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Article: Effect of aging on the expression of adrenomedullin and its receptor component proteins in the male reproductive system of the rat

TitleEffect of aging on the expression of adrenomedullin and its receptor component proteins in the male reproductive system of the rat
Authors
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://biomed.gerontologyjournals.org/
Citation
Journals Of Gerontology - Series A Biological Sciences And Medical Sciences, 2007, v. 62 n. 12, p. 1346-1351 How to Cite?
AbstractThis study investigated the levels of adrenomedullin (AM) and the gene expression of AM, calcitonin receptor-like receptor (CRLR), receptor activity-modifying proteins (RAMPs), and receptor-coupling protein (RCP) in the testis, ventral prostate, seminal vesicle, and epididymis in rats aged 3, 12, and 20 months by radioimmunoassay and semiquantitative reverse transcriptionpolymerase chain reaction (RT-PCR). The results indicate an age-related increase in AM and its messenger RNA (mRNA) levels in the testis and decrease in the sex accessory glands. The gene expression of CRLR and RCP decreased only in the sex accessory glands. The changes in the gene expression of RAMPs suggest that the major increase was in CGRP receptors in the testis, whereas the major deceases in the ventral prostate and the seminal vesicles might be CGRP and AM receptors, respectively. The decreases in these receptors were similar in the epididymis. The results suggest possible roles of AM in the male reproductive system during aging. Copyright 2007 by The Gerontological Society of America.
Persistent Identifierhttp://hdl.handle.net/10722/67862
ISSN
2015 Impact Factor: 5.476
2015 SCImago Journal Rankings: 2.675
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, YYen_HK
dc.contributor.authorO, WSen_HK
dc.contributor.authorTang, Fen_HK
dc.date.accessioned2010-09-06T05:58:57Z-
dc.date.available2010-09-06T05:58:57Z-
dc.date.issued2007en_HK
dc.identifier.citationJournals Of Gerontology - Series A Biological Sciences And Medical Sciences, 2007, v. 62 n. 12, p. 1346-1351en_HK
dc.identifier.issn1079-5006en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67862-
dc.description.abstractThis study investigated the levels of adrenomedullin (AM) and the gene expression of AM, calcitonin receptor-like receptor (CRLR), receptor activity-modifying proteins (RAMPs), and receptor-coupling protein (RCP) in the testis, ventral prostate, seminal vesicle, and epididymis in rats aged 3, 12, and 20 months by radioimmunoassay and semiquantitative reverse transcriptionpolymerase chain reaction (RT-PCR). The results indicate an age-related increase in AM and its messenger RNA (mRNA) levels in the testis and decrease in the sex accessory glands. The gene expression of CRLR and RCP decreased only in the sex accessory glands. The changes in the gene expression of RAMPs suggest that the major increase was in CGRP receptors in the testis, whereas the major deceases in the ventral prostate and the seminal vesicles might be CGRP and AM receptors, respectively. The decreases in these receptors were similar in the epididymis. The results suggest possible roles of AM in the male reproductive system during aging. Copyright 2007 by The Gerontological Society of America.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://biomed.gerontologyjournals.org/en_HK
dc.relation.ispartofJournals of Gerontology - Series A Biological Sciences and Medical Sciencesen_HK
dc.rightsJournals of Gerontology. Series A: Biological Sciences & Medical Sciences. Copyright © Oxford University Press.en_HK
dc.subject.meshAdrenomedullin - analysis - genetics - physiologyen_HK
dc.subject.meshAging - metabolismen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCalcitonin Receptor-Like Proteinen_HK
dc.subject.meshGenitalia, Male - chemistry - metabolismen_HK
dc.subject.meshIntracellular Signaling Peptides and Proteins - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMembrane Proteins - geneticsen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReceptor Activity-Modifying Proteinsen_HK
dc.subject.meshReceptors, Calcitonin - geneticsen_HK
dc.subject.meshReceptors, Calcitonin Gene-Related Peptide - geneticsen_HK
dc.subject.meshTestosterone - blooden_HK
dc.titleEffect of aging on the expression of adrenomedullin and its receptor component proteins in the male reproductive system of the raten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1079-5006&volume=62A&issue=12&spage=1346&epage=1351&date=2007&atitle=Effect+of+aging+on+the+expression+of+adrenomedullin+and+its+receptor+component+proteins+in+the+male+reproductive+system+of+the+raten_HK
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_HK
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid18166684-
dc.identifier.scopuseid_2-s2.0-38749100559en_HK
dc.identifier.hkuros141395en_HK
dc.identifier.hkuros149664-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38749100559&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume62en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1346en_HK
dc.identifier.epage1351en_HK
dc.identifier.isiWOS:000253829500004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, YY=8293496300en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK

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