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Article: Novel neuroprotective effects of the aqueous extracts from Verbena officinalis Linn

TitleNovel neuroprotective effects of the aqueous extracts from Verbena officinalis Linn
Authors
Issue Date2006
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/neuropharm
Citation
Neuropharmacology, 2006, v. 50 n. 6, p. 641-650 How to Cite?
AbstractVerbena officinialis Linn. (Verbenaceae) is a perennial plant which has been used as herbal medicine or health supplement in both Western and Eastern countries for centuries. It has been used to treat acute dysentery, enteritis, amenorrhea and depression. In view of its wide array of biological effects, we hypothesized that V. officinalis can exert cytoprotective effects on cells of the central nervous system. Pre-treatment of aqueous extracts of V. officinalis significantly attenuated the toxicity of β-amyloid (Aβ) peptide and reducing agent dithiothreitol in primary cultures of cortical neurons. As extracellular accumulation of Aβ peptide is an important cytotoxic factor involved in Alzheimer's disease (AD), we have further explored its neuroprotective effect against Aβ. Treatment of V. officinalis attenuated Aβ-triggered DEVD- and VDVAD-cleavage activities in a dose-dependent manner. Further studies elucidated that phosphorylation of both interferon-inducing protein kinase (PKR) and c-Jun N-terminal kinase (JNK) was attenuated in Aβ-treated neurons. Taken together, we have proved our hypothesis by showing the novel neuroprotective effects of V. officinalis. As V. officinalis has long been used for many years to be a folk medicine, our study may provide a lead for its potential to be a neuroprotective agent against neuronal loss in AD. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67790
ISSN
2015 Impact Factor: 4.936
2015 SCImago Journal Rankings: 2.506
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, SWen_HK
dc.contributor.authorYu, MSen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-06T05:58:16Z-
dc.date.available2010-09-06T05:58:16Z-
dc.date.issued2006en_HK
dc.identifier.citationNeuropharmacology, 2006, v. 50 n. 6, p. 641-650en_HK
dc.identifier.issn0028-3908en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67790-
dc.description.abstractVerbena officinialis Linn. (Verbenaceae) is a perennial plant which has been used as herbal medicine or health supplement in both Western and Eastern countries for centuries. It has been used to treat acute dysentery, enteritis, amenorrhea and depression. In view of its wide array of biological effects, we hypothesized that V. officinalis can exert cytoprotective effects on cells of the central nervous system. Pre-treatment of aqueous extracts of V. officinalis significantly attenuated the toxicity of β-amyloid (Aβ) peptide and reducing agent dithiothreitol in primary cultures of cortical neurons. As extracellular accumulation of Aβ peptide is an important cytotoxic factor involved in Alzheimer's disease (AD), we have further explored its neuroprotective effect against Aβ. Treatment of V. officinalis attenuated Aβ-triggered DEVD- and VDVAD-cleavage activities in a dose-dependent manner. Further studies elucidated that phosphorylation of both interferon-inducing protein kinase (PKR) and c-Jun N-terminal kinase (JNK) was attenuated in Aβ-treated neurons. Taken together, we have proved our hypothesis by showing the novel neuroprotective effects of V. officinalis. As V. officinalis has long been used for many years to be a folk medicine, our study may provide a lead for its potential to be a neuroprotective agent against neuronal loss in AD. © 2005 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/neuropharmen_HK
dc.relation.ispartofNeuropharmacologyen_HK
dc.subject.meshAmyloid beta-Peptides - toxicityen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCaspase 3en_HK
dc.subject.meshCaspases - metabolismen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshCerebral Cortex - cytologyen_HK
dc.subject.meshDDT - toxicityen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshDrug Interactionsen_HK
dc.subject.meshEmbryo, Mammalianen_HK
dc.subject.meshIndoles - diagnostic useen_HK
dc.subject.meshInterferons - pharmacologyen_HK
dc.subject.meshMAP Kinase Kinase 4 - metabolismen_HK
dc.subject.meshNeurons - cytology - drug effectsen_HK
dc.subject.meshNeuroprotective Agents - chemistry - isolation & purification - pharmacologyen_HK
dc.subject.meshPeptide Fragments - toxicityen_HK
dc.subject.meshPhosphorylation - drug effectsen_HK
dc.subject.meshPlant Extracts - chemistry - isolation & purification - pharmacologyen_HK
dc.subject.meshProtein Kinases - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshVerbena - chemistryen_HK
dc.titleNovel neuroprotective effects of the aqueous extracts from Verbena officinalis Linnen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-3908&volume=50&spage=641&epage=650&date=2006&atitle=Novel+neuroprotective+effects+of+the+aqueous+extracts+from+Verbena+officinalis+Linnen_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuropharm.2005.11.009en_HK
dc.identifier.pmid16406021-
dc.identifier.scopuseid_2-s2.0-33646474912en_HK
dc.identifier.hkuros148393en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646474912&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue6en_HK
dc.identifier.spage641en_HK
dc.identifier.epage650en_HK
dc.identifier.isiWOS:000237603800001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLai, SW=8729823700en_HK
dc.identifier.scopusauthoridYu, MS=35346047600en_HK
dc.identifier.scopusauthoridYuen, WH=7102761282en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK

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