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Article: Significance of molecular signaling for protein translation control in neurodegenerative diseases

TitleSignificance of molecular signaling for protein translation control in neurodegenerative diseases
Authors
Issue Date2007
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
Neurosignals, 2007, v. 15 n. 5, p. 249-258 How to Cite?
AbstractIt has long been known that protein synthesis is inhibited in neurological disorders. Protein synthesis includes protein transcription and translation. While many studies about protein transcription have been done in the last decade, we are just starting to understand more about the impact of protein translation. Protein translation control can be accomplished at the initiation or elongation steps. In this review, we will focus on translation control at initiation. Neurons have long neurites in which proteins have to be transported from the cell body to the end of the neurite. Since supply of proteins cannot meet the need of neuronal activity at the spine, protein locally translated at the spine will be a good solution to replace the turnover of proteins. Therefore, local protein translation is an important mechanism to maintain normal neuronal functions. In this notion, we have to separate the concept of global and local protein translation control. Both global and local protein translation control modulate normal neuronal functions from development to cognitive functions. Increasing lines of evidence show that they also play significant roles in neurodegenerative diseases, e.g. neuronal apoptosis, synaptic degeneration and autophagy. We summarize all the evidence in this review and focus on the control at initiation. The new live-cell imaging technology together with photoconvertible fluorescent probes allows us to investigate newly translated proteins in situ. Protein translation control is another line to modulate neuronal function in neuron-neuron communication as well as in response to stress in neurodegenerative diseases. Copyright © 2007 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/67746
ISSN
2015 Impact Factor: 1.593
2015 SCImago Journal Rankings: 0.763
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, RCCen_HK
dc.contributor.authorYu, MSen_HK
dc.contributor.authorLai, CSWen_HK
dc.date.accessioned2010-09-06T05:57:53Z-
dc.date.available2010-09-06T05:57:53Z-
dc.date.issued2007en_HK
dc.identifier.citationNeurosignals, 2007, v. 15 n. 5, p. 249-258en_HK
dc.identifier.issn1424-862Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67746-
dc.description.abstractIt has long been known that protein synthesis is inhibited in neurological disorders. Protein synthesis includes protein transcription and translation. While many studies about protein transcription have been done in the last decade, we are just starting to understand more about the impact of protein translation. Protein translation control can be accomplished at the initiation or elongation steps. In this review, we will focus on translation control at initiation. Neurons have long neurites in which proteins have to be transported from the cell body to the end of the neurite. Since supply of proteins cannot meet the need of neuronal activity at the spine, protein locally translated at the spine will be a good solution to replace the turnover of proteins. Therefore, local protein translation is an important mechanism to maintain normal neuronal functions. In this notion, we have to separate the concept of global and local protein translation control. Both global and local protein translation control modulate normal neuronal functions from development to cognitive functions. Increasing lines of evidence show that they also play significant roles in neurodegenerative diseases, e.g. neuronal apoptosis, synaptic degeneration and autophagy. We summarize all the evidence in this review and focus on the control at initiation. The new live-cell imaging technology together with photoconvertible fluorescent probes allows us to investigate newly translated proteins in situ. Protein translation control is another line to modulate neuronal function in neuron-neuron communication as well as in response to stress in neurodegenerative diseases. Copyright © 2007 S. Karger AG.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofNeuroSignalsen_HK
dc.rightsNeurosignals. Copyright © S Karger AG.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshEukaryotic Initiation Factor-2en_HK
dc.subject.meshHumansen_HK
dc.subject.meshNeurodegenerative Diseases - metabolism - pathology - physiopathologyen_HK
dc.subject.meshNeurons - physiologyen_HK
dc.subject.meshProtein Biosynthesis - physiologyen_HK
dc.subject.meshProtein Transport - physiologyen_HK
dc.subject.meshSignal Transduction - physiologyen_HK
dc.titleSignificance of molecular signaling for protein translation control in neurodegenerative diseasesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1424-862X&volume=15&spage=249&epage=258&date=2007&atitle=Significance+of+molecular+signaling+for+protein+translation+control+in+neurodegenerative+diseasesen_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000102599en_HK
dc.identifier.pmid17496426-
dc.identifier.scopuseid_2-s2.0-34547944390en_HK
dc.identifier.hkuros127013en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547944390&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue5en_HK
dc.identifier.spage249en_HK
dc.identifier.epage258en_HK
dc.identifier.isiWOS:000248237500004-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK
dc.identifier.scopusauthoridYu, MS=35346047600en_HK
dc.identifier.scopusauthoridLai, CSW=26022547000en_HK

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