File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Axotomy induces cytochrome c release in retinal ganglion cells

TitleAxotomy induces cytochrome c release in retinal ganglion cells
Authors
KeywordsApoptosis
Caspase
Mitochondria
Optic nerve
Transection
Issue Date2003
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2003, v. 14 n. 2, p. 279-282 How to Cite?
AbstractActivation of caspase-3 and -9 has been implicated in the death of axotomized retinal ganglion cells (RGCs). The upstream pathways involved in the activation of these caspases, however, remain unknown. The aim of the current study is to examine the role of cytochrome c release in axotomized RGC death using immunohistochemistry. We found that while only a low level of cytochrome c immunoreactivity was evident in normal retina, cytochrome c immunoreactivity increased markedly at 1 day post-axotomy, peaked at 3 days post-axotomy, and decreased thereafter. In addition, cytochrome c immunoreactivity localized almost exclusively to RGCs, suggesting that the cytochrome c release observed was injury-related. Our data indicate that cytochrome c release potentially contributes to the death of axotomized RGCs. © 2003 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/67876
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ZHen_HK
dc.contributor.authorYip, HKen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-06T05:59:04Z-
dc.date.available2010-09-06T05:59:04Z-
dc.date.issued2003en_HK
dc.identifier.citationNeuroreport, 2003, v. 14 n. 2, p. 279-282en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67876-
dc.description.abstractActivation of caspase-3 and -9 has been implicated in the death of axotomized retinal ganglion cells (RGCs). The upstream pathways involved in the activation of these caspases, however, remain unknown. The aim of the current study is to examine the role of cytochrome c release in axotomized RGC death using immunohistochemistry. We found that while only a low level of cytochrome c immunoreactivity was evident in normal retina, cytochrome c immunoreactivity increased markedly at 1 day post-axotomy, peaked at 3 days post-axotomy, and decreased thereafter. In addition, cytochrome c immunoreactivity localized almost exclusively to RGCs, suggesting that the cytochrome c release observed was injury-related. Our data indicate that cytochrome c release potentially contributes to the death of axotomized RGCs. © 2003 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsThis is a non-final version of an article published in final form in NeuroReport, 2003, v. 14 n. 2, p. 279-282en_HK
dc.subjectApoptosisen_HK
dc.subjectCaspaseen_HK
dc.subjectMitochondriaen_HK
dc.subjectOptic nerveen_HK
dc.subjectTransectionen_HK
dc.subject.meshAxotomy - methods-
dc.subject.meshCytochrome c Group - analysis - biosynthesis - secretion-
dc.subject.meshEnzyme Induction - physiology-
dc.subject.meshOptic Nerve - physiology-
dc.subject.meshRetinal Ganglion Cells - chemistry - enzymology - secretion-
dc.titleAxotomy induces cytochrome c release in retinal ganglion cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ZH:zelda@hku.hken_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ZH=rp01588en_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00001756-200302100-00025en_HK
dc.identifier.pmid12598746-
dc.identifier.scopuseid_2-s2.0-0037428723en_HK
dc.identifier.hkuros75903en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037428723&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue2en_HK
dc.identifier.spage279en_HK
dc.identifier.epage282en_HK
dc.identifier.isiWOS:000181452500025-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, ZH=6507483375en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats