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Article: CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters

TitleCNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters
Authors
Issue Date1999
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 1999, v. 40 n. 3, p. 760-766 How to Cite?
AbstractPURPOSE. To investigate the in vivo effects of trophic factors on the axonal regeneration of axotomized retinal ganglion cells in adult hamsters. METHODS. The left optic nerve was transected intracranially or intraorbitally, and a peripheral nerve graft was apposed or sutured to the axotomized optic nerve to enhance regeneration. Trophic factors were applied intravitreally every 5 days. Animals were allowed to survive for 3 or 4 weeks. Regenerating retinal ganglion cells (RGCs) were labeled by applying the dye Fluoro-Gold to the distal end of the peripheral nerve graft 3 days before the animals were killed. RESULTS. Intravitreal application of ciliary neurotrophic factor substantially enhanced the regeneration of damaged axons into a sciatic nerve graft in both experimental conditions (intracranial and intraorbital optic nerve transections) but did not increase the survival of distally axotomized RGCs. Basic fibroblast growth factor and neurotrophins such as nerve growth factor, brain-derived neurotrophic factor, neurotrophin- 3, and neurotrophin-4/5 failed to enhance axonal regeneration of distally axotomized RGCs. CONCLUSIONS. Neurons of the adult central nervous system can regenerate in response to trophic supply after injury, and ciliary neurotrophic factor is at least one of the trophic factors that can promote axonal regeneration of axotomized RGCs.
Persistent Identifierhttp://hdl.handle.net/10722/67807
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCui, Qen_HK
dc.contributor.authorLu, Qen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorYip, HKen_HK
dc.date.accessioned2010-09-06T05:58:25Z-
dc.date.available2010-09-06T05:58:25Z-
dc.date.issued1999en_HK
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 1999, v. 40 n. 3, p. 760-766en_HK
dc.identifier.issn0146-0404en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67807-
dc.description.abstractPURPOSE. To investigate the in vivo effects of trophic factors on the axonal regeneration of axotomized retinal ganglion cells in adult hamsters. METHODS. The left optic nerve was transected intracranially or intraorbitally, and a peripheral nerve graft was apposed or sutured to the axotomized optic nerve to enhance regeneration. Trophic factors were applied intravitreally every 5 days. Animals were allowed to survive for 3 or 4 weeks. Regenerating retinal ganglion cells (RGCs) were labeled by applying the dye Fluoro-Gold to the distal end of the peripheral nerve graft 3 days before the animals were killed. RESULTS. Intravitreal application of ciliary neurotrophic factor substantially enhanced the regeneration of damaged axons into a sciatic nerve graft in both experimental conditions (intracranial and intraorbital optic nerve transections) but did not increase the survival of distally axotomized RGCs. Basic fibroblast growth factor and neurotrophins such as nerve growth factor, brain-derived neurotrophic factor, neurotrophin- 3, and neurotrophin-4/5 failed to enhance axonal regeneration of distally axotomized RGCs. CONCLUSIONS. Neurons of the adult central nervous system can regenerate in response to trophic supply after injury, and ciliary neurotrophic factor is at least one of the trophic factors that can promote axonal regeneration of axotomized RGCs.en_HK
dc.languageengen_HK
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_HK
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAxons - physiologyen_HK
dc.subject.meshAxotomyen_HK
dc.subject.meshCell Survivalen_HK
dc.subject.meshCiliary Neurotrophic Factoren_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshFibroblast Growth Factor 2 - pharmacologyen_HK
dc.subject.meshFluorescent Dyesen_HK
dc.subject.meshInjectionsen_HK
dc.subject.meshMesocricetusen_HK
dc.subject.meshNerve Growth Factors - pharmacologyen_HK
dc.subject.meshNerve Regeneration - drug effectsen_HK
dc.subject.meshNerve Tissue Proteins - pharmacologyen_HK
dc.subject.meshOptic Nerve - physiology - surgeryen_HK
dc.subject.meshRetinal Ganglion Cells - drug effects - physiologyen_HK
dc.subject.meshStilbamidinesen_HK
dc.subject.meshVitreous Body - drug effectsen_HK
dc.titleCNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamstersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0146-0404&volume=40&issue=3&spage=760&epage=766&date=1999&atitle=CNTF,+not+other+trophic+factors,+promotes+axonal+regeneration+of+axotomized+retinal+ganglion+cells+in+adult+hamstersen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid10067981en_HK
dc.identifier.scopuseid_2-s2.0-0006535184en_HK
dc.identifier.hkuros46124en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0006535184&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue3en_HK
dc.identifier.spage760en_HK
dc.identifier.epage766en_HK
dc.identifier.isiWOS:000078849200026-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCui, Q=7103080164en_HK
dc.identifier.scopusauthoridLu, Q=54902894100en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK

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