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Article: Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer

TitleSignificance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer
Authors
KeywordsE-cadherin
Gleason score
Metastasis
Prostatic cancer
TWIST
Issue Date2007
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 2007, v. 50 n. 5, p. 648-658 How to Cite?
AbstractAim: Development of metastasis is one of the main causes of prostatic cancer-related death. We have previously found that up-regulation of TWIST, a highly conserved basic helix-loop-helix transcription factor, in prostatic cancer cells can promote epithelial to mesenchymal transition through down-regulation of E-cadherin. The present study aimed to investigate the prognostic significance of TWIST and to correlate TWIST and E-cadherin expression in prostatic cancer specimens. Methods and results: TWIST and E-cadherin expression was studied in 115 prostatic cancer specimens, eight cases of prostatic intraepithelial neoplasia and 37 cases of benign prostatic hyperplasia by immunohistochemistry. Increased cytoplasmic expression of TWIST was associated with malignant transformation of prostatic epithelium and histological progression of prostatic cancer, while nuclear TWIST expression was significant in predicting the metastatic potential of the primary prostatic cancer. In addition, high levels of TWIST expression were also significantly associated with aberrant E-cadherin expression. Conclusions: These results suggest that TWIST may serve as a prognostic marker for high-grade prostatic cancer. In addition, up-regulation of TWIST in combination with aberrant E-cadherin expression in primary prostatic cancer specimens may predict development of distal metastatic disease. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/67879
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, HFen_HK
dc.contributor.authorChua, CWen_HK
dc.contributor.authorChan, YPen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorChan, KWen_HK
dc.date.accessioned2010-09-06T05:59:06Z-
dc.date.available2010-09-06T05:59:06Z-
dc.date.issued2007en_HK
dc.identifier.citationHistopathology, 2007, v. 50 n. 5, p. 648-658en_HK
dc.identifier.issn0309-0167en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67879-
dc.description.abstractAim: Development of metastasis is one of the main causes of prostatic cancer-related death. We have previously found that up-regulation of TWIST, a highly conserved basic helix-loop-helix transcription factor, in prostatic cancer cells can promote epithelial to mesenchymal transition through down-regulation of E-cadherin. The present study aimed to investigate the prognostic significance of TWIST and to correlate TWIST and E-cadherin expression in prostatic cancer specimens. Methods and results: TWIST and E-cadherin expression was studied in 115 prostatic cancer specimens, eight cases of prostatic intraepithelial neoplasia and 37 cases of benign prostatic hyperplasia by immunohistochemistry. Increased cytoplasmic expression of TWIST was associated with malignant transformation of prostatic epithelium and histological progression of prostatic cancer, while nuclear TWIST expression was significant in predicting the metastatic potential of the primary prostatic cancer. In addition, high levels of TWIST expression were also significantly associated with aberrant E-cadherin expression. Conclusions: These results suggest that TWIST may serve as a prognostic marker for high-grade prostatic cancer. In addition, up-regulation of TWIST in combination with aberrant E-cadherin expression in primary prostatic cancer specimens may predict development of distal metastatic disease. © 2007 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_HK
dc.relation.ispartofHistopathologyen_HK
dc.rightsHistopathology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectE-cadherinen_HK
dc.subjectGleason scoreen_HK
dc.subjectMetastasisen_HK
dc.subjectProstatic canceren_HK
dc.subjectTWISTen_HK
dc.subject.meshAdenocarcinoma - metabolism - secondaryen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCadherins - metabolismen_HK
dc.subject.meshCell Nucleus - metabolismen_HK
dc.subject.meshCytoplasm - metabolismen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFluorescent Antibody Technique, Indirecten_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoenzyme Techniquesen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Metastasisen_HK
dc.subject.meshNuclear Proteins - metabolismen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProstatic Hyperplasia - metabolism - pathologyen_HK
dc.subject.meshProstatic Intraepithelial Neoplasia - metabolism - secondaryen_HK
dc.subject.meshProstatic Neoplasms - metabolism - pathologyen_HK
dc.subject.meshTissue Array Analysisen_HK
dc.subject.meshTumor Markers, Biological - metabolismen_HK
dc.subject.meshTwist Transcription Factor - metabolismen_HK
dc.subject.meshUp-Regulationen_HK
dc.titleSignificance of TWIST and E-cadherin expression in the metastatic progression of prostatic canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0309-0167&volume=50&issue=5&spage=648&epage=58&date=2007&atitle=Significance+of+TWIST+and+E-cadherin+expression+in+the+metastatic+progression+of+prostatic+canceren_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2559.2007.02665.xen_HK
dc.identifier.pmid17394502-
dc.identifier.scopuseid_2-s2.0-33947639964en_HK
dc.identifier.hkuros128153en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947639964&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue5en_HK
dc.identifier.spage648en_HK
dc.identifier.epage658en_HK
dc.identifier.isiWOS:000245230300015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, HF=14018633400en_HK
dc.identifier.scopusauthoridChua, CW=9437494600en_HK
dc.identifier.scopusauthoridChan, YP=14009821700en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.citeulike1193773-

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