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Article: Id-1 modulates senescence and TGF-β1 sensitivity in prostate epithelial cells

TitleId-1 modulates senescence and TGF-β1 sensitivity in prostate epithelial cells
Authors
Issue Date2006
PublisherPortland Press Ltd. The Journal's web site is located at http://www.biolcell.org/
Citation
Biology Of The Cell, 2006, v. 98 n. 9, p. 523-533 How to Cite?
AbstractBackground information. Loss of sensitivity to TGF-β1 (transforming growth factor β1)-induced growth arrest is an important step towards malignant transformation in human epithelial cells, and Id-1 (inhibitor of differentiation or DNA binding-1) has been associated with cell proliferation and cell-cycle progression. Here, we investigated the role of Id-1 in cellular sensitivity to TGF-β1. Results. Using an immortalized prostate epithelial cell line, NPTX cells, we suppressed Id-1 expression through antisense strategy. We found that inhibition of Id-1 expression suppressed cell proliferation and at the same time induced cellular senescence and G2/M cell-cycle arrest. In addition, inactivation of Id-1 made cells more vulnerable to TGF-β1-induced growth arrest. The sensitization effect on TGF-β1 was associated with up-regulation of two downstream effectors of the TGF-β1 pathway, p21WAF1/Cip1 and p27KIP1. Conclusion. Our results indicate that endogenous Id-1 levels might be a crucial factor in the development of resistance to TGF-β1-induced growth suppression in human prostate epithelial cells.
Persistent Identifierhttp://hdl.handle.net/10722/67844
ISSN
2015 Impact Factor: 2.552
2015 SCImago Journal Rankings: 1.812
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDi, Ken_HK
dc.contributor.authorLing, MTen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorWang, Xen_HK
dc.date.accessioned2010-09-06T05:58:47Z-
dc.date.available2010-09-06T05:58:47Z-
dc.date.issued2006en_HK
dc.identifier.citationBiology Of The Cell, 2006, v. 98 n. 9, p. 523-533en_HK
dc.identifier.issn0248-4900en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67844-
dc.description.abstractBackground information. Loss of sensitivity to TGF-β1 (transforming growth factor β1)-induced growth arrest is an important step towards malignant transformation in human epithelial cells, and Id-1 (inhibitor of differentiation or DNA binding-1) has been associated with cell proliferation and cell-cycle progression. Here, we investigated the role of Id-1 in cellular sensitivity to TGF-β1. Results. Using an immortalized prostate epithelial cell line, NPTX cells, we suppressed Id-1 expression through antisense strategy. We found that inhibition of Id-1 expression suppressed cell proliferation and at the same time induced cellular senescence and G2/M cell-cycle arrest. In addition, inactivation of Id-1 made cells more vulnerable to TGF-β1-induced growth arrest. The sensitization effect on TGF-β1 was associated with up-regulation of two downstream effectors of the TGF-β1 pathway, p21WAF1/Cip1 and p27KIP1. Conclusion. Our results indicate that endogenous Id-1 levels might be a crucial factor in the development of resistance to TGF-β1-induced growth suppression in human prostate epithelial cells.en_HK
dc.languageengen_HK
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.biolcell.org/en_HK
dc.relation.ispartofBiology of the Cellen_HK
dc.subject.meshCell Aging - drug effects - geneticsen_HK
dc.subject.meshCell Division - drug effects - geneticsen_HK
dc.subject.meshCell Line, Transformeden_HK
dc.subject.meshCyclin-Dependent Kinase Inhibitor p21 - genetics - metabolismen_HK
dc.subject.meshEpithelial Cells - cytology - metabolismen_HK
dc.subject.meshG2 Phase - drug effects - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInhibitor of Differentiation Protein 1 - biosynthesis - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshProstate - cytology - metabolismen_HK
dc.subject.meshSignal Transduction - drug effects - geneticsen_HK
dc.subject.meshTransforming Growth Factor beta - metabolism - pharmacologyen_HK
dc.subject.meshTransforming Growth Factor beta1en_HK
dc.subject.meshUp-Regulation - drug effects - geneticsen_HK
dc.titleId-1 modulates senescence and TGF-β1 sensitivity in prostate epithelial cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0248-4900&volume=98&spage=523&epage=533.&date=2006&atitle=Id-1+modulates+senescence+and+TGF-β1+sensitivity+in+prostate+epithelial+cells.+en_HK
dc.identifier.emailLing, MT:patling@hkucc.hku.hken_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityLing, MT=rp00449en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1042/BC20060026en_HK
dc.identifier.pmid16686600-
dc.identifier.scopuseid_2-s2.0-33748647207en_HK
dc.identifier.hkuros133113en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748647207&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume98en_HK
dc.identifier.issue9en_HK
dc.identifier.spage523en_HK
dc.identifier.epage533en_HK
dc.identifier.isiWOS:000240705800002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridDi, K=14526710900en_HK
dc.identifier.scopusauthoridLing, MT=7102229780en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK

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