glial cells. We hypothesized that neural cell adhesion molecules (NCAM) might mediate this inhibitory effect, and this study was designed to elucidate the role of NCAM on lipopolysaccharide (LPS)-induced NO production. We found that soluble NCAMs reduced LPS-stimulated NO production by cultured glia. A monoclonal antibody that recognizes the third immunoglobulin (Ig) domain and can mimic the functions of NCAMs reduced LPS-stimulated NO production, whereas another antibody that binds to other regions of the NCAM did not modulate NO production. Using a 10-amino acid peptide from the third Ig domain of the NCAM, a peptide fragment within the region recognized by the NCAM antibody, mimics the effect of the molecule in reducing NO production. This study demonstrated that NCAMs could modulate LPS-stimulated NO production, most likely via interaction between NCAMs. These results suggest that neuron-glia interactions via NCAMs play an important role in regulating the activities of glial cells in the brain. (C) 2000 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/67897
ISSN
2007 Impact Factor: 1.997
2008 SCImago Journal Rankings: 1.457
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, RCCen_HK
dc.contributor.authorHudson, Pen_HK
dc.contributor.authorWilson, Ben_HK
dc.contributor.authorLiu, Ben_HK
dc.contributor.authorAbel, Hen_HK
dc.contributor.authorHemperly, Jen_HK
dc.contributor.authorHong, JSen_HK
dc.date.accessioned2010-09-06T05:59:16Z-
dc.date.available2010-09-06T05:59:16Z-
dc.date.issued2000en_HK
dc.identifier.citationMolecular Brain Research, 2000, v. 81 n. 1-2, p. 197-201en_HK
dc.identifier.issn0169-328Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67897-
dc.description.abstractActivation of glial cells often occurs at sites of neuronal injury or death and where there is disruption of communication between glia and neurons. We have previously reported that neurons exert an inhibitory influence on LPS-stimulated nitric oxide (NO) production in glial cells. We hypothesized that neural cell adhesion molecules (NCAM) might mediate this inhibitory effect, and this study was designed to elucidate the role of NCAM on lipopolysaccharide (LPS)-induced NO production. We found that soluble NCAMs reduced LPS-stimulated NO production by cultured glia. A monoclonal antibody that recognizes the third immunoglobulin (Ig) domain and can mimic the functions of NCAMs reduced LPS-stimulated NO production, whereas another antibody that binds to other regions of the NCAM did not modulate NO production. Using a 10-amino acid peptide from the third Ig domain of the NCAM, a peptide fragment within the region recognized by the NCAM antibody, mimics the effect of the molecule in reducing NO production. This study demonstrated that NCAMs could modulate LPS-stimulated NO production, most likely via interaction between NCAMs. These results suggest that neuron-glia interactions via NCAMs play an important role in regulating the activities of glial cells in the brain. (C) 2000 Elsevier Science B.V.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/molbrainresen_HK
dc.relation.ispartofMolecular Brain Researchen_HK
dc.rightsMolecular Brain Research. Copyright © Elsevier BV.en_HK
dc.subject.meshAdjuvants, Immunologicen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshBrain - cytology - physiologyen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshEscherichia colien_HK
dc.subject.meshLipopolysaccharides - pharmacologyen_HK
dc.subject.meshMiceen_HK
dc.subject.meshNeural Cell Adhesion Molecules - chemistry - pharmacologyen_HK
dc.subject.meshNeuroglia - drug effects - immunology - physiologyen_HK
dc.subject.meshNitric Oxide - biosynthesisen_HK
dc.subject.meshNitrites - metabolismen_HK
dc.subject.meshPeptide Fragments - pharmacologyen_HK
dc.titleImmune modulatory effects of neural cell adhesion molecules on lipopolysaccharide-induced nitric oxide production by cultured gliaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0169-328X&volume=81&spage=197&epage=201&date=2000&atitle=Immune+modulatory+effects+of+neural+cell+adhesion+molecules+on+lipopolysaccharide-induced+nitric+oxide+production+by+cultured+gliaen_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0169-328X(00)00175-3en_HK
dc.identifier.pmid11000493-
dc.identifier.scopuseid_2-s2.0-0034734782en_HK
dc.identifier.hkuros64033en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034734782&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume81en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage197en_HK
dc.identifier.epage201en_HK
dc.identifier.isiWOS:000089838000021-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK
dc.identifier.scopusauthoridHudson, P=35566903000en_HK
dc.identifier.scopusauthoridWilson, B=35243580200en_HK
dc.identifier.scopusauthoridLiu, B=36079151900en_HK
dc.identifier.scopusauthoridAbel, H=7103073193en_HK
dc.identifier.scopusauthoridHemperly, J=6701592327en_HK
dc.identifier.scopusauthoridHong, JS=7404117981en_HK

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