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Article: Cytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters

TitleCytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters
Authors
KeywordsApoptosis
ganglion cells
mitochondria
optic nerve
signal transduction
Issue Date2004
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0364-3190
Citation
Neurochemical Research, 2004, v. 29 n. 11 SPEC. ISS., p. 2153-2161 How to Cite?
AbstractThis study examined the relationship between the distance of axotomy and the death of injured retinal ganglion cells (RGCs) in adult hamsters and the relationship of cytochrome c and caspase-3 on the death pathway of RGCs. The left optic nerve (ON) of adult hamsters was transected either at 1 or 3 mm away from the optic disc, and retrogradely labeled with Flurogold on the ON stump. After a predetermined period of postoperative time, the surviving RGCs were counted by retina flat-mount, and the activation of cytochrome c and caspase-3 were investigated by immunohistochemistry. Cell loss was found to be much faster (P < 0.01), more cells with cytochrome c were observed (P < 0.05) and the activation of caspase-3 was earlier when ON was transected 1 mm away from the optic disc than when was transected 3 mm away from the optic disc. Distance of axotomy affects the axotomized cell death rate where more RGCs died when the ON transection was applied closer to the eye. The timing of activation of caspase-3 in the RGCs may be linked to the distance of axotomy.
Persistent Identifierhttp://hdl.handle.net/10722/67868
ISSN
2015 Impact Factor: 2.472
2015 SCImago Journal Rankings: 1.102
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHe, MHen_HK
dc.contributor.authorCheung, ZHen_HK
dc.contributor.authorYu, EHen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-06T05:59:00Z-
dc.date.available2010-09-06T05:59:00Z-
dc.date.issued2004en_HK
dc.identifier.citationNeurochemical Research, 2004, v. 29 n. 11 SPEC. ISS., p. 2153-2161en_HK
dc.identifier.issn0364-3190en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67868-
dc.description.abstractThis study examined the relationship between the distance of axotomy and the death of injured retinal ganglion cells (RGCs) in adult hamsters and the relationship of cytochrome c and caspase-3 on the death pathway of RGCs. The left optic nerve (ON) of adult hamsters was transected either at 1 or 3 mm away from the optic disc, and retrogradely labeled with Flurogold on the ON stump. After a predetermined period of postoperative time, the surviving RGCs were counted by retina flat-mount, and the activation of cytochrome c and caspase-3 were investigated by immunohistochemistry. Cell loss was found to be much faster (P < 0.01), more cells with cytochrome c were observed (P < 0.05) and the activation of caspase-3 was earlier when ON was transected 1 mm away from the optic disc than when was transected 3 mm away from the optic disc. Distance of axotomy affects the axotomized cell death rate where more RGCs died when the ON transection was applied closer to the eye. The timing of activation of caspase-3 in the RGCs may be linked to the distance of axotomy.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0364-3190en_HK
dc.relation.ispartofNeurochemical Researchen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectApoptosisen_HK
dc.subjectganglion cellsen_HK
dc.subjectmitochondriaen_HK
dc.subjectoptic nerveen_HK
dc.subjectsignal transductionen_HK
dc.subject.meshAxotomy-
dc.subject.meshCaspases - metabolism-
dc.subject.meshCytochromes c - metabolism-
dc.subject.meshOptic Nerve - physiology-
dc.subject.meshRetinal Ganglion Cells - enzymology-
dc.titleCytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamstersen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ZH:zelda@hku.hken_HK
dc.identifier.emailTay, DKC:dkctay@hkucc.hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ZH=rp01588en_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11064-004-6889-6en_HK
dc.identifier.pmid15662850-
dc.identifier.scopuseid_2-s2.0-10844266488en_HK
dc.identifier.hkuros96793en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10844266488&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue11 SPEC. ISS.en_HK
dc.identifier.spage2153en_HK
dc.identifier.epage2161en_HK
dc.identifier.isiWOS:000225538200023-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHe, MH=7402608999en_HK
dc.identifier.scopusauthoridCheung, ZH=6507483375en_HK
dc.identifier.scopusauthoridYu, EH=12808967300en_HK
dc.identifier.scopusauthoridTay, DKC=7006796825en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK

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