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Article: Current understandings of the molecular genetics of gestational trophoblastic diseases

TitleCurrent understandings of the molecular genetics of gestational trophoblastic diseases
Authors
Issue Date2002
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/placenta
Citation
Placenta, 2002, v. 23 n. 1, p. 20-31 How to Cite?
AbstractGestational trophoblastic disease (GTD) is a heterogeneous group of diseases characterized by abnormally proliferating trophoblastic tissues. This includes partial and complete hydatidiform moles, invasive mole, choriocarcinoma and placental site trophoblastic tumour. Cytogenetic studies revealed that hydatidiform moles contain either solely (as in complete moles) or an excess (as in partial moles) of paternal contribution to the genome. Genomic imprinting is believed to play a pivotal role in the pathogenesis of hydatidiform moles. However its precise role and mechanism remains poorly understood. Hydatidiform mole carries a potential of malignant transformation. Similar to other human cancers, malignant transformation in gestational trophoblastic tumours is likely a multistep process and involves multiple genetic alterations including activation of oncogenes and inactivation of tumour suppressor genes. In addition, expression of telomerase activity, altered expression of cell-cell adhesion molecules and abnormal expression of matrix metalloproteinases have also been reported in GTD. These represent disruption of the delicate balance and regulation of cellular processes including proliferation, differentiation, apoptosis and invasion. The significance of these alterations in the pathogenesis and malignant transformation of gestational trophoblastic diseases is reviewed in this paper. © 2002 Harcourt Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/67768
ISSN
2015 Impact Factor: 2.972
2015 SCImago Journal Rankings: 1.608
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, HWen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-09-06T05:58:04Z-
dc.date.available2010-09-06T05:58:04Z-
dc.date.issued2002en_HK
dc.identifier.citationPlacenta, 2002, v. 23 n. 1, p. 20-31en_HK
dc.identifier.issn0143-4004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67768-
dc.description.abstractGestational trophoblastic disease (GTD) is a heterogeneous group of diseases characterized by abnormally proliferating trophoblastic tissues. This includes partial and complete hydatidiform moles, invasive mole, choriocarcinoma and placental site trophoblastic tumour. Cytogenetic studies revealed that hydatidiform moles contain either solely (as in complete moles) or an excess (as in partial moles) of paternal contribution to the genome. Genomic imprinting is believed to play a pivotal role in the pathogenesis of hydatidiform moles. However its precise role and mechanism remains poorly understood. Hydatidiform mole carries a potential of malignant transformation. Similar to other human cancers, malignant transformation in gestational trophoblastic tumours is likely a multistep process and involves multiple genetic alterations including activation of oncogenes and inactivation of tumour suppressor genes. In addition, expression of telomerase activity, altered expression of cell-cell adhesion molecules and abnormal expression of matrix metalloproteinases have also been reported in GTD. These represent disruption of the delicate balance and regulation of cellular processes including proliferation, differentiation, apoptosis and invasion. The significance of these alterations in the pathogenesis and malignant transformation of gestational trophoblastic diseases is reviewed in this paper. © 2002 Harcourt Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/placentaen_HK
dc.relation.ispartofPlacentaen_HK
dc.subject.meshAdulten_HK
dc.subject.meshChoriocarcinoma - genetics - pathologyen_HK
dc.subject.meshCytogenetic Analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshGenes, Tumor Suppressoren_HK
dc.subject.meshGenomic Imprintingen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydatidiform Mole, Invasive - genetics - pathologyen_HK
dc.subject.meshMolecular Biologyen_HK
dc.subject.meshOncogenesen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshTelomeraseen_HK
dc.subject.meshTrophoblastic Tumor, Placental Site - genetics - pathologyen_HK
dc.titleCurrent understandings of the molecular genetics of gestational trophoblastic diseasesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0143-4004&volume=23&spage=20&epage=31&date=2002&atitle=Current+understandings+of+the+molecular+genetics+of+gestational+trophoblastic+diseasesen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/plac.2001.0744en_HK
dc.identifier.pmid11869089en_HK
dc.identifier.scopuseid_2-s2.0-0036365324en_HK
dc.identifier.hkuros66831en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036365324&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue1en_HK
dc.identifier.spage20en_HK
dc.identifier.epage31en_HK
dc.identifier.isiWOS:000173654700003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, HW=37085839000en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridCheung, ANY=7401806538en_HK

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