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Article: New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway

TitleNew polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway
Authors
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2007, v. 1153 n. 1, p. 221-230 How to Cite?
AbstractMost of the polysaccharides purified from Chinese medicinal herbs showed anti-tumor and immune-stimulating effects. However, little is known about their effects on neuroprotection. Our previous study has demonstrated that polysaccharides (J2, J3 and J4) isolated from the flowers of Nerium indicum (Oleander) exert partial protection in cortical neurons stressed by beta-amyloid (Aβ) peptides or deprivation of nutrition from serum. In this study, we have isolated and characterized a new polysaccharide from the flowers of N. indicum (named as J6) and aimed to investigate its neuroprotective effects against Aβ-induced apoptosis. Pretreatment of the polysaccharide J6 significantly decreased the activity of caspase-3 as well as the cytotoxicity triggered by Aβ peptides in a dose-dependent manner. In contrast to the activation of survival signaling such as Akt found in J2, J3 and J4 fractions, neuroprotective effects of J6 markedly inhibited Aβ peptide-stimulated phosphorylation of c-Jun N-terminal kinase (JNK-1) as determined by Western blot analysis. Taken together, the polysaccharide J6 isolated from the flowers of N. indicum can serve as potential neuroprotective agent against neuronal death in Alzheimer's disease and the neuroprotective mechanism may primarily rely on inactivation of JNK signaling pathway. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67796
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, MSen_HK
dc.contributor.authorWong, AYYen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorFang, JNen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-06T05:58:20Z-
dc.date.available2010-09-06T05:58:20Z-
dc.date.issued2007en_HK
dc.identifier.citationBrain Research, 2007, v. 1153 n. 1, p. 221-230en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67796-
dc.description.abstractMost of the polysaccharides purified from Chinese medicinal herbs showed anti-tumor and immune-stimulating effects. However, little is known about their effects on neuroprotection. Our previous study has demonstrated that polysaccharides (J2, J3 and J4) isolated from the flowers of Nerium indicum (Oleander) exert partial protection in cortical neurons stressed by beta-amyloid (Aβ) peptides or deprivation of nutrition from serum. In this study, we have isolated and characterized a new polysaccharide from the flowers of N. indicum (named as J6) and aimed to investigate its neuroprotective effects against Aβ-induced apoptosis. Pretreatment of the polysaccharide J6 significantly decreased the activity of caspase-3 as well as the cytotoxicity triggered by Aβ peptides in a dose-dependent manner. In contrast to the activation of survival signaling such as Akt found in J2, J3 and J4 fractions, neuroprotective effects of J6 markedly inhibited Aβ peptide-stimulated phosphorylation of c-Jun N-terminal kinase (JNK-1) as determined by Western blot analysis. Taken together, the polysaccharide J6 isolated from the flowers of N. indicum can serve as potential neuroprotective agent against neuronal death in Alzheimer's disease and the neuroprotective mechanism may primarily rely on inactivation of JNK signaling pathway. © 2007 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.rightsBrain Research. Copyright © Elsevier BV.en_HK
dc.subject.meshAmyloid beta-Peptides - toxicityen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCaspase 3 - metabolismen_HK
dc.subject.meshCerebral Cortex - cytologyen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshDrug Interactionsen_HK
dc.subject.meshEmbryo, Mammalianen_HK
dc.subject.meshIndoles - diagnostic useen_HK
dc.subject.meshL-Lactate Dehydrogenase - metabolismen_HK
dc.subject.meshMitogen-Activated Protein Kinases - metabolismen_HK
dc.subject.meshNerium - chemistryen_HK
dc.subject.meshNeurons - drug effectsen_HK
dc.subject.meshPlant Structures - chemistryen_HK
dc.subject.meshPolysaccharides - pharmacologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSignal Transduction - drug effectsen_HK
dc.titleNew polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathwayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=1153&spage=221&epage=230&date=2007&atitle=New+polysaccharide+from+Nerium+indicum+protects+neurons+via+stress+kinase+signaling+pathwayen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.brainres.2007.03.074en_HK
dc.identifier.pmid17475226-
dc.identifier.scopuseid_2-s2.0-34249335693en_HK
dc.identifier.hkuros127848en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249335693&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1153en_HK
dc.identifier.issue1en_HK
dc.identifier.spage221en_HK
dc.identifier.epage230en_HK
dc.identifier.isiWOS:000247423800025-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridYu, MS=35346047600en_HK
dc.identifier.scopusauthoridWong, AYY=35081505000en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridFang, JN=7402963759en_HK
dc.identifier.scopusauthoridYuen, WH=7102761282en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK

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