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Article: Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion

TitleSignificance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion
Authors
KeywordsBladder cancer
Epidermal growth factor receptor
Inhibitor of differentiation/DNA binding
Invasion
Issue Date2006
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/
Citation
International Journal Of Oncology, 2006, v. 28 n. 4, p. 847-854 How to Cite?
AbstractEpidermal growth factor receptor (EGFR) is suggested to be one of the positive factors in the invasive progression of bladder cancer. Id-1 (inhibitor of differentiation or DNA binding), a helix-loop-helix (HLH) transcription factor, was recently identified as a key factor in the EGFR signalling pathway. The aim of this study was to investigate the role of Id-1 in bladder cancer progression and its relationship with EGFR. Using clinical specimens from different stages of bladder cancer, immunohistochemical staining was performed to determine if Id-1 expression was positively associated with tumour staging and EGFR expression. The direct role of Id-1 in cancer cell invasion was also investigated through ectopically expressing the Id-1 gene in a RT112 bladder cancer cell line by wound closure and collagen invasion assays. To explore the therapeutic potential of targeting the Id-1 gene in the treatment of invasive bladder cancer, we studied if inactivation of the Id-1 gene through small RNA interference could lead to the suppression of invasion in a MGHU1 bladder cancer cell line. Our results showed that the up-regulation of Id-1 was associated with increased EGFR expression, clinical staging and the invasion ability of bladder cancer cells. Inactivation of Id-1 may be a potential therapeutic target to inhibit the invasion by bladder cancer cells.
Persistent Identifierhttp://hdl.handle.net/10722/67788
ISSN
2015 Impact Factor: 3.018
2015 SCImago Journal Rankings: 1.270
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDing, Yen_HK
dc.contributor.authorWang, Gen_HK
dc.contributor.authorLing, MTen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorNa, Yen_HK
dc.contributor.authorZhang, Xen_HK
dc.contributor.authorChua, CWen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorXin, Den_HK
dc.date.accessioned2010-09-06T05:58:15Z-
dc.date.available2010-09-06T05:58:15Z-
dc.date.issued2006en_HK
dc.identifier.citationInternational Journal Of Oncology, 2006, v. 28 n. 4, p. 847-854en_HK
dc.identifier.issn1019-6439en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67788-
dc.description.abstractEpidermal growth factor receptor (EGFR) is suggested to be one of the positive factors in the invasive progression of bladder cancer. Id-1 (inhibitor of differentiation or DNA binding), a helix-loop-helix (HLH) transcription factor, was recently identified as a key factor in the EGFR signalling pathway. The aim of this study was to investigate the role of Id-1 in bladder cancer progression and its relationship with EGFR. Using clinical specimens from different stages of bladder cancer, immunohistochemical staining was performed to determine if Id-1 expression was positively associated with tumour staging and EGFR expression. The direct role of Id-1 in cancer cell invasion was also investigated through ectopically expressing the Id-1 gene in a RT112 bladder cancer cell line by wound closure and collagen invasion assays. To explore the therapeutic potential of targeting the Id-1 gene in the treatment of invasive bladder cancer, we studied if inactivation of the Id-1 gene through small RNA interference could lead to the suppression of invasion in a MGHU1 bladder cancer cell line. Our results showed that the up-regulation of Id-1 was associated with increased EGFR expression, clinical staging and the invasion ability of bladder cancer cells. Inactivation of Id-1 may be a potential therapeutic target to inhibit the invasion by bladder cancer cells.en_HK
dc.languageengen_HK
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/en_HK
dc.relation.ispartofInternational Journal of Oncologyen_HK
dc.subjectBladder canceren_HK
dc.subjectEpidermal growth factor receptoren_HK
dc.subjectInhibitor of differentiation/DNA bindingen_HK
dc.subjectInvasionen_HK
dc.subject.meshInhibitor of Differentiation Protein 1 - analysis - genetics - physiology-
dc.subject.meshGenetic Vectors/genetics-
dc.subject.meshNeoplasm Staging-
dc.subject.meshReceptor, Epidermal Growth Factor - analysis - genetics-
dc.subject.meshUrinary Bladder Neoplasms - genetics - metabolism - pathology-
dc.titleSignificance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1019-6439&volume=28&issue=4&spage=847&epage=854&date=2006&atitle=Significance+of+Id-1+up-regulation+and+its+association+with+EGFR+in+bladder+cancer+cell+invasionen_HK
dc.identifier.emailLing, MT:patling@hkucc.hku.hken_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityLing, MT=rp00449en_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid16525633-
dc.identifier.scopuseid_2-s2.0-33744758656en_HK
dc.identifier.hkuros138226en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33744758656&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue4en_HK
dc.identifier.spage847en_HK
dc.identifier.epage854en_HK
dc.identifier.isiWOS:000236077500008-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridDing, Y=36997788500en_HK
dc.identifier.scopusauthoridWang, G=36683489600en_HK
dc.identifier.scopusauthoridLing, MT=7102229780en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridLi, X=36065691100en_HK
dc.identifier.scopusauthoridNa, Y=7006088519en_HK
dc.identifier.scopusauthoridZhang, X=36683620000en_HK
dc.identifier.scopusauthoridChua, CW=9437494600en_HK
dc.identifier.scopusauthoridWang, X=35335525600en_HK
dc.identifier.scopusauthoridXin, D=7006327751en_HK

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