File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Article: Exhaled nitric oxide in bronchiectasis: The effects of inhaled corticosteroid therapy

TitleExhaled nitric oxide in bronchiectasis: The effects of inhaled corticosteroid therapy
Authors
KeywordsBronchiectasis
Inhaled corticosteroid therapy
Nitric oxide
Pseudomonas aeruginosa
Issue Date2004
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
Citation
International Journal Of Tuberculosis And Lung Disease, 2004, v. 8 n. 11, p. 1301-1307 How to Cite?
AbstractSETTING: While exhaled nitric oxide (eNO) levels are reduced by inhaled corticosteroid therapy in asthma, such treatment effect is unclear in bronchiectasis. DESIGN: Stable non-smoking bronchiectasis patients were randomised to receive either fluticasone (1 mg/ daily) or identical placebo via the Accuhaler device. RESULTS: Sixty non-smoking patients (38 women; mean age 56.4 ± 12.7 years) were recruited. Of these, half received inhaled fluticasone and half placebo therapy. eNO was measured using a chemiluminescence analyser at 0, 4, 12, 24, 36 and 52 weeks. There was no significant difference in eNO levels between fluticasone and placebo patients over the study period. There was no correlation between baseline eNO with age, FEV1, FVC, 24 h sputum volume or number of bronchiectatic segments. Patients with Pseudomonas aeruginosa (PA) infection, but not their counterparts, displayed a correlation between 0- and 52-week eNO levels. PA infection was associated with significantly lower eNO levels among the patients. CONCLUSIONS: Inhaled fluticasone therapy, despite being an effective anti-inflammatory agent, has no significant effect on eNO production, either at individual time points or over the entire 52-week profile, in bronchiectasis. It appears that eNO might not reflect the extent of airway inflammation in bronchiectasis.
Persistent Identifierhttp://hdl.handle.net/10722/67751
ISSN
2015 Impact Factor: 2.148
2015 SCImago Journal Rankings: 1.381
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorTan, KCen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLeung, Ren_HK
dc.contributor.authorMak, JCen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorKo, Cen_HK
dc.contributor.authorLam, WKen_HK
dc.date.accessioned2010-09-06T05:57:55Z-
dc.date.available2010-09-06T05:57:55Z-
dc.date.issued2004en_HK
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2004, v. 8 n. 11, p. 1301-1307en_HK
dc.identifier.issn1027-3719en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67751-
dc.description.abstractSETTING: While exhaled nitric oxide (eNO) levels are reduced by inhaled corticosteroid therapy in asthma, such treatment effect is unclear in bronchiectasis. DESIGN: Stable non-smoking bronchiectasis patients were randomised to receive either fluticasone (1 mg/ daily) or identical placebo via the Accuhaler device. RESULTS: Sixty non-smoking patients (38 women; mean age 56.4 ± 12.7 years) were recruited. Of these, half received inhaled fluticasone and half placebo therapy. eNO was measured using a chemiluminescence analyser at 0, 4, 12, 24, 36 and 52 weeks. There was no significant difference in eNO levels between fluticasone and placebo patients over the study period. There was no correlation between baseline eNO with age, FEV1, FVC, 24 h sputum volume or number of bronchiectatic segments. Patients with Pseudomonas aeruginosa (PA) infection, but not their counterparts, displayed a correlation between 0- and 52-week eNO levels. PA infection was associated with significantly lower eNO levels among the patients. CONCLUSIONS: Inhaled fluticasone therapy, despite being an effective anti-inflammatory agent, has no significant effect on eNO production, either at individual time points or over the entire 52-week profile, in bronchiectasis. It appears that eNO might not reflect the extent of airway inflammation in bronchiectasis.en_HK
dc.languageengen_HK
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.htmlen_HK
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Diseaseen_HK
dc.subjectBronchiectasisen_HK
dc.subjectInhaled corticosteroid therapyen_HK
dc.subjectNitric oxideen_HK
dc.subjectPseudomonas aeruginosaen_HK
dc.titleExhaled nitric oxide in bronchiectasis: The effects of inhaled corticosteroid therapyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1027-3719&volume=8&issue=11&spage=1301&epage=1307&date=2004&atitle=Exhaled+nitric+oxide+in+bronchiectasis:+the+effects+of+inhaled+corticosteroid+therapyen_HK
dc.identifier.emailTan, KC:kcbtan@hku.hken_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailMak, JC:judymak@hku.hken_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityTan, KC=rp00402en_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityMak, JC=rp00352en_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15581196-
dc.identifier.scopuseid_2-s2.0-10044233022en_HK
dc.identifier.hkuros98979en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10044233022&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1301en_HK
dc.identifier.epage1307en_HK
dc.identifier.isiWOS:000225322900005-
dc.publisher.placeFranceen_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridTan, KC=8082703100en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridLeung, R=7101876102en_HK
dc.identifier.scopusauthoridMak, JC=7103323094en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridKo, C=8728540600en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats