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Article: Mechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cells

TitleMechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cells
Authors
Issue Date2001
PublisherInternational Institute of Anticancer Research.
Citation
Anticancer Research, 2001, v. 21 n. 1 A, p. 403-408 How to Cite?
AbstractCisplatin is used in the treatment of many tumours, including nasopharyngeal carcinoma (NPC). In this study, we studied two nasopharyngeal cancer cell lines with a four-fold difference in sensitivity to cisplatin. Following exposure to cisplatin, the sensitive SUNE1 cell line underwent apoptosis while the relatively resistant CNE1 line died through mitotic cell death. No differences were seen in telomere length or in the cell cycle distribution after cisplatin treatment. However, there was an increase in Bax levels in the sensitive cell line SUNE1, while in the resistant line CNE1 that did not undergo apoptosis, Bax levels fell. Our results suggest that upregulation of Bax is associated with the sensitivity of these NPC cells to cisplatin.
Persistent Identifierhttp://hdl.handle.net/10722/67821
ISSN
2014 Impact Factor: 1.826
2013 SCImago Journal Rankings: 0.812
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Xen_HK
dc.contributor.authorMasters, JRWen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorLo, AKFen_HK
dc.contributor.authorTsao, SWen_HK
dc.date.accessioned2010-09-06T05:58:33Z-
dc.date.available2010-09-06T05:58:33Z-
dc.date.issued2001en_HK
dc.identifier.citationAnticancer Research, 2001, v. 21 n. 1 A, p. 403-408en_HK
dc.identifier.issn0250-7005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67821-
dc.description.abstractCisplatin is used in the treatment of many tumours, including nasopharyngeal carcinoma (NPC). In this study, we studied two nasopharyngeal cancer cell lines with a four-fold difference in sensitivity to cisplatin. Following exposure to cisplatin, the sensitive SUNE1 cell line underwent apoptosis while the relatively resistant CNE1 line died through mitotic cell death. No differences were seen in telomere length or in the cell cycle distribution after cisplatin treatment. However, there was an increase in Bax levels in the sensitive cell line SUNE1, while in the resistant line CNE1 that did not undergo apoptosis, Bax levels fell. Our results suggest that upregulation of Bax is associated with the sensitivity of these NPC cells to cisplatin.en_HK
dc.languageengen_HK
dc.publisherInternational Institute of Anticancer Research.en_HK
dc.relation.ispartofAnticancer Researchen_HK
dc.subject.meshAntineoplastic Agents - pharmacologyen_HK
dc.subject.meshApoptosis - drug effectsen_HK
dc.subject.meshCarcinoma - drug therapy - metabolism - pathologyen_HK
dc.subject.meshCell Cycle - drug effectsen_HK
dc.subject.meshCell Nucleus - ultrastructureen_HK
dc.subject.meshCisplatin - pharmacologyen_HK
dc.subject.meshDrug Resistance, Neoplasmen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKineticsen_HK
dc.subject.meshNasopharyngeal Neoplasms - drug therapy - metabolism - pathologyen_HK
dc.subject.meshProto-Oncogene Proteins - metabolismen_HK
dc.subject.meshProto-Oncogene Proteins c-bcl-2 - metabolismen_HK
dc.subject.meshRadiation-Sensitizing Agents - pharmacologyen_HK
dc.subject.meshTelomere - ultrastructureen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.subject.meshTumor Stem Cell Assayen_HK
dc.subject.meshUp-Regulationen_HK
dc.subject.meshbcl-2-Associated X Proteinen_HK
dc.titleMechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0250-7005&volume=21&spage=403&epage=408&date=2001&atitle=Mechanism+of+differential+sensitivity+to+cisplatin+in+nasopharyngeal+carcinoma+cellsen_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11299769en_HK
dc.identifier.scopuseid_2-s2.0-0035056857en_HK
dc.identifier.hkuros56940en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035056857&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue1 Aen_HK
dc.identifier.spage403en_HK
dc.identifier.epage408en_HK
dc.identifier.isiWOS:000167875900058-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridMasters, JRW=7103071990en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridLo, AKF=7102780657en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK

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