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Article: Induction of apoptosis by hexamethylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation.

TitleInduction of apoptosis by hexamethylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation.
Authors
Issue Date2000
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/
Citation
International Journal Of Oncology, 2000, v. 16 n. 5, p. 887-892 How to Cite?
AbstractThe present study investigated the relationships amongst apoptosis, terminal differentiation and telomerase activity in human colon carcinoma cells. We found that hexamethylene bisacetamide (HMBA) induced apoptosis in human colon carcinoma LoVo cells harbouring wild-type p53 but not in SW1116 cells harbouring mutant p53. HMBA reduced telomerase activity in both colon carcinoma cells but it did not induce differentiation in the colon carcinoma cells. Taken together, our results suggest that HMBA can induce apoptosis via a p53-dependent pathway, but apoptosis and terminal differentiation may be separately regulated in LoVo cells. Inhibition of telomerase activity may activate apoptosis through a p53-dependent mechanism.
Persistent Identifierhttp://hdl.handle.net/10722/67806
ISSN
2015 Impact Factor: 3.018
2015 SCImago Journal Rankings: 1.270
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorLiong, ECen_HK
dc.contributor.authorLau, TYen_HK
dc.contributor.authorLeung, KMen_HK
dc.contributor.authorFung, PCen_HK
dc.contributor.authorTipoe, GLen_HK
dc.date.accessioned2010-09-06T05:58:25Z-
dc.date.available2010-09-06T05:58:25Z-
dc.date.issued2000en_HK
dc.identifier.citationInternational Journal Of Oncology, 2000, v. 16 n. 5, p. 887-892en_HK
dc.identifier.issn1019-6439en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67806-
dc.description.abstractThe present study investigated the relationships amongst apoptosis, terminal differentiation and telomerase activity in human colon carcinoma cells. We found that hexamethylene bisacetamide (HMBA) induced apoptosis in human colon carcinoma LoVo cells harbouring wild-type p53 but not in SW1116 cells harbouring mutant p53. HMBA reduced telomerase activity in both colon carcinoma cells but it did not induce differentiation in the colon carcinoma cells. Taken together, our results suggest that HMBA can induce apoptosis via a p53-dependent pathway, but apoptosis and terminal differentiation may be separately regulated in LoVo cells. Inhibition of telomerase activity may activate apoptosis through a p53-dependent mechanism.en_HK
dc.languageengen_HK
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/en_HK
dc.relation.ispartofInternational journal of oncologyen_HK
dc.subject.meshAcetamides - pharmacology-
dc.subject.meshAntineoplastic Agents - pharmacology-
dc.subject.meshApoptosis - drug effects-
dc.subject.meshColonic Neoplasms - enzymology - pathology-
dc.subject.meshTelomerase - metabolism-
dc.titleInduction of apoptosis by hexamethylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1019-6439&volume=16&issue=5&spage=887&epage=892&date=2000&atitle=Induction+of+apoptosis+by+hexamethylene+bisacetamide+is+p53-dependent+associated+with+telomerase+activity+but+not+with+terminal+differentiationen_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10762623-
dc.identifier.scopuseid_2-s2.0-0034181980en_HK
dc.identifier.hkuros74739en_HK
dc.identifier.volume16en_HK
dc.identifier.issue5en_HK
dc.identifier.spage887en_HK
dc.identifier.epage892en_HK
dc.identifier.isiWOS:000086570700003-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridZhang, Z=8560559600en_HK
dc.identifier.scopusauthoridLiong, EC=6602732210en_HK
dc.identifier.scopusauthoridLau, TY=26323763000en_HK
dc.identifier.scopusauthoridLeung, KM=7401860685en_HK
dc.identifier.scopusauthoridFung, PC=7101613315en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK

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