Article: Mechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cells

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TitleMechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cells
AuthorsWang, X1
Masters, JRW1
Wong, YC1
Lo, AKF1
Tsao, SW1
Issue Date2001
PublisherInternational Institute of Anticancer Research.
CitationAnticancer Research, 2001, v. 21 n. 1 A, p. 403-408 [How to Cite?]
AbstractCisplatin is used in the treatment of many tumours, including nasopharyngeal carcinoma (NPC). In this study, we studied two nasopharyngeal cancer cell lines with a four-fold difference in sensitivity to cisplatin. Following exposure to cisplatin, the sensitive SUNE1 cell line underwent apoptosis while the relatively resistant CNE1 line died through mitotic cell death. No differences were seen in telomere length or in the cell cycle distribution after cisplatin treatment. However, there was an increase in Bax levels in the sensitive cell line SUNE1, while in the resistant line CNE1 that did not undergo apoptosis, Bax levels fell. Our results suggest that upregulation of Bax is associated with the sensitivity of these NPC cells to cisplatin.
ISSN0250-7005
2011 Impact Factor: 1.725
2011 SCImago Journal Rankings: 0.176
ISI Accession Number IDWOS:000167875900058
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWang, X
dc.contributor.authorMasters, JRW
dc.contributor.authorWong, YC
dc.contributor.authorLo, AKF
dc.contributor.authorTsao, SW
dc.date.accessioned2010-09-06T05:58:33Z
dc.date.available2010-09-06T05:58:33Z
dc.date.issued2001
dc.description.abstractCisplatin is used in the treatment of many tumours, including nasopharyngeal carcinoma (NPC). In this study, we studied two nasopharyngeal cancer cell lines with a four-fold difference in sensitivity to cisplatin. Following exposure to cisplatin, the sensitive SUNE1 cell line underwent apoptosis while the relatively resistant CNE1 line died through mitotic cell death. No differences were seen in telomere length or in the cell cycle distribution after cisplatin treatment. However, there was an increase in Bax levels in the sensitive cell line SUNE1, while in the resistant line CNE1 that did not undergo apoptosis, Bax levels fell. Our results suggest that upregulation of Bax is associated with the sensitivity of these NPC cells to cisplatin.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAnticancer Research, 2001, v. 21 n. 1 A, p. 403-408 [How to Cite?]
dc.identifier.epage408
dc.identifier.hkuros56940
dc.identifier.isiWOS:000167875900058
dc.identifier.issn0250-7005
2011 Impact Factor: 1.725
2011 SCImago Journal Rankings: 0.176
dc.identifier.issue1 A
dc.identifier.openurl
dc.identifier.pmid11299769
dc.identifier.scopuseid_2-s2.0-0035056857
dc.identifier.spage403
dc.identifier.urihttp://hdl.handle.net/10722/67821
dc.identifier.volume21
dc.languageeng
dc.publisherInternational Institute of Anticancer Research.
dc.publisher.placeGreece
dc.relation.ispartofAnticancer Research
dc.relation.referencesReferences in Scopus
dc.subject.meshAntineoplastic Agents - pharmacology
dc.subject.meshApoptosis - drug effects
dc.subject.meshCarcinoma - drug therapy - metabolism - pathology
dc.subject.meshCell Cycle - drug effects
dc.subject.meshCell Nucleus - ultrastructure
dc.subject.meshCisplatin - pharmacology
dc.subject.meshDrug Resistance, Neoplasm
dc.subject.meshHumans
dc.subject.meshKinetics
dc.subject.meshNasopharyngeal Neoplasms - drug therapy - metabolism - pathology
dc.subject.meshProto-Oncogene Proteins - metabolism
dc.subject.meshProto-Oncogene Proteins c-bcl-2 - metabolism
dc.subject.meshRadiation-Sensitizing Agents - pharmacology
dc.subject.meshTelomere - ultrastructure
dc.subject.meshTumor Cells, Cultured
dc.subject.meshTumor Stem Cell Assay
dc.subject.meshUp-Regulation
dc.subject.meshbcl-2-Associated X Protein
dc.titleMechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cells
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong