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Article: Pupillary constriction in response to light in rodents, which does not depend on central neural pathways

TitlePupillary constriction in response to light in rodents, which does not depend on central neural pathways
Authors
Issue Date1992
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jns
Citation
Journal Of The Neurological Sciences, 1992, v. 113 n. 1, p. 70-79 How to Cite?
AbstractWe show here that the widely held belief that reflex constriction of the mammalian pupil in response to light depends exclusively upon neural pathways between eye and brain is in need of revision. We investigated the response of the pupil to light in dark-adapted rodents (golden hamsters; hooded rats; albino rats) subjected to a variety of surgical and pharmacological interventions designed to destroy or block all of the neural pathways and structures through which the reflex could be mediated. The interventions included bilateral intraorbital optic nerve section, or unilateral intracranial optic nerve section with enucleation of the contralateral eye, combined in some cases with bilateral removal of the superior cervical ganglia and/or pinealectomy; topical application of atropine; intraocular injection of tetrodotoxin (TTX). Golden hamsters and hooded rats, but not albino rats, retained an effective constriction of the pupil in response to light after all of these interventions, although the constriction was less and slower than in normal animals. These findings show that hamsters and hooded rats have both a neurally mediated fast light reflex that can be eliminated by severing connections between eye and brain, by blockade of cholinergic transmission to iris smooth muscle, and by blockade of action potentials by TTX; and a local, slower constriction in response to light, which remains after all these procedures. We have also confirmed previous observations of Bito and Turansky (1975) that pupillary constriction in response to light occurs in isolated in vitro anterior chamber preparations of hamster and hooded rat eyes. However, we were not able to demonstrate constriction in identical preparations of albino rat eyes. The data suggest on the basis of both in vivo and in vitro studies, that the hamster and hooded rat, but not the albino rat, possess an autonomous local mechanism for controlling pupillary diameter that is completely independent of the retina or the brain.
Persistent Identifierhttp://hdl.handle.net/10722/67743
ISSN
2015 Impact Factor: 2.126
2015 SCImago Journal Rankings: 1.024
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, KCen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorCampbell, Gen_HK
dc.contributor.authorLieberman, ARen_HK
dc.date.accessioned2010-09-06T05:57:51Z-
dc.date.available2010-09-06T05:57:51Z-
dc.date.issued1992en_HK
dc.identifier.citationJournal Of The Neurological Sciences, 1992, v. 113 n. 1, p. 70-79en_HK
dc.identifier.issn0022-510Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67743-
dc.description.abstractWe show here that the widely held belief that reflex constriction of the mammalian pupil in response to light depends exclusively upon neural pathways between eye and brain is in need of revision. We investigated the response of the pupil to light in dark-adapted rodents (golden hamsters; hooded rats; albino rats) subjected to a variety of surgical and pharmacological interventions designed to destroy or block all of the neural pathways and structures through which the reflex could be mediated. The interventions included bilateral intraorbital optic nerve section, or unilateral intracranial optic nerve section with enucleation of the contralateral eye, combined in some cases with bilateral removal of the superior cervical ganglia and/or pinealectomy; topical application of atropine; intraocular injection of tetrodotoxin (TTX). Golden hamsters and hooded rats, but not albino rats, retained an effective constriction of the pupil in response to light after all of these interventions, although the constriction was less and slower than in normal animals. These findings show that hamsters and hooded rats have both a neurally mediated fast light reflex that can be eliminated by severing connections between eye and brain, by blockade of cholinergic transmission to iris smooth muscle, and by blockade of action potentials by TTX; and a local, slower constriction in response to light, which remains after all these procedures. We have also confirmed previous observations of Bito and Turansky (1975) that pupillary constriction in response to light occurs in isolated in vitro anterior chamber preparations of hamster and hooded rat eyes. However, we were not able to demonstrate constriction in identical preparations of albino rat eyes. The data suggest on the basis of both in vivo and in vitro studies, that the hamster and hooded rat, but not the albino rat, possess an autonomous local mechanism for controlling pupillary diameter that is completely independent of the retina or the brain.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jnsen_HK
dc.relation.ispartofJournal of the Neurological Sciencesen_HK
dc.rightsJournal of the Neurological Sciences. Copyright © Elsevier BV.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCentral Nervous System - physiologyen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshDark Adaptationen_HK
dc.subject.meshDenervationen_HK
dc.subject.meshLighten_HK
dc.subject.meshMesocricetusen_HK
dc.subject.meshNeural Pathways - physiologyen_HK
dc.subject.meshOptic Nerve - physiologyen_HK
dc.subject.meshPigmentationen_HK
dc.subject.meshPineal Gland - physiologyen_HK
dc.subject.meshPupil - radiation effectsen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReaction Timeen_HK
dc.titlePupillary constriction in response to light in rodents, which does not depend on central neural pathwaysen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-510X&volume=113&spage=70&epage=79&date=1992&atitle=Pupillary+constriction+in+response+to+light+in+rodents,+which+does+not+depend+on+central+neural+pathwaysen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0022-510X(92)90267-Oen_HK
dc.identifier.pmid1469457en_HK
dc.identifier.scopuseid_2-s2.0-0026460881en_HK
dc.identifier.hkuros97746en_HK
dc.identifier.volume113en_HK
dc.identifier.issue1en_HK
dc.identifier.spage70en_HK
dc.identifier.epage79en_HK
dc.identifier.isiWOS:A1992JZ56500011-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLau, KC=16407204200en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridCampbell, G=7401889253en_HK
dc.identifier.scopusauthoridLieberman, AR=7202118609en_HK

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