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Article: Synergistic effect of optic and peripheral nerve grafts on sprouting of axon-like processes of axotomized retinal ganglion cells in adult hamsters

TitleSynergistic effect of optic and peripheral nerve grafts on sprouting of axon-like processes of axotomized retinal ganglion cells in adult hamsters
Authors
KeywordsAxon-like processes
Optic nerve
Peripheral nerve
Retina
Silver staining
Transplantation
Issue Date1999
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1999, v. 265 n. 3, p. 175-178 How to Cite?
AbstractWe investigated the sprouting response of retinal ganglion cells (RGCs) following the transplantation of peripheral nerve (PN) and/or optic nerve (ON) into the vitreous of the eye and the intraorbital transection of the optic nerve in hamsters. Our previous results showed that an intravitreal PN graft could induce sprouting of axon-like processes in axotomized RGCS [3] (Cho, E.Y. and So, K.F., Characterization of the sprouting response of axon- like processes from retinal ganglion cells after axotomy in adult hamsters: a model using intravitreal implantation of a peripheral nerve, J. Neurocytol., 21 (1992) 589-603). In this model, we have examined the effect of intravitreal ON graft on the sprouting of RGCs both following a co- transplantation of PN and ON into the vitreous and transplantation of ON alone. The present results show that sprouting is increased by more than two- fold in retinas having PN and ON grafts than a PN graft alone. However, the ON graft by itself rarely induced sprouting in RGCs. These results suggest that the ON graft enhance the number of RGCs to sprout axon-like processes in the presence of PN graft by exerting a synergistic rather than an additive effect, since ON graft alone did not induce sprouting. In addition, no diffusible inhibitory effect of ON graft on PN induced sprouting was observed.
Persistent Identifierhttp://hdl.handle.net/10722/67797
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCho, KSen_HK
dc.contributor.authorXiao, YMen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorDiao, YCen_HK
dc.contributor.authorChung, SKen_HK
dc.date.accessioned2010-09-06T05:58:20Z-
dc.date.available2010-09-06T05:58:20Z-
dc.date.issued1999en_HK
dc.identifier.citationNeuroscience Letters, 1999, v. 265 n. 3, p. 175-178en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67797-
dc.description.abstractWe investigated the sprouting response of retinal ganglion cells (RGCs) following the transplantation of peripheral nerve (PN) and/or optic nerve (ON) into the vitreous of the eye and the intraorbital transection of the optic nerve in hamsters. Our previous results showed that an intravitreal PN graft could induce sprouting of axon-like processes in axotomized RGCS [3] (Cho, E.Y. and So, K.F., Characterization of the sprouting response of axon- like processes from retinal ganglion cells after axotomy in adult hamsters: a model using intravitreal implantation of a peripheral nerve, J. Neurocytol., 21 (1992) 589-603). In this model, we have examined the effect of intravitreal ON graft on the sprouting of RGCs both following a co- transplantation of PN and ON into the vitreous and transplantation of ON alone. The present results show that sprouting is increased by more than two- fold in retinas having PN and ON grafts than a PN graft alone. However, the ON graft by itself rarely induced sprouting in RGCs. These results suggest that the ON graft enhance the number of RGCs to sprout axon-like processes in the presence of PN graft by exerting a synergistic rather than an additive effect, since ON graft alone did not induce sprouting. In addition, no diffusible inhibitory effect of ON graft on PN induced sprouting was observed.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAxon-like processesen_HK
dc.subjectOptic nerveen_HK
dc.subjectPeripheral nerveen_HK
dc.subjectRetinaen_HK
dc.subjectSilver stainingen_HK
dc.subjectTransplantationen_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAxons - physiologyen_HK
dc.subject.meshAxotomyen_HK
dc.subject.meshCell Division - physiologyen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshOptic Nerve - cytology - transplantationen_HK
dc.subject.meshPeroneal Nerve - cytology - transplantationen_HK
dc.subject.meshRetinal Ganglion Cells - transplantation - ultrastructureen_HK
dc.subject.meshSilver Stainingen_HK
dc.titleSynergistic effect of optic and peripheral nerve grafts on sprouting of axon-like processes of axotomized retinal ganglion cells in adult hamstersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=265&spage=175&epage=178&date=1999&atitle=Synergistic+effect+of+optic+and+peripheral+nerve+grafts+on+sprouting+of+axon-like+processes+of+axotomized+retinal+ganglion+cells+in+adult+hamstersen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChung, SK:skchung@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChung, SK=rp00381en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0304-3940(99)00240-2en_HK
dc.identifier.pmid10327159-
dc.identifier.scopuseid_2-s2.0-0033597304en_HK
dc.identifier.hkuros40782en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033597304&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume265en_HK
dc.identifier.issue3en_HK
dc.identifier.spage175en_HK
dc.identifier.epage178en_HK
dc.identifier.isiWOS:000080020100007-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridCho, KS=7403956958en_HK
dc.identifier.scopusauthoridXiao, YM=7403260801en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridDiao, YC=7004284577en_HK
dc.identifier.scopusauthoridChung, SK=7404292976en_HK

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