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Article: Morphological plasticity of axotomized retinal ganglion cells following intravitreal transplantation of a peripheral nerve segment

TitleMorphological plasticity of axotomized retinal ganglion cells following intravitreal transplantation of a peripheral nerve segment
Authors
Issue Date1995
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-4864
Citation
Journal Of Neurocytology, 1995, v. 24 n. 7, p. 497-506 How to Cite?
AbstractDuring normal development of retinal ganglion cells when the axons are growing, transient dendritic spines have been observed. Similar dendritic spine-like processes are also exhibited by retinal ganglion cells undergoing axonal regeneration into a peripheral nerve grafted to the damaged optic axons. Here we show, using the intracellular injection of Lucifer Yellow, than when a segment of peripheral nerve is transplanted to the vitreous body, a procedure which induces ectopic sprouting of axon-like processes from the cell bodies and dendrites of some retinal ganglion cells, similar spine-like processes appear on the dendrites of cells with ectopic sprouts. Quantitative analysis indicated that there were significant changes with post-transplantation survival time in the distributions of spine-like processes and axon-like processes on these sprouting retinal ganglion cells following the intravitreal transplantation of a piece of peripheral nerve. The remodelling of the spine-like processes and axon-like processes correlated with one another suggesting that plastic changes can occur in certain dendritic subcompartments independent of the growth activity of the other dendritic subcompartments.
Persistent Identifierhttp://hdl.handle.net/10722/67791
ISSN
2007 Impact Factor: 1.935
2009 SCImago Journal Rankings: 0.911
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLei, JLen_HK
dc.contributor.authorLau, KCen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorCho, EYPen_HK
dc.contributor.authorTay, Den_HK
dc.date.accessioned2010-09-06T05:58:17Z-
dc.date.available2010-09-06T05:58:17Z-
dc.date.issued1995en_HK
dc.identifier.citationJournal Of Neurocytology, 1995, v. 24 n. 7, p. 497-506en_HK
dc.identifier.issn0300-4864en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67791-
dc.description.abstractDuring normal development of retinal ganglion cells when the axons are growing, transient dendritic spines have been observed. Similar dendritic spine-like processes are also exhibited by retinal ganglion cells undergoing axonal regeneration into a peripheral nerve grafted to the damaged optic axons. Here we show, using the intracellular injection of Lucifer Yellow, than when a segment of peripheral nerve is transplanted to the vitreous body, a procedure which induces ectopic sprouting of axon-like processes from the cell bodies and dendrites of some retinal ganglion cells, similar spine-like processes appear on the dendrites of cells with ectopic sprouts. Quantitative analysis indicated that there were significant changes with post-transplantation survival time in the distributions of spine-like processes and axon-like processes on these sprouting retinal ganglion cells following the intravitreal transplantation of a piece of peripheral nerve. The remodelling of the spine-like processes and axon-like processes correlated with one another suggesting that plastic changes can occur in certain dendritic subcompartments independent of the growth activity of the other dendritic subcompartments.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-4864en_HK
dc.relation.ispartofJournal of Neurocytologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAxonal Transporten_HK
dc.subject.meshAxons - physiology - ultrastructureen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshFluorescent Dyesen_HK
dc.subject.meshIsoquinolinesen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMesocricetusen_HK
dc.subject.meshNerve Regenerationen_HK
dc.subject.meshNeuronal Plasticityen_HK
dc.subject.meshPeroneal Nerve - physiology - transplantationen_HK
dc.subject.meshRetinal Ganglion Cells - cytology - physiologyen_HK
dc.subject.meshTime Factorsen_HK
dc.titleMorphological plasticity of axotomized retinal ganglion cells following intravitreal transplantation of a peripheral nerve segmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-4864&volume=24&spage=497&epage=506&date=1995&atitle=Morphological+plasticity+of+axotomized+retinal+ganglion+cells+following+intravitreal+transplantation+of+a+peripheral+nerve+segmenten_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailTay, D:dkctay@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityTay, D=rp00336en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/BF01179975en_HK
dc.identifier.pmid7561958-
dc.identifier.scopuseid_2-s2.0-0029155543en_HK
dc.identifier.hkuros8484en_HK
dc.identifier.volume24en_HK
dc.identifier.issue7en_HK
dc.identifier.spage497en_HK
dc.identifier.epage506en_HK
dc.identifier.isiWOS:A1995RM21900002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLei, JL=20134828600en_HK
dc.identifier.scopusauthoridLau, KC=16166359000en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridCho, EYP=7202649985en_HK
dc.identifier.scopusauthoridTay, D=7006796825en_HK

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