File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Increased adrenomedullin expression in lungs in endotoxaemia

TitleIncreased adrenomedullin expression in lungs in endotoxaemia
Authors
Issue Date2004
PublisherSociety for Endocrinology. The Journal's web site is located at http://joe.endocrinology-journals.org
Citation
Journal Of Endocrinology, 2004, v. 181 n. 2, p. 339-345 How to Cite?
AbstractAdrenomedullin (AM) is a peptide involved in cardiovascular homeostasis and in inflammation. We examined its expression in a rat model of endotoxaemia. Male Sprague-Dawley rats received intraperitoneal injection of 5 or 10 mg/kg lipopolysaccharide (LPS), or saline as control. Rats were killed at 1, 3, 6, 12 and 24 h after injection. LPS at 5 mg/kg, but not saline, increased plasma AM significantly at 3 h. At 10 mg/kg, plasma AM was raised at 3, 6 and 12 h. Immunoreactive AM concentration in lung increased after 5 or 10 mg/kg LPS, but not saline. PreproAM mRNA level in lung was significantly increased at 3 and 6 h. In conclusion, endotoxin stimulates the expression of AM in the lungs and increases its circulatory concentration. AM may be involved in the systemic response to sepsis. © 2004 Society for Endocrinology.
Persistent Identifierhttp://hdl.handle.net/10722/67735
ISSN
2015 Impact Factor: 4.498
2015 SCImago Journal Rankings: 1.910
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorHwang, ISSen_HK
dc.contributor.authorLi, CYYen_HK
dc.contributor.authorO, WSen_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorLeung, RYHen_HK
dc.contributor.authorKumana, CRen_HK
dc.contributor.authorTang, Fen_HK
dc.date.accessioned2010-09-06T05:57:47Z-
dc.date.available2010-09-06T05:57:47Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Endocrinology, 2004, v. 181 n. 2, p. 339-345en_HK
dc.identifier.issn0022-0795en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67735-
dc.description.abstractAdrenomedullin (AM) is a peptide involved in cardiovascular homeostasis and in inflammation. We examined its expression in a rat model of endotoxaemia. Male Sprague-Dawley rats received intraperitoneal injection of 5 or 10 mg/kg lipopolysaccharide (LPS), or saline as control. Rats were killed at 1, 3, 6, 12 and 24 h after injection. LPS at 5 mg/kg, but not saline, increased plasma AM significantly at 3 h. At 10 mg/kg, plasma AM was raised at 3, 6 and 12 h. Immunoreactive AM concentration in lung increased after 5 or 10 mg/kg LPS, but not saline. PreproAM mRNA level in lung was significantly increased at 3 and 6 h. In conclusion, endotoxin stimulates the expression of AM in the lungs and increases its circulatory concentration. AM may be involved in the systemic response to sepsis. © 2004 Society for Endocrinology.en_HK
dc.languageengen_HK
dc.publisherSociety for Endocrinology. The Journal's web site is located at http://joe.endocrinology-journals.orgen_HK
dc.relation.ispartofJournal of Endocrinologyen_HK
dc.rightsJournal of Endocrinology. Copyright © Society for Endocrinology.en_HK
dc.subject.meshAdrenomedullin-
dc.subject.meshAnimals-
dc.subject.meshEndotoxemia - metabolism-
dc.subject.meshLung - chemistry-
dc.subject.meshPeptides - analysis - blood-
dc.titleIncreased adrenomedullin expression in lungs in endotoxaemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0795&volume=181&issue=2&spage=339&epage=345&date=2004&atitle=Increased+adrenomedullin+expression+in+lungs+in+endotoxaemiaen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailO, WS: owaisum@hkucc.hku.hken_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1677/joe.0.1810339en_HK
dc.identifier.pmid15128282-
dc.identifier.scopuseid_2-s2.0-2942597581en_HK
dc.identifier.hkuros86262en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942597581&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume181en_HK
dc.identifier.issue2en_HK
dc.identifier.spage339en_HK
dc.identifier.epage345en_HK
dc.identifier.isiWOS:000221764700013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridHwang, ISS=7201615103en_HK
dc.identifier.scopusauthoridLi, CYY=36068172200en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridLeung, RYH=7101876102en_HK
dc.identifier.scopusauthoridKumana, CR=7005112381en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats