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Article: Endothelin-1 in stable bronchiectasis

TitleEndothelin-1 in stable bronchiectasis
Authors
KeywordsBronchiectasis
Cytokines
Endothelin-1
Sputum
Issue Date2000
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2000, v. 16 n. 1, p. 146-149 How to Cite?
AbstractEndothelin (ET)-1 has been suggested to promote neutrophil adhesion to endothelium, migration to inflamed areas, and release of elastase. ET-1 might therefore play a role in the pathogenesis of bronchiectasis, a chronic inflammatory and infective airway disease which is still poorly understood. Thirty five patients with stable bronchiectasis (20 females, mean age±SD 49.1±15.0 yrs) and 18 control subjects (8 females, 49.4±11.3 yrs) were recruited prospectively. The ET-1 levels in serum and sputum were measured by commercially available enzyme linked immunosorbent assay (ELISA) kits. Patients with Pseudomonas aeruginosa in their sputum had a significantly higher serum level of ET-1 (median 25.8, interquartile range 13-43.9 pg · mL -1) than patients without P. aeruginosa (0, 0-10.5 pg · mL -1; p=0.0004) and healthy control subjects (4.6, 0-16.3 pg · mL -1; p=0.002). However, patients with and without P. aeruginosa infection had no significant difference in sputum ET-1 level (p=0.15). There was no correlation between serum or sputum ET-1 levels with the serum and sputum levels of the interleukin (IL)-1β, IL-8 and tumour necrosis factor (TNF)-α; the number of bronchiectasis lung lobes; and spirometry. Serum ET-1 level correlated with 24 h sputum volume for the bronchiectasis patients (r=0.51, p=0.002). The results, therefore, suggest a significant pathogenic role for endothelin-1 among Pseudomonas aeruginosa-infected patients with bronchiectasis. Further studies should be performed to evaluate the clinico-pathological correlation and expression of endothelin-1 in bronchiectasis. (C)ERS Journals Ltd 2000.
Persistent Identifierhttp://hdl.handle.net/10722/67748
ISSN
2015 Impact Factor: 8.332
2015 SCImago Journal Rankings: 3.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, Len_HK
dc.contributor.authorTipoe, Gen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorHo, JCMen_HK
dc.contributor.authorShum, Ien_HK
dc.contributor.authorOoi, GGen_HK
dc.contributor.authorLeung, Ren_HK
dc.contributor.authorTsang, KWTen_HK
dc.date.accessioned2010-09-06T05:57:54Z-
dc.date.available2010-09-06T05:57:54Z-
dc.date.issued2000en_HK
dc.identifier.citationEuropean Respiratory Journal, 2000, v. 16 n. 1, p. 146-149en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67748-
dc.description.abstractEndothelin (ET)-1 has been suggested to promote neutrophil adhesion to endothelium, migration to inflamed areas, and release of elastase. ET-1 might therefore play a role in the pathogenesis of bronchiectasis, a chronic inflammatory and infective airway disease which is still poorly understood. Thirty five patients with stable bronchiectasis (20 females, mean age±SD 49.1±15.0 yrs) and 18 control subjects (8 females, 49.4±11.3 yrs) were recruited prospectively. The ET-1 levels in serum and sputum were measured by commercially available enzyme linked immunosorbent assay (ELISA) kits. Patients with Pseudomonas aeruginosa in their sputum had a significantly higher serum level of ET-1 (median 25.8, interquartile range 13-43.9 pg · mL -1) than patients without P. aeruginosa (0, 0-10.5 pg · mL -1; p=0.0004) and healthy control subjects (4.6, 0-16.3 pg · mL -1; p=0.002). However, patients with and without P. aeruginosa infection had no significant difference in sputum ET-1 level (p=0.15). There was no correlation between serum or sputum ET-1 levels with the serum and sputum levels of the interleukin (IL)-1β, IL-8 and tumour necrosis factor (TNF)-α; the number of bronchiectasis lung lobes; and spirometry. Serum ET-1 level correlated with 24 h sputum volume for the bronchiectasis patients (r=0.51, p=0.002). The results, therefore, suggest a significant pathogenic role for endothelin-1 among Pseudomonas aeruginosa-infected patients with bronchiectasis. Further studies should be performed to evaluate the clinico-pathological correlation and expression of endothelin-1 in bronchiectasis. (C)ERS Journals Ltd 2000.en_HK
dc.languageengen_HK
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subjectBronchiectasisen_HK
dc.subjectCytokinesen_HK
dc.subjectEndothelin-1en_HK
dc.subjectSputumen_HK
dc.subject.meshBronchiectasis - complications - metabolism - microbiologyen_HK
dc.subject.meshEndothelin-1 - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterleukin-1 - analysisen_HK
dc.subject.meshInterleukin-8 - analysisen_HK
dc.subject.meshLeukocytesen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPancreatic Elastase - analysisen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshPseudomonas Infections - complications - metabolismen_HK
dc.subject.meshPseudomonas aeruginosa - isolation & purificationen_HK
dc.subject.meshRespiratory Tract Infections - complicationsen_HK
dc.subject.meshSputum - chemistry - cytology - microbiologyen_HK
dc.subject.meshTumor Necrosis Factor-alpha - analysisen_HK
dc.titleEndothelin-1 in stable bronchiectasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0903-1936&volume=16&issue=1&spage=146&epage=149&date=2000&atitle=Endothelin-1+in+stable+bronchiectasisen_HK
dc.identifier.emailTipoe, G:tgeorge@hkucc.hku.hken_HK
dc.identifier.emailHo, JCM:jhocm@hku.hken_HK
dc.identifier.authorityTipoe, G=rp00371en_HK
dc.identifier.authorityHo, JCM=rp00258en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1034/j.1399-3003.2000.16a26.xen_HK
dc.identifier.pmid10933101-
dc.identifier.scopuseid_2-s2.0-0033911955en_HK
dc.identifier.hkuros50906en_HK
dc.identifier.hkuros54582-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033911955&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue1en_HK
dc.identifier.spage146en_HK
dc.identifier.epage149en_HK
dc.identifier.isiWOS:000088262500026-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridZheng, L=7403404086en_HK
dc.identifier.scopusauthoridTipoe, G=7003550610en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridHo, JCM=7402649981en_HK
dc.identifier.scopusauthoridShum, I=6602960338en_HK
dc.identifier.scopusauthoridOoi, GG=7006176114en_HK
dc.identifier.scopusauthoridLeung, R=7101876102en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK

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