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Article: Age-related reexpression of p75 in axotomized motoneurons

TitleAge-related reexpression of p75 in axotomized motoneurons
Authors
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2006, v. 17 n. 7, p. 711-715 How to Cite?
Abstractp75 was immunohistochemically identified in spinal motoneurons in immature and adult rats after either distal peripheral axotomy or root avulsion. Few or no p75 positive motoneurons were observed after distal axotomy in animals at the age of postnatal day 1 and postnatal day 7, whereas the injury induced marked neuronal death. Motoneurons reexpressed p75 from the end of the second postnatal week to adulthood in response to distal axotomy, whereas most motoneurons survived after the injury. On the other hand, root avulsion in animals of all ages did not cause significant p75 expression in avulsed motoneurons where most motoneurons died ultimately. The potential role of such reexpression in motoneuron protection is discussed. © 2006 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/67759
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Qen_HK
dc.contributor.authorHu, Ben_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-09-06T05:58:00Z-
dc.date.available2010-09-06T05:58:00Z-
dc.date.issued2006en_HK
dc.identifier.citationNeuroreport, 2006, v. 17 n. 7, p. 711-715en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67759-
dc.description.abstractp75 was immunohistochemically identified in spinal motoneurons in immature and adult rats after either distal peripheral axotomy or root avulsion. Few or no p75 positive motoneurons were observed after distal axotomy in animals at the age of postnatal day 1 and postnatal day 7, whereas the injury induced marked neuronal death. Motoneurons reexpressed p75 from the end of the second postnatal week to adulthood in response to distal axotomy, whereas most motoneurons survived after the injury. On the other hand, root avulsion in animals of all ages did not cause significant p75 expression in avulsed motoneurons where most motoneurons died ultimately. The potential role of such reexpression in motoneuron protection is discussed. © 2006 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsNeuroReport. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAging - metabolismen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshAxotomyen_HK
dc.subject.meshCell Count - methodsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Developmental - physiologyen_HK
dc.subject.meshImmunohistochemistry - methodsen_HK
dc.subject.meshMotor Neurons - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReceptor, Nerve Growth Factor - metabolismen_HK
dc.subject.meshSpinal Cord - cytology - metabolismen_HK
dc.subject.meshTime Factorsen_HK
dc.titleAge-related reexpression of p75 in axotomized motoneuronsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4965&volume=17&issue=7&spage=711&epage=715&date=2006&atitle=Age-related+reexpression+of+p75+in+axotomized+motoneuronsen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.wnr.0000214390.35480.1aen_HK
dc.identifier.pmid16641674-
dc.identifier.scopuseid_2-s2.0-33745457974en_HK
dc.identifier.hkuros116528en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745457974&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue7en_HK
dc.identifier.spage711en_HK
dc.identifier.epage715en_HK
dc.identifier.isiWOS:000237875600005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuan, Q=7202814773en_HK
dc.identifier.scopusauthoridHu, B=35733928400en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK

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