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Article: Evidence of a novel biomarker, αs1-Casein, a milk protein, in benign prostate hyperplasia

TitleEvidence of a novel biomarker, αs1-Casein, a milk protein, in benign prostate hyperplasia
Authors
Keywords[alpha]s1-Casein
Marker
Diagnosis
Benign prostate hyperplasia
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/pcan
Citation
Prostate Cancer And Prostatic Diseases, 2006, v. 9 n. 3, p. 293-297 How to Cite?
AbstractBenign prostate hyperplasia (BPH) is a common disease in elderly men. Although it is a non-malignant disease, it has a significant detrimental impact on the quality of life in patients with late-stage disease. Owing to the lack of specific markers, diagnosis of early-stage BPH has been proven unsuccessful. Recently, using two-dimensional electrophoresis, we identified a group of prostatic secretory proteins that are specifically produced by BPH cells (Xu et al., Electrophoresis 2003; 24: 1311). In this study, we investigated the potential diagnostic value of one of the secretory proteins, αs1-Casein, in BPH by inmmunohistological staining of normal, BPH and prostate cancer tissues. We found that 90% (20 out of 22) of BPH tissues showed moderate to strong αs1-Casein protein expression whereas none of the normal tissues (0 out of 10) and less than 10% of the prostate cancer tissues (3 out of 30) showed similar staining intensity. Our results suggest that αs1-Casein may be a potential biomarker for early identification of BPH patients. © 2006 Nature Publishing Group All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67877
ISSN
2015 Impact Factor: 3.803
2015 SCImago Journal Rankings: 1.588
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, Ken_HK
dc.contributor.authorLing, MTen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorWong, YCen_HK
dc.date.accessioned2010-09-06T05:59:05Z-
dc.date.available2010-09-06T05:59:05Z-
dc.date.issued2006en_HK
dc.identifier.citationProstate Cancer And Prostatic Diseases, 2006, v. 9 n. 3, p. 293-297en_HK
dc.identifier.issn1365-7852en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67877-
dc.description.abstractBenign prostate hyperplasia (BPH) is a common disease in elderly men. Although it is a non-malignant disease, it has a significant detrimental impact on the quality of life in patients with late-stage disease. Owing to the lack of specific markers, diagnosis of early-stage BPH has been proven unsuccessful. Recently, using two-dimensional electrophoresis, we identified a group of prostatic secretory proteins that are specifically produced by BPH cells (Xu et al., Electrophoresis 2003; 24: 1311). In this study, we investigated the potential diagnostic value of one of the secretory proteins, αs1-Casein, in BPH by inmmunohistological staining of normal, BPH and prostate cancer tissues. We found that 90% (20 out of 22) of BPH tissues showed moderate to strong αs1-Casein protein expression whereas none of the normal tissues (0 out of 10) and less than 10% of the prostate cancer tissues (3 out of 30) showed similar staining intensity. Our results suggest that αs1-Casein may be a potential biomarker for early identification of BPH patients. © 2006 Nature Publishing Group All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/pcanen_HK
dc.relation.ispartofProstate Cancer and Prostatic Diseasesen_HK
dc.subject[alpha]s1-Casein-
dc.subjectMarker-
dc.subjectDiagnosis-
dc.subjectBenign prostate hyperplasia-
dc.subject.meshAdenocarcinoma - metabolism - pathologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAutopsyen_HK
dc.subject.meshCaseins - isolation & purification - metabolismen_HK
dc.subject.meshDiagnosis, Differentialen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMilk Proteins - isolation & purificationen_HK
dc.subject.meshProstate - metabolism - pathologyen_HK
dc.subject.meshProstatic Hyperplasia - diagnosis - metabolism - pathologyen_HK
dc.subject.meshProstatic Neoplasms - metabolism - pathologyen_HK
dc.subject.meshProstatic Secretory Proteins - isolation & purification - metabolismen_HK
dc.subject.meshTumor Markers, Biological - isolation & purification - metabolismen_HK
dc.subject.meshUp-Regulationen_HK
dc.titleEvidence of a novel biomarker, αs1-Casein, a milk protein, in benign prostate hyperplasiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1365-7852&volume=9&spage=293&epage=297&date=2006&atitle=Evidence+of+a+novel+biomarker,+s1-Casein,+a+milk+protein,+in+benign+prostatic+hyperplasia.en_HK
dc.identifier.emailLing, MT:patling@hkucc.hku.hken_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityLing, MT=rp00449en_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/sj.pcan.4500872en_HK
dc.identifier.pmid16683014-
dc.identifier.scopuseid_2-s2.0-33748263580en_HK
dc.identifier.hkuros133112en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748263580&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue3en_HK
dc.identifier.spage293en_HK
dc.identifier.epage297en_HK
dc.identifier.isiWOS:000240144800025-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXu, K=7403281993en_HK
dc.identifier.scopusauthoridLing, MT=7102229780en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.citeulike620573-

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