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Article: Expression of BMP-2 and TGF-β1 mRNA during healing of the rabbit mandible

TitleExpression of BMP-2 and TGF-β1 mRNA during healing of the rabbit mandible
Authors
KeywordsBone morphogenetic protein-2
Fracture healing
In situ hybridization
Transforming growth factor-β1
Issue Date1997
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EOS
Citation
European Journal Of Oral Sciences, 1997, v. 105 n. 4, p. 325-330 How to Cite?
AbstractTo identify the cell types which produce BMP and TGF-β during fracture healing and to elucidate the interactions between BMP and TGF-β in regulating cell proliferation and differentiation at various stages, an experimental model of fracture healing in the rabbit mandible was established and the expression of BMP-2 and TGF-β1 mRNA was studied at different healing stages by in situ hybridization. The results showed that undifferentiated mesenchymal cells, differentiating osteoblasts and chondroblasts, had higher levels of BMP-2 mRNA at the stage of intramembranous bone formation and early chondrogenesis, while the level of TGF-β1 mRNA was higher in chondrocytes and active differentiated osteoblasts during chondrogenesis and endochondral ossification, respectively. We conclude that BMP-2 expression was correlated with the differentiation of mesenchymal cells into osteoblasts and chondrocytes. TGF-β1 mRNA expression was closely associated with the active synthetic stage of osteoblasts and chondrocytes. These observations suggest that both BMP and TGF-β are involved in the regulation of fracture healing. BMP may play an important rôle in bone induction and early chondrogenesis, while TGF-β regulates the proliferation and active synthetic ability of chondrocytes and osteoblasts. © Munksgaard, 1997.
Persistent Identifierhttp://hdl.handle.net/10722/67731
ISSN
2015 Impact Factor: 1.607
2015 SCImago Journal Rankings: 0.681
References

 

DC FieldValueLanguage
dc.contributor.authorSi, Xen_HK
dc.contributor.authorJin, Yen_HK
dc.contributor.authorYang, Len_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorWhite, FHen_HK
dc.date.accessioned2010-09-06T05:57:45Z-
dc.date.available2010-09-06T05:57:45Z-
dc.date.issued1997en_HK
dc.identifier.citationEuropean Journal Of Oral Sciences, 1997, v. 105 n. 4, p. 325-330en_HK
dc.identifier.issn0909-8836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67731-
dc.description.abstractTo identify the cell types which produce BMP and TGF-β during fracture healing and to elucidate the interactions between BMP and TGF-β in regulating cell proliferation and differentiation at various stages, an experimental model of fracture healing in the rabbit mandible was established and the expression of BMP-2 and TGF-β1 mRNA was studied at different healing stages by in situ hybridization. The results showed that undifferentiated mesenchymal cells, differentiating osteoblasts and chondroblasts, had higher levels of BMP-2 mRNA at the stage of intramembranous bone formation and early chondrogenesis, while the level of TGF-β1 mRNA was higher in chondrocytes and active differentiated osteoblasts during chondrogenesis and endochondral ossification, respectively. We conclude that BMP-2 expression was correlated with the differentiation of mesenchymal cells into osteoblasts and chondrocytes. TGF-β1 mRNA expression was closely associated with the active synthetic stage of osteoblasts and chondrocytes. These observations suggest that both BMP and TGF-β are involved in the regulation of fracture healing. BMP may play an important rôle in bone induction and early chondrogenesis, while TGF-β regulates the proliferation and active synthetic ability of chondrocytes and osteoblasts. © Munksgaard, 1997.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EOSen_HK
dc.relation.ispartofEuropean Journal of Oral Sciencesen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectBone morphogenetic protein-2en_HK
dc.subjectFracture healingen_HK
dc.subjectIn situ hybridizationen_HK
dc.subjectTransforming growth factor-β1en_HK
dc.subject.meshBone Morphogenetic Proteins - analysis - genetics-
dc.subject.meshCell Division - genetics-
dc.subject.meshMandibular Fractures - genetics - metabolism - pathology-
dc.subject.meshRNA, Messenger - analysis - genetics-
dc.subject.meshTransforming Growth Factor beta - analysis - genetics-
dc.titleExpression of BMP-2 and TGF-β1 mRNA during healing of the rabbit mandibleen_HK
dc.typeArticleen_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-0722.1997.tb00248.x-
dc.identifier.pmid9298364en_HK
dc.identifier.scopuseid_2-s2.0-0031202254en_HK
dc.identifier.hkuros28485en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031202254&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume105en_HK
dc.identifier.issue4en_HK
dc.identifier.spage325en_HK
dc.identifier.epage330en_HK
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridSi, X=7006044848en_HK
dc.identifier.scopusauthoridJin, Y=26643271200en_HK
dc.identifier.scopusauthoridYang, L=7406279703en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridWhite, FH=7202578907en_HK

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