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Article: Developmental changes of nitric oxide synthase expression in the rat hypothalamoneurohypophyseal system

TitleDevelopmental changes of nitric oxide synthase expression in the rat hypothalamoneurohypophyseal system
Authors
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28243
Citation
Anatomical Record - Part A Discoveries In Molecular, Cellular, And Evolutionary Biology, 2006, v. 288 n. 1, p. 36-45 How to Cite?
AbstractThe present study investigated the immunohistochemical localization of neuronal nitric oxide synthase (nNOS) in the hypothalamoneurohypophyseal system (HNS) of the developing rats on postnatal day 1 (PN1), 7 (PN7), 14 (PN14), 21 (PN21), and the adult rats. The nNOS-positive neurons were not discernable in the supraoptic nucleus (SON), the paraventricular nucleus (PVN), and the median eminence (ME) at PN1 and PN7. A few neurons positive for nNOS were first detected at PN14. At PN21, the nNOS-positive cells in SON and PVN rapidly increased in number. The pattern of nNOS expression at this stage approached that of the adult. Moreover, the increase of nNOS expression in the SON and PVN during the postnatal period was accompanied by the maturation of arginine vasopressin (AVP) and oxytocin (OT) neurons as indicated by the number and size of OT or AVP neurons in the SON and PVN. The patterns of AVP versus OT expression also reached that of the adult by the end of the third postnatal week. The time course of the change in nNOS expression coincided with the maturation of AVP and OT neurons in the HNS and suggested that NO synthesized by conversion of NOS is involved in the modulation of activity of neurons in the SON and PVN of the HNS. © 2005 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/67863
ISSN
2004 Impact Factor: 3.147
2015 SCImago Journal Rankings: 0.741
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Qen_HK
dc.contributor.authorScott, DEen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-09-06T05:58:57Z-
dc.date.available2010-09-06T05:58:57Z-
dc.date.issued2006en_HK
dc.identifier.citationAnatomical Record - Part A Discoveries In Molecular, Cellular, And Evolutionary Biology, 2006, v. 288 n. 1, p. 36-45en_HK
dc.identifier.issn0003-276Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67863-
dc.description.abstractThe present study investigated the immunohistochemical localization of neuronal nitric oxide synthase (nNOS) in the hypothalamoneurohypophyseal system (HNS) of the developing rats on postnatal day 1 (PN1), 7 (PN7), 14 (PN14), 21 (PN21), and the adult rats. The nNOS-positive neurons were not discernable in the supraoptic nucleus (SON), the paraventricular nucleus (PVN), and the median eminence (ME) at PN1 and PN7. A few neurons positive for nNOS were first detected at PN14. At PN21, the nNOS-positive cells in SON and PVN rapidly increased in number. The pattern of nNOS expression at this stage approached that of the adult. Moreover, the increase of nNOS expression in the SON and PVN during the postnatal period was accompanied by the maturation of arginine vasopressin (AVP) and oxytocin (OT) neurons as indicated by the number and size of OT or AVP neurons in the SON and PVN. The patterns of AVP versus OT expression also reached that of the adult by the end of the third postnatal week. The time course of the change in nNOS expression coincided with the maturation of AVP and OT neurons in the HNS and suggested that NO synthesized by conversion of NOS is involved in the modulation of activity of neurons in the SON and PVN of the HNS. © 2005 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28243en_HK
dc.relation.ispartofAnatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biologyen_HK
dc.rightsThe Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshArginine Vasopressin - biosynthesisen_HK
dc.subject.meshFluorescent Antibody Techniqueen_HK
dc.subject.meshHypothalamo-Hypophyseal System - growth & development - metabolismen_HK
dc.subject.meshInterneurons - cytologyen_HK
dc.subject.meshMedian Eminence - metabolismen_HK
dc.subject.meshNitric Oxide Synthase Type I - biosynthesisen_HK
dc.subject.meshOxytocin - biosynthesisen_HK
dc.subject.meshParaventricular Hypothalamic Nucleus - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleDevelopmental changes of nitric oxide synthase expression in the rat hypothalamoneurohypophyseal systemen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1552-4884&volume=288A&spage=36&epage=45&date=2006&atitle=Developmental+changes+of+nitric+oxide+synthase+expression+in+the+rat+hypothalamoneurohypophyseal+systemen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/ar.a.20271en_HK
dc.identifier.pmid16342209-
dc.identifier.scopuseid_2-s2.0-30344478528en_HK
dc.identifier.hkuros115065en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-30344478528&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume288en_HK
dc.identifier.issue1en_HK
dc.identifier.spage36en_HK
dc.identifier.epage45en_HK
dc.identifier.isiWOS:000234496500006-
dc.identifier.scopusauthoridYuan, Q=7202814773en_HK
dc.identifier.scopusauthoridScott, DE=7404951677en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK

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