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Article: Differential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks

TitleDifferential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks
Authors
Keywordsc-Fos
c-Jun
Cognitive memory
Hippocampus
Stimulus-response memory
Striatum
Issue Date2005
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynlme
Citation
Neurobiology Of Learning And Memory, 2005, v. 84 n. 2, p. 75-84 How to Cite?
AbstractResearch examining the neuroanatomical bases of memory in mammals suggests that the hippocampus and dorsal striatum are parts of independent memory systems that mediate "cognitive" and stimulus-response "habit" memory, respectively. At the molecular level, increasing evidence indicates a role for immediate early gene (IEG) expression in memory formation. The present experiment examined whether acquisition of cognitive and habit memory result in differential patterns of IEG protein product expression in these two brain structures. Adult male Long-Evans rats were trained in either a hippocampal-dependent spatial water maze task, or a dorsal striatal-dependent cued water maze task. Ninety minutes after task acquisition, brains were removed and processed for immunocytochemical procedures, and the number of cells expressing Fos-like immunoreactivity (Fos-like-IR) and c-Jun-IR in sections from the dorsal hippocampus and the dorsal striatum were counted. In the dorsal hippocampus of rats trained in the spatial task, there were significantly more c-Jun-IR pyramidal cells in the CA1 and CA3 regions, relative to rats that had acquired the cued task, yoked controls (free-swim), or naïve (home cage) rats. Relative to rats receiving cued task training and control conditions, increases in Fos-like IR were also observed in the CA1 region of rats trained in the spatial task. In rats that had acquired the cued task, patches of c-Jun-IR were observed in the posteroventral striatum; no such patches were evident in rats trained in the spatial task, yoked-control rats, or naïve rats. The results demonstrate that IEG protein product expression is up-regulated in a task-dependent and brain structure-specific manner shortly after acquisition of cognitive and habit memory tasks. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67835
ISSN
2015 Impact Factor: 3.439
2015 SCImago Journal Rankings: 1.940
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTeather, LAen_HK
dc.contributor.authorPackard, MGen_HK
dc.contributor.authorSmith, DEen_HK
dc.contributor.authorEllisBehnke, RGen_HK
dc.contributor.authorBazan, NGen_HK
dc.date.accessioned2010-09-06T05:58:41Z-
dc.date.available2010-09-06T05:58:41Z-
dc.date.issued2005en_HK
dc.identifier.citationNeurobiology Of Learning And Memory, 2005, v. 84 n. 2, p. 75-84en_HK
dc.identifier.issn1074-7427en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67835-
dc.description.abstractResearch examining the neuroanatomical bases of memory in mammals suggests that the hippocampus and dorsal striatum are parts of independent memory systems that mediate "cognitive" and stimulus-response "habit" memory, respectively. At the molecular level, increasing evidence indicates a role for immediate early gene (IEG) expression in memory formation. The present experiment examined whether acquisition of cognitive and habit memory result in differential patterns of IEG protein product expression in these two brain structures. Adult male Long-Evans rats were trained in either a hippocampal-dependent spatial water maze task, or a dorsal striatal-dependent cued water maze task. Ninety minutes after task acquisition, brains were removed and processed for immunocytochemical procedures, and the number of cells expressing Fos-like immunoreactivity (Fos-like-IR) and c-Jun-IR in sections from the dorsal hippocampus and the dorsal striatum were counted. In the dorsal hippocampus of rats trained in the spatial task, there were significantly more c-Jun-IR pyramidal cells in the CA1 and CA3 regions, relative to rats that had acquired the cued task, yoked controls (free-swim), or naïve (home cage) rats. Relative to rats receiving cued task training and control conditions, increases in Fos-like IR were also observed in the CA1 region of rats trained in the spatial task. In rats that had acquired the cued task, patches of c-Jun-IR were observed in the posteroventral striatum; no such patches were evident in rats trained in the spatial task, yoked-control rats, or naïve rats. The results demonstrate that IEG protein product expression is up-regulated in a task-dependent and brain structure-specific manner shortly after acquisition of cognitive and habit memory tasks. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynlmeen_HK
dc.relation.ispartofNeurobiology of Learning and Memoryen_HK
dc.subjectc-Fosen_HK
dc.subjectc-Junen_HK
dc.subjectCognitive memoryen_HK
dc.subjectHippocampusen_HK
dc.subjectStimulus-response memoryen_HK
dc.subjectStriatumen_HK
dc.titleDifferential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasksen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1074-7427&volume=84&spage=75&epage=84&date=2005&atitle=Differential+induction+of+c-JUN+and+Fos-like+proteins+in+rat+hippocampus+and+dorsal+striatum+after+training+in+two+water+maze+tasksen_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.nlm.2005.03.006en_HK
dc.identifier.pmid15936959-
dc.identifier.scopuseid_2-s2.0-23744439526en_HK
dc.identifier.hkuros112788en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-23744439526&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume84en_HK
dc.identifier.issue2en_HK
dc.identifier.spage75en_HK
dc.identifier.epage84en_HK
dc.identifier.isiWOS:000231491600001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001026629-
dc.identifier.scopusauthoridTeather, LA=6602829059en_HK
dc.identifier.scopusauthoridPackard, MG=7006702993en_HK
dc.identifier.scopusauthoridSmith, DE=8548055000en_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK
dc.identifier.scopusauthoridBazan, NG=35450231900en_HK

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