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Article: Major biological effects of neurotrophic factors on retinal ganglion cells in mammals

TitleMajor biological effects of neurotrophic factors on retinal ganglion cells in mammals
Authors
Issue Date1998
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
Biological Signals And Receptors, 1998, v. 7 n. 4, p. 220-226 How to Cite?
AbstractThe mammalian visual system, particularly retinal ganglion cells, has been used for studying the functions of neurotrophic factors on neurons for many years. The major biological effects of neurotrophic factors on retinal ganglion cells observed so far are the promotion of viability and axonal regeneration. However, there are still some controversies regarding the effects of neurotrophic factors on retinal ganglion cells in the literature. This review is aimed to summarize the available information on the biological actions of these neurotrophic factors on survival and axonal regeneration of retinal ganglion cells and the expressions of neurotrophic factor receptors in the retina. Generally, brain-derived neurotrophic factor, neurotrophin-4/5, fibroblast growth factor and glial cell line-derived neurotrophic factor increase the survival of retinal ganglion cells while the effect of ciliary neurotrophic factor on the viability of adult retinal ganglion cells is controversial. The ciliary neurotrophic factor is the only effective factor in promoting long distance axonal regeneration of retinal ganglion cells whereas brain-derived neurotrophic factor and neurotrophin-4/5 only enhance neurite sprouting within the retina.
Persistent Identifierhttp://hdl.handle.net/10722/67873
ISSN
2003 Impact Factor: 3.5
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCui, Qen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorYip, HKen_HK
dc.date.accessioned2010-09-06T05:59:03Z-
dc.date.available2010-09-06T05:59:03Z-
dc.date.issued1998en_HK
dc.identifier.citationBiological Signals And Receptors, 1998, v. 7 n. 4, p. 220-226en_HK
dc.identifier.issn1422-4933en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67873-
dc.description.abstractThe mammalian visual system, particularly retinal ganglion cells, has been used for studying the functions of neurotrophic factors on neurons for many years. The major biological effects of neurotrophic factors on retinal ganglion cells observed so far are the promotion of viability and axonal regeneration. However, there are still some controversies regarding the effects of neurotrophic factors on retinal ganglion cells in the literature. This review is aimed to summarize the available information on the biological actions of these neurotrophic factors on survival and axonal regeneration of retinal ganglion cells and the expressions of neurotrophic factor receptors in the retina. Generally, brain-derived neurotrophic factor, neurotrophin-4/5, fibroblast growth factor and glial cell line-derived neurotrophic factor increase the survival of retinal ganglion cells while the effect of ciliary neurotrophic factor on the viability of adult retinal ganglion cells is controversial. The ciliary neurotrophic factor is the only effective factor in promoting long distance axonal regeneration of retinal ganglion cells whereas brain-derived neurotrophic factor and neurotrophin-4/5 only enhance neurite sprouting within the retina.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofBiological Signals and Receptorsen_HK
dc.rightsBiological Signals and Receptors. Copyright © S Karger AG.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAxons - drug effectsen_HK
dc.subject.meshCell Survival - drug effectsen_HK
dc.subject.meshCytokines - pharmacologyen_HK
dc.subject.meshDenervationen_HK
dc.subject.meshGrowth Substances - pharmacologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMammals - physiologyen_HK
dc.subject.meshNerve Growth Factors - pharmacologyen_HK
dc.subject.meshNerve Regenerationen_HK
dc.subject.meshNerve Transferen_HK
dc.subject.meshNeurites - drug effectsen_HK
dc.subject.meshOptic Nerve Injuriesen_HK
dc.subject.meshReceptors, Nerve Growth Factor - drug effects - physiologyen_HK
dc.subject.meshRetinal Ganglion Cells - drug effectsen_HK
dc.subject.meshSchwann Cells - transplantationen_HK
dc.subject.meshVitreous Bodyen_HK
dc.titleMajor biological effects of neurotrophic factors on retinal ganglion cells in mammalsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1422-4933&volume=7&spage=220&epage=226&date=1998&atitle=Major+biological+effects+of+neurotrophic+factors+on+retinal+ganglion+cells+in+mammalsen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9730581-
dc.identifier.scopuseid_2-s2.0-0031706057en_HK
dc.identifier.hkuros37590en_HK
dc.identifier.volume7en_HK
dc.identifier.issue4en_HK
dc.identifier.spage220en_HK
dc.identifier.epage226en_HK
dc.identifier.isiWOS:000075823300002-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridCui, Q=7103080164en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK

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