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Article: Evidence of a novel biomarker, αs1-Casein, a milk protein, in benign prostate hyperplasia
Title | Evidence of a novel biomarker, αs1-Casein, a milk protein, in benign prostate hyperplasia |
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Authors | |
Keywords | [alpha]s1-Casein Marker Diagnosis Benign prostate hyperplasia |
Issue Date | 2006 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/pcan |
Citation | Prostate Cancer And Prostatic Diseases, 2006, v. 9 n. 3, p. 293-297 How to Cite? |
Abstract | Benign prostate hyperplasia (BPH) is a common disease in elderly men. Although it is a non-malignant disease, it has a significant detrimental impact on the quality of life in patients with late-stage disease. Owing to the lack of specific markers, diagnosis of early-stage BPH has been proven unsuccessful. Recently, using two-dimensional electrophoresis, we identified a group of prostatic secretory proteins that are specifically produced by BPH cells (Xu et al., Electrophoresis 2003; 24: 1311). In this study, we investigated the potential diagnostic value of one of the secretory proteins, αs1-Casein, in BPH by inmmunohistological staining of normal, BPH and prostate cancer tissues. We found that 90% (20 out of 22) of BPH tissues showed moderate to strong αs1-Casein protein expression whereas none of the normal tissues (0 out of 10) and less than 10% of the prostate cancer tissues (3 out of 30) showed similar staining intensity. Our results suggest that αs1-Casein may be a potential biomarker for early identification of BPH patients. © 2006 Nature Publishing Group All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/67877 |
ISSN | 2023 Impact Factor: 5.1 2023 SCImago Journal Rankings: 1.711 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, K | en_HK |
dc.contributor.author | Ling, MT | en_HK |
dc.contributor.author | Wang, X | en_HK |
dc.contributor.author | Wong, YC | en_HK |
dc.date.accessioned | 2010-09-06T05:59:05Z | - |
dc.date.available | 2010-09-06T05:59:05Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Prostate Cancer And Prostatic Diseases, 2006, v. 9 n. 3, p. 293-297 | en_HK |
dc.identifier.issn | 1365-7852 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67877 | - |
dc.description.abstract | Benign prostate hyperplasia (BPH) is a common disease in elderly men. Although it is a non-malignant disease, it has a significant detrimental impact on the quality of life in patients with late-stage disease. Owing to the lack of specific markers, diagnosis of early-stage BPH has been proven unsuccessful. Recently, using two-dimensional electrophoresis, we identified a group of prostatic secretory proteins that are specifically produced by BPH cells (Xu et al., Electrophoresis 2003; 24: 1311). In this study, we investigated the potential diagnostic value of one of the secretory proteins, αs1-Casein, in BPH by inmmunohistological staining of normal, BPH and prostate cancer tissues. We found that 90% (20 out of 22) of BPH tissues showed moderate to strong αs1-Casein protein expression whereas none of the normal tissues (0 out of 10) and less than 10% of the prostate cancer tissues (3 out of 30) showed similar staining intensity. Our results suggest that αs1-Casein may be a potential biomarker for early identification of BPH patients. © 2006 Nature Publishing Group All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/pcan | en_HK |
dc.relation.ispartof | Prostate Cancer and Prostatic Diseases | en_HK |
dc.subject | [alpha]s1-Casein | - |
dc.subject | Marker | - |
dc.subject | Diagnosis | - |
dc.subject | Benign prostate hyperplasia | - |
dc.subject.mesh | Adenocarcinoma - metabolism - pathology | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Aged, 80 and over | en_HK |
dc.subject.mesh | Autopsy | en_HK |
dc.subject.mesh | Caseins - isolation & purification - metabolism | en_HK |
dc.subject.mesh | Diagnosis, Differential | en_HK |
dc.subject.mesh | Gene Expression Regulation, Neoplastic | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunohistochemistry | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Milk Proteins - isolation & purification | en_HK |
dc.subject.mesh | Prostate - metabolism - pathology | en_HK |
dc.subject.mesh | Prostatic Hyperplasia - diagnosis - metabolism - pathology | en_HK |
dc.subject.mesh | Prostatic Neoplasms - metabolism - pathology | en_HK |
dc.subject.mesh | Prostatic Secretory Proteins - isolation & purification - metabolism | en_HK |
dc.subject.mesh | Tumor Markers, Biological - isolation & purification - metabolism | en_HK |
dc.subject.mesh | Up-Regulation | en_HK |
dc.title | Evidence of a novel biomarker, αs1-Casein, a milk protein, in benign prostate hyperplasia | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1365-7852&volume=9&spage=293&epage=297&date=2006&atitle=Evidence+of+a+novel+biomarker,+s1-Casein,+a+milk+protein,+in+benign+prostatic+hyperplasia. | en_HK |
dc.identifier.email | Ling, MT:patling@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, YC:ycwong@hkucc.hku.hk | en_HK |
dc.identifier.authority | Ling, MT=rp00449 | en_HK |
dc.identifier.authority | Wong, YC=rp00316 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1038/sj.pcan.4500872 | en_HK |
dc.identifier.pmid | 16683014 | - |
dc.identifier.scopus | eid_2-s2.0-33748263580 | en_HK |
dc.identifier.hkuros | 133112 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33748263580&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 9 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 293 | en_HK |
dc.identifier.epage | 297 | en_HK |
dc.identifier.isi | WOS:000240144800025 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Xu, K=7403281993 | en_HK |
dc.identifier.scopusauthorid | Ling, MT=7102229780 | en_HK |
dc.identifier.scopusauthorid | Wang, X=7501854829 | en_HK |
dc.identifier.scopusauthorid | Wong, YC=7403041798 | en_HK |
dc.identifier.citeulike | 620573 | - |
dc.identifier.issnl | 1365-7852 | - |